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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 3 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 4 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 5 | Kinetic studies on the anaerobic degradation of soluble and particulate matter in potato wastewater 显示文摘 | Ignacio Durruty Noemi E Zaritzky Jorge F Gonzalez | 2012 | Biosystems Engineering2012，，2： | 1 |
| 6 | Electrochemical Characterization of Pyrrhotite Reactivity Under Simulated Weathering Conditions显示文摘 | Roel Cruz Ignacio Gonzalez Marcos Monroy | 2005 | Applied Geo- chemistry2005，20，1： | 1 |
| 7 | Vascular cognitive impairment:prodr-omal stages of ischemic vascular dementia显示文摘 | MORAL A Ignacio MUNOZ A Roberto GONZALEZ M Andres | 2008 | Dement Geriatr Cogn Disord2008，25，5： | 1 |
| 8 | Unusual Presentations of Cerebral Solitary Fibrous Tumors: Report of Four Cases显示文摘 | K. Anthony Kim Ignacio Gonzalez J. Gordon McComb Steven L. Giannotta | 2004 | Neurosurgery2004，，4： | 1 |
| 9 | The Effects of Anesthetic Preconditioning with Sevoflurane in an Experimental Lung Autotransplant Model in Pigs显示文摘 | Javier Casanova Ignacio Garutti Carlos Simon Ana Giraldez Beatriz Martin Guillermo Gonzalez Leire Azcarate Cruz Garcia Elena Vara | 2011 | Anesthesia & Analgesia2011，，4： | 1 |
| 10 | Isolation of K88 antigen variants (ab,ac,ad) from porcine enterotoxigenic Escherichia coli belonging to different serotypes显示文摘 | Gonzalez E A Vazquez F Ignacio Garabal J | 1995 | Microbiol Immunol1995，39，12： | 1 |
| 11 | Vascular cognitive impa-irment:prodromal stages of ischemic vascular dementia显示文摘 | MUNOZ Arrondo Roberto GONZALEZ Mandly Andres | 2008 | Dement Geriatr Cogn Disord2008，25，5： | 1 |
| 12 | Control of the electrochemical reduction of o-nitrophenol by pH imposition in acetonitrile显示文摘 | Alejandro Baeza Jose Luis Ortiz Ignacio Gonzalez | 1997 | Journal of Electroanalytical Chemistry1997，429，12： | 1 |
| 13 | Design, generation and stress analysis of face - gear drivewith helical pinion 显示文摘 | Faydor L Litvina Ignacio Gonzalez - Perezb Alfonso Fuentes | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，2： | 1 |
| 14 | Magnetic nanocomposites based on hydrogenated epoxy resin显示文摘 | Maria Gonzalez Martin-Fabiani Ignacio Baselga Juan? | 2012 | Materials Chemistry and Physics2012，132，23： | 1 |
| 15 | Statistical analysis of the main parameters involved in the design of a genetic algorithm 显示文摘 | Ignacio Rojas Jesus Gonzalez Hector Pomares | 2002 | IEEE Transactions on Systems Man and Cybernetics-Part C: Application and Reviews2002，32，1： | 1 |
| 16 | Resection arthroplasty for radial head fractures: Long-term follow-up显示文摘 | Petrea P. Iftimie Jaume Calmet Garcia Ignacio de Loyola Garcia Forcada Jose Eduardo Gonzalez Pedrouzo Josep Giné Gomà | 2011 | Journal of Shoulder and Elbow Surgery2011，，1： | 1 |
| 17 | Magnetic nanocomposites based on hydrogenated epoxy resin显示文摘 | Maria Gonzalez Martin-Fabiani Ignacio Baselga Juan | 2012 | Materials Chemistry and Physics2012，132，23： | 1 |
| 18 | Isolation of K88 antigen variants (ab,ac,ad)from porcine enterotoxigenic Escherichia coli belonging to different serotypes显示文摘 | Gonzalez EA Vazquez F Ignacio Garabal J | 1995 | Microbiol Immunol1995，39，12： | 1 |
| 19 | Radiomics analysis with three-dimensional and two-dimensional segmentation to predict survival outcomes in pancreatic cancer显示文摘BACKGROUND Radiomics can assess prognostic factors in several types of tumors,but considering its prognostic ability in pancreatic cancer has been lacking.AIM To evaluate the performance of two different radiomics software in assessing survival outcomes in pancreatic cancer patients.METHODS We retrospectively reviewed pretreatment contrast-enhanced dual-energy computed tomography images from 48 patients with biopsy-confirmed pancreatic ductal adenocarcinoma who later underwent neoadjuvant chemoradiation and surgery.Tumors were segmented using TexRad software for 2-dimensional(2D)analysis and MIM software for 3D analysis,followed by radiomic feature extraction.Cox proportional hazard modeling correlated texture features with overall survival(OS)and progression-free survival(PFS).Cox regression was used to detect differences in OS related to pretreatment tumor size and residual tumor following treatment.The Wilcoxon test was used to show the relationship between tumor volume and the percent of residual tumor.Kaplan-Meier analysis was used to compare survival in patients with different tumor densities in Hounsfield units for both 2D and 3D analysis.RESULTS 3D analysis showed that higher mean tumor density[hazard ratio(HR)=0.971,P=0.041)]and higher median tumor density(HR=0.970,P=0.037)correlated with better OS.2D analysis showed that higher mean tumor density(HR=0.963,P=0.014)and higher mean positive pixels(HR=0.962,P=0.014)correlated with better OS;higher skewness(HR=3.067,P=0.008)and higher kurtosis(HR=1.176,P=0.029)correlated with worse OS.Higher entropy correlated with better PFS(HR=0.056,P=0.036).Models determined that patients with increased tumor size greater than 1.35 cm were likely to have a higher percentage of residual tumors of over 10%.CONCLUSION Several radiomics features can be used as prognostic tools for pancreatic cancer.However,results vary between 2D and 3D analyses.Mean tumor density was the only variable that could reliably predict OS,irrespective of the analysis used. | Mohammed Saleh Mayur Virarkar Hagar S Mahmoud Vincenzo K Wong Carlos Ignacio Gonzalez Baerga Miti Parikh Sherif B Elsherif Priya R Bhosale | 2023 | World Journal of Radiology2023，15，11： | 0 |
| 20 | Office Furniture Design for Wheelchair User显示文摘 | Francisca Jose Castillo Rueda Oscar David de Cozar Macias Maria del Carmen Ladron de Guevara Munoz Jose Ignacio Jimenez Gonzalez Elidia Beatriz Blazquez Parra | 2012 | Journal of Civil Engineering and Architecture2012，6，11： | 0 |
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