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| 1 | Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues显示文摘The extracellular matrix(ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2(Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Matn2 can also promote or suppress tumor growth. | éva Korpos Ferenc Deák Ibolya Kiss | 2015 | Neural Regeneration Research2015，10，6： | 2 |
| 2 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 3 | Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?显示文摘Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease. | Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus | 2014 | World Journal of Clinical Cases2014，2，12： | 1 |
| 4 | Bronchial capillary hemangioma in adults显示文摘 | János Strausz Ibolya Soltész | 1999 | Pathology & Oncology Research1999，，3： | 1 |
| 5 | Novel synthetic phytochelation-based capacitive biosensor for heavy metal ion detection显示文摘 | Ibolya Bontidean Josefin Ahlqvist | 2003 | Biosensors and Bioelectronics2003，18，： | 1 |
| 6 | Simultaneous determination of organic acids and sugars in apples by gas-liquid chromatography显示文摘 | Magdolna M Ibolya M | | 0，，： | 1 |
| 7 | Biosensors for detection of mercury in contaminated soils显示文摘 | Ibolya Bontidean Alessia Mortari | 2004 | Environmental Pollution2004，131，： | 1 |
| 8 | Simultaneous determination of organic acids and sugars in apples by gas-liquid chromatography显示文摘 | Magdolna M Ibolya M | | 0，，： | 1 |
| 9 | Highly efficient phosphodiester hydrolysis promoted by a dinuclear copper ( Ⅱ ) complex显示文摘 | Yvonne D Ibolya T | 2001 | Inorg Chem2001，40，： | 1 |
| 10 | Derivatization and chromatographic behavior of the o-phthaldialdehyde amino acid derivatives obtained with various SH-group-containing additives显示文摘 | Ibolya M P | 2001 | J Chromatogr A2001，913，： | 1 |
| 11 | Bacterial metal-resistance proteins and their use in biosensors for the detection of bioavailable heavy metals显示文摘 | Ibolya B Jon R | 2000 | Journal of Inorganic Biochemistry2000，79，： | 1 |
| 12 | 11β-Hydroxyste roid dehydrogenase activity in acromegalic patients with normal or impaired carbohydrate metabolism显示文摘 | Agnes Mondok Ibolya Varga Edit Glaz | 2009 | Steroids2009，74，9： | 1 |
| 13 | Comparison of the stability and UV and fluorescence characteristics of the o-phthaldialdehyde / 3-mercaptopropionic acid and o-phthaldialdehyde / N-acetyl-L-cysteine reagents and those of their amino acid derivatives显示文摘 | IBOLYA MOLNR P IMRE B | 1998 | Journal of Chromatography A1998，798，： | 1 |
| 14 | Derivatization and chromatographic behavior of the ophthaldialdehyde amino acid derivatives obtained with various SH-group-containing additives 显示文摘 | Ibolya MP | 2001 | Chromatogr A2001，913，： | 1 |
| 15 | Advancements in the rapid and sensitive analyses of tryptophan and its metabolites, by chromatography显示文摘 | Ibolya Molnár-Perl | 2007 | International Congress Series2007，，： | 1 |
| 16 | Bacterial metal-resistance proteins and their use in biosensors for the detection of bioavailable heavy metals显示文摘 | Ibolya Bontidean Jon R Jon L | 2000 | Journal of Inorganic Biochemistry2000，，79： | 1 |
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