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| 1 | Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2and inflammatory bowel disease in the Greek population显示文摘AIM: Crohn's disease(CD)and ulcerative colitis(UC)are multifactorial diseases with a significant genetic background.Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp,Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.METHODS: DNA was obtained from 120 patients with CD,85 with UC and 100 healthy individuals. Genotyping was performed by allele specific PCR or by PCR-RFLP analysis.RESULTS: The 299Gly allele frequency of the TLR4 gene and the T allele and TT genotype frequendes of the CD14 promoter were significantly higher in CD patients only compared to healthy individuals (P = 0.026<0.05; P = 0.0048<0.01 and P= 0.047<0.05 respectively). Concerning the NOD2/CARD15mutations the overall presence in CD patients was significantly higher than that in UC patients or in controls.Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients. It should be pointed out that both frequencies significantly increased as compared with the 10% frequency of multiple carriers found in healthy controls. A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD).CONCLUSION: Our results indicate that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. | Maria Gazouli Gerassimos Mantzaris Athanassios Kotsinas Panayotis Zacharatos Efstathios Papalambros Athanassios Archimandritis John Ikonomopoulos Vassilis G Gorgoulis | 2005 | World Journal of Gastroenterology2005，11，5： | 17 |
| 2 | Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients显示文摘AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratubercu- losis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sar dinian patients with CD and controls. METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written con sent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to cal culate odds ratios (OR) for the associations among CD presence of MAP, and 6 loci described above. RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated withboth NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of ge- netic, infectious, and immunologic factors in the etiology of CD is complex. | Leonardo A Sechi Maria Gazouli Lee E Sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 3 | Predictors ofoutcome following bacterial peritonitis in peritoneal dialysis显示文摘 | Krishnan M Thodis E Ikonomopoulos D | 2002 | PeritDial Int2002，22，5： | 1 |
| 4 | Predictors of out- come following bacterial peritonitis in peritoneal dialysis显示文摘 | Krishnan M Thodis E Ikonomopoulos D | 2002 | Petit Dial Int2002，22，5： | 1 |
| 5 | Survival and complications of 225 catheters used in continuous ambulatory peritoneal dialysis:One-center experience in Northern Greece显示文摘 | Balaskas EV Ikonomopoulos D Sioulis A | 1999 | Perit Dial Int:1999，192，： | 1 |
| 6 | Predictors of outcome following bacterial peritonitis in peritoneal dialysis显示文摘 | Krishnan M Thodis E Ikonomopoulos D | 2002 | Peril Dial Int2002，22，5： | 1 |
| 7 | Predictors of outcome following bacterial peritonitis in peritoneal dialysis 显示文摘 | Krishnan M Thodis E Ikonomopoulos D | 2002 | Perit Dial 1nt2002，22，： | 1 |
| 8 | Intergration of Neural Networks With Fuzzy Rea-soning for Measuring Operational Parameters in a Nuclear Reactor显示文摘 | Isoukalas LH Uhrig RE | 1993 | Nucl Technol1993，104，： | 1 |
| 9 | Detection of mycobacterium avium subsp. paratuberculosis in cheeses from small ruminants in Tuscany显示文摘 | Alessia Galiero Filippo Fratini Antonia Mataragka Barbara Turchi Roberta Nuvoloni John Ikonomopoulos Domenico Cerri | 2016 | International Journal of Food Microbiology2016，，： | 1 |
| 10 | Second-generation image coding techniques 显示文摘 | KUNT M IKONOMOPOULOS A KOCHER M | 1985 | Proceedings of the IEEE1985，73，4： | 1 |
| 11 | Multiplex PCR assay for the detection of mycobacterial DNA sequences directly from sputum显示文摘 | Ikonomopoulos J A Gorgoulis V G Zacharatos P V | 1998 | In Vivo1998，12，5： | 1 |
| 12 | Multiplex PCR assay for the detection of mycobacterial DNA sequences directly from sputum 显示文摘 | Ikonomopoulos J A Gorgoulis V G Zacharatos P V | 1998 | In Vivo1998，12，5： | 1 |
| 13 | Second-generation image-coding teehniques显示文摘 | Kunt M Ikonomopoulos A Kocher M | 1985 | Proceedings of the IEEE1985，73，4： | 1 |
| 14 | Sensitive differential detection of genetically related mycobacterial pathogens in archival material 显示文摘 | Ikonomopoulos JA Gorgoulis VG kastrinakis NG | 2000 | Am J Clin Pathol2000，114，6： | 1 |
| 15 | Second generation image coding显示文摘 | Ikonomopoulos A Kocher M | 1985 | Proceeding of IEEE1985，73，4： | 1 |
| 16 | Evaluation of the Microbial Safety of Child Food of Animal Origin in Greece显示文摘 | Emmanouil Liandris Maria Gazouli Styliani Taka Margarita Andreadou Anna Vaiopoulou Nikolaos Tzimotoudis Ioannis Kasampalidis Dionysis Mpaseas George Fyliousis Palmiro Poltrionieri Nigel Cook John Ikonomopoulos | 2014 | Journal of Food Science2014，，3： | 1 |
| 17 | Evolu-tionary multiobjective optimization of kernel-based very-short-term load forecasting显示文摘 | Alamaniotis M Ikonomopoulos A Tsoukalas L H | 2012 | IEEE Transactions on Pow-er Systems2012，27，3： | 1 |
| 18 | Estimation of the spread of pathogenic Mycobacteria in organic broiler farms by the polymerase chain reaction显示文摘 | Ikonomopoulos J Fragkiadaki E Liandris E | | 0，，03： | 1 |
| 19 | Assessment of mycobacterial, propionibacterial, and human herpesvirus 8 DNA in tissues of greek patients with sarcoidosis 显示文摘 | Gazouli M Ikonomopoulos J Trigidou R | 2002 | J Clin Microbiol2002，40，8： | 1 |
| 20 | Cytological and molecular detection of Leishmania infantum in different tissues of clinically normal and sick cats显示文摘 | Manolis K. Chatzis Margarita Andreadou Leonidas Leontides Dimitrios Kasabalis Mathios Mylonakis Alexandros F. Koutinas Timoleon Rallis John Ikonomopoulos Manolis N. Saridomichelakis | 2014 | Veterinary Parasitology2014，，： | 1 |
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