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| 1 | Dysbiotic infection in the stomach显示文摘Microbiota in human alimentary tract plays important roles for homeostatic maintenance of the body. Compositional difference of gut microbiota is tightly associated with susceptibility of many diseases,including inflammatory diseases,obesity,diabetes mellitus,cancer,and atherosclerosis. 'Dysbiosis' refers to a state of imbalance among the colonies of microorganisms within the body,which brings abnormal increase of specific minor components and decrease in the normally dominant species. Since stomach secrets strong acid for its digestive role,this organ has long been thought a sterile organ. However,the discovery of Helicobacter pylori(H. pylori) has changed the concept. This bacterium has proven to cause gastritis,peptic ulcer,and gastric cancer. However,recent cross-sectional studies revealed that H. pylori carriers had a decreased risk of developing immunological diseases,such as asthma. H. pylori coinfection also suppresses inflammatory bowel diseases. This review describes human gastric microbiota by discussing its mutual interaction and pathogenic enrollment. Gastric 'dysbiosis' may affect host inflammatory response and play important role for gastric pathogenesis. We will topically discuss enrollment of dysbiosis for genesis of gastric cancer as well as for disruption of immunological homeostasis affecting oncogenic resistance. | Hisashi Iizasa Shyunji Ishihara Timmy Richardo Yuichi Kanehiro Hironori Yoshiyama | 2015 | World Journal of Gastroenterology2015，21，40： | 5 |
| 2 | Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis显示文摘Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)infection,and H.pylori is a major causative agent of gastric cancer.Therefore,it has long been argued that H.pylori infection may affect the development of EBVaGC,a subtype of gastric cancer.Atrophic gastrointestinal inflammation,a symptom of H.pylori infection,is observed in the gastric mucosa of EBVaGC.Therefore,it remains unclear whether H.pylori infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether H.pylori and EBV infections act independently on gastric cancer formation.It has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by H.pylori infection.In contrast,several studies have reported that H.pylori infection accelerates tumorigenesis initiated by EBV infection.By reviewing both clinical epidemiological and experimental data,we reorganized the role of H.pylori and EBV infections in gastric cancer formation. | Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun Nishikawa Hironori Yoshiyama | 2022 | World Journal of Gastroenterology2022，28，44： | 3 |
| 3 | Prospective phase Ⅱ study of post-surgical adjuvant chemo-immunotherapy using autol- ogous dendritic cells and activated killer cells from tissue culture of tumor-draining lymph nodes in primary lung cancer patients 显示文摘 | Kimura H Iizasa T Ishikawa A | 2008 | Anticancer Res2008，28，2： | 1 |
| 4 | The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract显示文摘 | Tachibana K Hirota S Iizasa H | | 0，，6685： | 1 |
| 5 | Tissue-differential ex- pression of two distinct genes for phosphoribosylpyrophos- phate synthetaseand existence of the testis-specific transcript 显示文摘 | TAIRA M IIZASA T YAMADA K | 1989 | Biochim Biophys1989，1007，2： | 1 |
| 6 | Prospective phase Ⅱ study of post-surgical adjuvant chemo-immunotherapy using autologous dendritic cells and activated killer cells from tissue culture of tumor-draining lymph nodes in primary lung cancer patients 显示文摘 | KIMMURA H IIZASA T ISHIKAWA A | 2008 | Anticancer Res2008，28，2： | 1 |
| 7 | Elevated levels of circulatina plasma matrix metalloproteinase-9 in non-small cell lung cancer patients显示文摘 | Iizasa T Fujisawa T Suzuki M | 1999 | Clin Cancer Res1999，5，1： | 1 |
| 8 | Serum endostatin correlates with progression and prognosis of non-small cell lung cancer显示文摘 | Suzuki M Iizasa T Ko E | 2002 | Lung Cancer2002，35，1： | 1 |
| 9 | A polymorphism in the 5-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population显示文摘 | Iizasa T Baba M Saitoh Y et a1 | 2005 | Oncol Rep2005，，4： | 1 |
| 10 | Preoperative pulmonary runction as a prognostic factor for stage I nou-small cell lung carci- noma显示文摘 | Iizasa T Suzuki M Yasufuku K | 2004 | Ann Thorac Surg2004，77，6： | 1 |
| 11 | Elevated Levels of Circulating Plasma Matrix Metalloproteinase 9 in Non-Small Cell Lung Cancer Patients显示文摘 | Toshihiko Iizasa Takehiko Fujisawa Makoto Suzuki | 1999 | Clinical Cancer Research1999，5，1： | 1 |
| 12 | The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells显示文摘 | Kijowski J Baj Krzyworzeka M Iizasa H | 2001 | Stem Cells2001，19，5： | 1 |
| 13 | Overexpression of collagen XVIII is associated with poor outcome and elevated levels of circulating serum endostatin in n α-small cell lung cancer显示文摘 | Iizasa T Chang H Suzuki M | 2004 | Clin Cancer Res2004，10，16： | 1 |
| 14 | The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract 显示文摘 | Tachibana K Hirota S Iizasa H | 1998 | Nature1998，393，6685： | 1 |
| 15 | Prediction of prognosis and surgical indications for pulmonary metastasesctomy from colorectal cancer显示文摘 | Iizasa T Suzuki M Yoshida S | | 0，，： | 1 |
| 16 | L-CBM signaling in lymphocyte development and function 显示文摘 | Hara H Iizasa E Nakaya M | 2010 | J Blood Med2010，2010，1： | 1 |
| 17 | Prospective phase Ⅱ study of post-surgical adjuvant chemo-immunotherapy using autologous dendritic cells and activated killer cells from tissue culture of tumor-draining lymph nodes in primary lung cancer patients 显示文摘 | Kimura H Iizasa T Ishikawa A | 2008 | Anticancer Res2008，28，2： | 1 |
| 18 | Serum endostatin correlates with progression and prognosis of non-small cell lung cancer显示文摘 | Suzuki M Iizasa T Ko E | 2002 | Lung Cancer2002，35，1： | 1 |
| 19 | The chemokine receptor CXCR4is essential for vascularization of the gastrointestinal tract 显示文摘 | Tachibana K Hirota S Iizasa H | 1998 | Nature1998，393，6685： | 1 |
| 20 | Down-regulation of SKP2 induces apoptosis in lung-cancer cells 显示文摘 | Yasui K Iizasa T | 2003 | Cancer Sci2003，94，4： | 1 |
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