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| 1 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 2 | Simulation approach to decision assessment in enterprise 显示文摘 | Miroljub K Igor B Andrei S | 2000 | Simulation2000，75，4： | 1 |
| 3 | Tracking-error model-based predictive control for mobile robots in real time 显示文摘 | GREGOR K IGOR S | 2007 | Robotics and Autonomous System2007，55，6： | 1 |
| 4 | Real-time visio-haptic interaction with static soft tissue models having geometric and material nonlinearity显示文摘 | Igor Peterlík Mert Sedef Cagatay Basdogan Luděk Matyska | 2009 | Computers & Graphics2009，，1： | 1 |
| 5 | Nitrogen removal in an anaerobic baffled filter reactor with aerobic post-treatment 显示文摘 | Igor B Karol K | 2003 | Bioresource Technology2003，86，： | 1 |
| 6 | Comprehensive decision tree models in bioinformatics显示文摘 | Gregor S Simon K Igor P | 2012 | PLoS One2012，7，3： | 1 |
| 7 | 3 ' -Minor groove binder-DNA probe increase sequence specificity at PCR extension temperatures显示文摘 | IGOR V K IRINA A A ALAN M | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 8 | Low-complexity image denoising based on statistical modeling of wavelet coefcients显示文摘 | MIHCAK M K IGOR K KANNAN R | 1999 | IEEE Signal Processing Letters1999，6，12： | 1 |
| 9 | Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells显示文摘 | KAREL D IGOR P VLADIMIR K | 2006 | Bioorg Med Chem2006，14，3： | 1 |
| 10 | Improving centrifugal pump efficiency by impeller trimming显示文摘 | Mario (S) Hrvoje K Igor S | | 0，，02： | 1 |
| 11 | The point of maximum cell water volume excursion in case of presence of an impermeable solute 显示文摘 | IGOR I K | 2002 | Cryobiology2002，44，： | 1 |
| 12 | Authentication study of volatile flavour compounds composition in Slavonian traditional dry fermented salami 'kulen'显示文摘 | IGOR J DRAGAN K DRAGOS | 2010 | Food Chemistry2010，，119： | 1 |
| 13 | Solving inverse initial - value boundary - value problems via genetic algorithm 显示文摘 | Charles L K Igor Y Keith N | 2000 | Engineering Application of ArtificialIntelligence2000，13，6： | 1 |
| 14 | Inter- conversion between active and inactive TATA-binding protein transcription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 15 | AFM study of membrane proteins,cytochrome P450 2B4,and NADPH -cytochrome P450 reductase and their complex formation显示文摘 | OLGA I K IGOR V Y YURI O I | 1999 | Archives of Biochem and Biophysic1999，371，1： | 1 |
| 16 | Raman microspectroscopic chemical mapping and chemometric classification for the identification of gunshot residue on adhesive tape 显示文摘 | Bueno · Igor J Lednev K | 2014 | Analytical and Bioanalytical Chemistry2014，406，： | 1 |
| 17 | Alcapa(anomalous origin of the left coronary artery from the pulmonary artery)The 20 Year prince charles hosptital experience显示文摘 | Douglas W Jaifar S Igor K | 2007 | HearttLung and Circulation2007，16，5： | 1 |
| 18 | Simple Algorithm for Virus Spreading Con- trol on Complex Networks 显示文摘 | Igor T Ljupco K | 2012 | IEEE Transactions on Circuits and Systems I : Regular Papers2012，59，4： | 1 |
| 19 | Kinetics and mechanism of hydroxylation of maleic acid by hydrogen peroxide part Ⅰ:formal kinectics显示文摘 | John O Oludipe Kolawole K Koiki Igor Yo Litvintsev | 1990 | J Chem Tech Biotechnol1990，47，： | 1 |
| 20 | Epidermal growth factor receptor in oncology显示文摘 | Vivanco HJ Igor S Ingo K | 2010 | Current Opinion in Oncology2010，22，6： | 1 |
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