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| 1 | Apoptosis block as a barrier to effective therapy in non small cell lung cancer显示文摘Lung cancer, is the most common cause of cancer death in men and second only to breast cancer in women. Currently, the first line therapy of choice is platinumbased combination chemotherapy. A therapeutic plateau has been reached with the prognosis for patients with advanced non-small cell lung cancer(NSCLC) remaining poor. New biomarkers of prognosis as well as new therapies focusing on molecular targets are emerging helping to identify patients who are likely to benefit from therapy. Despite this, drug resistance remains the major cause for treatment failure. In this article we review the role of apoptosis in mediating drug resistance in NSCLC. Better understanding of this fundamental biological process may provide a rationale for overcoming the current therapeutic plateau. | Ian Paul J Mark Jones | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 2 | Characterisation of Neonicotinoid and Pymetrozine Resistance in Strains of Bemisia tabaci(Hemiptera:Aleyrodidae)from China显示文摘Four strains of the Q biotype and one of the B biotype of the whitefly Bemisia tabaci collected from China were characterised for resistance to four neonicotinoid insecticides and pymetrozine.Q biotype strains showed moderate to strong resistance to imidacloprid,thiamethoxam and acetamiprid,but little or no cross-resistance to dinotefuron.Resistance to neonicotinoids was consistently associated with resistance to pymetrozine,despite the latter having a distinct(though unresolved)mode of action.The single B biotype strain proved largely susceptible to all the insecticides investigated.Resistance in the Q biotype strains was associated with over-expression of a cytochrome P450 monooxygenase gene,CYP6CM1,whose substrate specificity presumably accounts for the observed cross-resistance profiles. | RAO Qiong XU Yong-hua LUO Chen ZHANG Hong-yu Christopher M Jones Greg J Devine KevinGorman Ian Denholm | 2012 | Journal of Integrative Agriculture2012，11，2： | 7 |
| 3 | 成人直肠脱垂、直肠内套叠、直肠前膨出及阴道肠疝的评估与处理显示文摘直肠脱垂是指直肠全层肠壁突出于肛缘。直肠内脱垂或称直肠内套叠的定义为直肠全层肠壁脱垂但并没有突出于肛门外。直肠脱垂和内套叠常常与直肠前膨出(直肠阴道隔向前方疝人阴道)和阴道肠疝(直肠阴道腹膜形成深疝)同时存在。总地来说,这些问题常统称作“盆底功能障碍”。本综述的重点是后盆腔,即直肠,上述疾病均绕其发生。 | Oliver M Jones Christopher Cunningham Ian Lindsey 苏万春(译) 陈雷(校) | 2011 | 英国医学杂志中文版2011，14，3： | 3 |
| 4 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 5 | Increased Matrix Metalloproteinase-9 Activity in Unstable Carotid Plaques: A Potential Role in Acute Plaque Disruption显示文摘 | Ian M. Loftus A. Ross Naylor Stephen Goodall Matthew Crowther Louise Jones Peter R. F. Bell Matthew M. Thompson | 2000 | Stroke: Journal of the American Heart Association2000，，1： | 2 |
| 6 | Botulinum Toxin as Second-Line Therapy for Chronic Anal Fissure Failing 0.2 Percent Glyceryl Trinitrate显示文摘 | Ian Lindsey F.R.A.C.S. Oliver M. Jones F.R.C.S. Chris Cunningham M.D. F.R.C.S. Bruce D. George M.S. F.R.C.S. Neil J. M. Mortensen M.D. F.R.C.S | 2003 | Diseases of the Colon & Rectum2003，，3： | 2 |
| 7 | The study of aluminium anodes for high power density Al/air batteries with brine electrolytes显示文摘 | Maria Nestoridi Derek Pletcher Robert J.K. Wood Shuncai Wang Richard L. Jones Keith R. Stokes Ian Wilcock | 2008 | Journal of Power Sources2008，，1： | 2 |
| 8 | Biodegradable magnesium alloys for orthopaedic applications显示文摘There is increasing interest in the development of bone repair materials for biomedical applications.Magnesium(Mg)-based alloys have a natural ability to biodegrade because they corrode in aqueous media;they are thus promising materials for orthopaedic device applications in that the need for a secondary surgical operation to remove the implant can be eliminated.Notably,Mg has superior biocompatibility because Mg is found in the human body in abundance.Moreover,Mg alloys have a low elastic modulus,close to that of natural bone,which limits stress shielding.However,there are still some challenges for Mg-based fracture fixation.The degradation of Mg alloys in biological fluids can be too rapid,resulting in a loss of mechanical integrity before complete healing of the bone fracture.In order to achieve an appropriate combination of bio-corrosion and mechanical performance,the microstructure needs to be tailored properly by appropriate alloy design,as well as the use of strengthening processes and manufacturing techniques.This review covers the evolution,current strategies and future perspectives of Mg-based orthopaedic implants. | Yu Lu Subodh Deshmukh Ian Jones Yu-Lung Chiu | 2021 | Biomaterials Translational2021，2，3： | 2 |
| 9 | Dynamic Article: Permanent Sacral Nerve Stimulation Under Local Anesthesia: Feasibility, Best Practice, and Patient Satisfaction显示文摘 | Kim J. Gorissen Alexander L. A. Bloemendaal Siriluck Prapasrivorakul Martijn P. Gosselink Oliver M. Jones Chris Cunningham Ian Lindsey Roel Hompes | 2015 | Diseases of the Colon & Rectum2015，，： | 1 |
| 10 | Laser welding for plastics components显示文摘 | Jones Ian | 2002 | Assembly Automation2002，22，2： | 1 |
| 11 | Comer detection and matching for visual tracking during power line inspection显示文摘 | Ian Golightly Dewi Jones | 2003 | Image and Vision Computing2003，21，9： | 1 |
| 12 | Rapid Parallel Expression in E. Coli and Insect Cells: Analysis of Five Lef Gene Products of the Autographa Californica Multiple Nuclear Polyhedrosis Virus (AcMNPV)显示文摘 | Xiaodong Xu Ian M. Jones | 2004 | Virus Genes2004，，2： | 1 |
| 13 | Laser welding for plastic components显示文摘 | Ian Jones | 2002 | Assembly Automation2002，22，2： | 1 |
| 14 | Assessment and management of acute asthma in the elderly: a comparison with younger asthmatics 显示文摘 | Ian S Petheram DA Jones JV Collins | 1982 | Postgraduate Medical1982，58，2： | 1 |
| 15 | Cardiotrophin-1: Expression in experimental myocardial infarction and potential role in post-MI wound healing显示文摘 | Darren H. Freed Michael C. Moon Anna M. Borowiec Stephen C. Jones Peter Zahradka Ian M.C. Dixon | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 16 | Screening for Antitumor Activity of 11 Species of Indonesian Zingiberaceae Using Human MCF-7 and HT-29 Cancer Cells显示文摘 | Chandra Kirana Ian R. Record Graeme H. McIntosh Graham P. Jones | 2003 | Pharmaceutical Biology2003，，： | 1 |
| 17 | Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents显示文摘 | Ben Li Eric Dale Jones Enkun Zhou Li Chen Dean Cameron Baylis Shanghai Yu Miao Wang Xing He Jonathan Alan Victor Coates David Ian Rhodes Gang Pei John Joseph Deadman Xin Xie Dawei Ma | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，17： | 1 |
| 18 | Rendering for an interactive 360° light filed display 显示文摘 | Jones Andrew McDowall Ian Yamada Hideshi | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 19 | The synthesis,characterization and thermal behavior of functionalized aryl cyanate ester monomer显示文摘 | John M Barton Ian Hamerton John R Jones | 1992 | Polym Int1992，29，2： | 1 |
| 20 | Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients显示文摘 | David S. P. Tan Caterina Marchió Robin L. Jones Kay Savage Ian E. Smith Mitch Dowsett Jorge S. Reis-Filho | 2008 | Breast Cancer Research and Treatment2008，，1： | 1 |
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