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| 1 | A comparative laboratory diagnosis of malaria:microscopy versus rapid diagnostic test kits显示文摘Objective:To compare the two methods of rapid diagnostic tests(RDTs)and microscopy in the diagnosis of malaria.Methods:RDTs and microscopy were carried out to diagnose malaria. Percentage malaria parasitaemia was calculated on thin films and all non-acute cases of plasmodiasis with less than 0.001%malaria parasitaemia were regarded as negative.Results were simply presented as percentage positive of the total number of patients under study.The results of RDTs were compared to those of microscopy while those of RDTs based on antigen were compared to those of RDTs based on antibody.Patients' follow-up was made for all cases.Results: All the 200 patients under present study tested positive to RDTs based on malaria antibodies(serum)method(100%).128 out of 200 tested positive to RDTs based on malaria antigen(whole blood)method(64%),while 118 out of 200 patients under present study tested positive to visual microscopy of Lieshman and diluted Giemsa(59%).All patients that tested positive to microscopy also tested positive to RDTs based on antigen.All patients on the second day of follow-up were non-febrile and had antimalaria drugs.Conclusions;We conclude based on the present study that the RDTs based on malaria antigen(whole blood)method is as specific as the traditional microscopy and even appears more sensitive than microscopy.The RDTs based on antibody(serum)method is unspecific thus it should not be encouraged.It is most likely that Africa being an endemic region,formation of certain levels of malaria antibody may not be uncommon.The present study also supports the opinion that a good number of febrile cases is not due to malaria. We support WHO's report on cost effectiveness of RDTs but,recommend that only the antigen based method should possibly,be adopted in Africa and other malaria endemic regions of the world. | Azikiwe CCA Ifezulike CC Siminialayi IM Amazu LU Enye JC Nwakwunite OE | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 2 | Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting显示文摘 | Patrick H. Gibson Bernard L. Croal Brian H. Cuthbertson Gary R. Small Adaeze I. Ifezulike George Gibson Robert R. Jeffrey Keith G. Buchan Hussein El-Shafei Graham S. Hillis | 2007 | American Heart Journal2007，，5： | 1 |
| 3 | HIV/AIDS selective infectivity-report of two peculiar cases显示文摘We report two peculiar cases that were observed in two communities of Anambra State,South East Nigeria.The first case was a woman of 44 with a history of blood transfusion from a donor of questionable HIV status.A pint of blood was transfused in a private Hospital on the 15th January. 2000.She has had no form of antiviral therapy until 22nd April.2008 when she came to the hospital for routine medical check up.Her HIV result came out confirmed positive while that of her husband came out negative.She has had active sexual life with her husband in the previous eight years as they have had some difficulties in getting their desired extra two children having earlier gotten a boy and a girl.The second case involves a family of six.A couple with four children of ages about 6 months,2 years,3 years and 5 years.The youngest,a female presented with fever and multiple lymphadenopathy.She tested HIV positive and so was her mother and her second sibling.But her father and two other siblings remained negative at post three and six months intervals from their very first test date with us.These reported cases appear to go contrary to earher formed opinion on HIV transmission.We support the opinion on a naturally,occurring substance,APOBEC3G which possibly confers permanent immunity against the HIV virus.We recommend clinical trials of the characterized APOBEC3G as a vaccine for non HIV infected persons of all ages and to people living with HIV/AIDS as a therapeutic drug. | Azikiwe CCA Ifezulike CC Amazu LU Enye JC Nwosu PJC Osuala FN | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 0 |
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