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| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellura carcinoma显示文摘 | Mihara M Nimura Y Ichimiya S | | 0，，： | 2 |
| 3 | Impingement heat transfer of a single thermal plume on the upper wall显示文摘 | ICHIMIYA K TOSHIHISA Abe | 2003 | International Journal of Heat and Mass Transfer2003，46，18： | 1 |
| 4 | Beneficial effect of tacrolimus on myasthenia gravis with thymoma 显示文摘 | Mitsui T Kunishige M Ichimiya M | 2007 | Neurologist2007，13，2： | 1 |
| 5 | Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland显示文摘 | Suzuki M Ichimiya I Mstsushita F | 1998 | J Laryngol Otol1998，112，10： | 1 |
| 6 | In-vitro effects of antimicrobial agents on Pseudomonas aeruginosa biofilm formation显示文摘 | Ichimiya T Yamasaki T Nasu M | 2009 | Antimicrob Chemother2009，34，3： | 1 |
| 7 | Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction:a retrospective study in patients undergoing primary percutaneous coronary intervention显示文摘 | Ishii H Ichimiya S Kanashiro M | 2006 | Clin Ther2006，28，： | 1 |
| 8 | Identification of a transactivation activity in the COOH -Terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas显示文摘 | Takada N Ozaki T Ichimiya S | | 0，，12： | 1 |
| 9 | Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory显示文摘 | Suhara T Ichimiya T | 2003 | Am J Psychiatry2003，160，： | 1 |
| 10 | Retroperitoneal bronchogenic cyst:a case report显示文摘 | Ingu A Watanabe A Ichimiya Y | 2002 | Chest2002，121，4： | 1 |
| 11 | Localization of glucoeortieoid receptors in the murine inner ear 显示文摘 | Shimazaki T Ichimiya 1 Suzuki M | 2002 | Ann Otol Rhinol Laryngol2002，111，121： | 1 |
| 12 | p73, a gene related to p53,is not mutated in esophageal carcinomas显示文摘 | Nimura Y Mihara M Ichimiya S | 1998 | Int J Cancer1998，78，4： | 1 |
| 13 | Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury显示文摘 | Ichimiya S Davis J G O' Rourke D M | 1997 | DNA Cell Biol1997，16，3： | 1 |
| 14 | Successful treatment of pemphigus vegetans by addition of etretinate to systemic steroids 显示文摘 | Ichimiya M Yamamoto K Muto M | 1998 | Clin Exp Dermatol1998，23，4： | 1 |
| 15 | Significance of spiral ligament fibrocytes with cochlear inflammation显示文摘 | Ichimiya I Yoshida K Hirano T | 2000 | Int J Pediatr Otorhinolaryngol2000，56，1： | 1 |
| 16 | NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain显示文摘 | Ozaki T Nagase T Ichimiya S | 2000 | DNA Cell Biol2000，19，8： | 1 |
| 17 | Impact of the circadian rhythm on microvas - cular function in patients with ST - elevation myocardial infarction 显示文摘 | Suzuki S Ishii H Ichimiya S | 2013 | Int J Cardiol2013，168，5： | 1 |
| 18 | Bcl-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production显示文摘 | AMSTAD P A LIU H ICHIMIYA M | 2001 | Redox Rep2001，6，6： | 1 |
| 19 | Analysis of laminar dissipative flow and heat transfer in porous saturated circular tube with constant wall heat flux显示文摘 | Tada S Ichimiya K | 2007 | International Journal of Heat Mass Transfer2007，50，11： | 1 |
| 20 | Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction: A retrospective study in patients undergoing primary percutaneous coronary intervention显示文摘 | Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro Toru Aoyama Yasuhiro Ogawa Ryuichiro Murakami Tetsuya Amano Keiko Naruse Tatsuaki Matsubara Toyoaki Murohara | 2006 | Clinical Therapeutics2006，，11： | 1 |
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