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| 1 | Gastric cancer:Prevention,screening and early diagnosis显示文摘Gastric cancer continues to be an important healthcare problem from a global perspective. Most of the cases in the Western world are diagnosed at late stages when the treatment is largely ineffective. Helicobacter pylori(H. pylori) infection is a well-established carcinogen for gastric cancer. While lifestyle factors are important,the efficacy of interventions in their modification,as in the use of antioxidant supplements,is unconvincing. No organized screening programs can be found outside Asia(Japan and South Korea). Although several screening approaches have been proposed,including indirect atrophy detection by measuring pepsinogen in the circulation,none of them have so far been implemented,and more study data is required to justify any implementation. Mass eradication of H. pylori in high-risk areas tends to be cost-effective,but its adverse effects and resistance remain a concern. Searches for new screening biomarkers,including microRNA and cancer-autoantibody panels,as well as detection of volatile organic compounds in the breath,are in progress. Endoscopy with a proper biopsy follow-up remains the standard for early detection of cancer and related premalignant lesions. At the same time,new advanced high-resolution endoscopic technologies are showing promising results with respect to diagnosing mucosal lesions visually and targeting each biopsy. New histological risk stratifications(classifications),including OLGA and OLGIM,have recently been developed. This review addresses the current means for gastric cancer primary and secondary prevention,the available and emerging methods for screening,and new developments in endoscopic detection of early lesions of the stomach. | Victor Pasechnikov Sergej Chukov Evgeny Fedorov Ilze Kikuste Marcis Leja | 2014 | World Journal of Gastroenterology2014，20，38： | 64 |
| 2 | Emerging blood-based biomarkers for detection of gastric cancer显示文摘Early detection and efficient monitoring of tumor dynamics are prerequisites for reducing disease burden and mortality, and for improving the management of patients with gastric cancer(GC). Blood-based biomarker assays for the detection of early-stage GC could be of great relevance both for population-wide or risk groupbased screening programs, while circulating biomarkers that reflect the genetic make-up and dynamics of the tumor would allow monitoring of treatment efficacy, predict recurrences and assess the genetic heterogeneity of the tumor. Recent research to identify blood-based biomarkers of GC has resulted in the identification of a wide variety of cancer-associated molecules, including various proteins, autoantibodies against tumor associated antigens, cell-free DNA fragments, m RNAs and various non-coding RNAs, circulating tumor cells and cancer-derived extracellular vesicles. Each type of these biomarkers provides different information on the disease status, has different advantages and disadvantages, and distinct clinical usefulness. In the current review, we summarize the recent developments in blood-based GC biomarker discovery, discuss the origin of various types of biomarkers and their clinical usefulness and the technological challenges in the development of biomarker assays for clinical use. | Zane Kalnina Irēna Meistere Ilze Kikuste Ivars Tolmanis Pawel Zayakin Aija Linē | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 3 | Novel Mycelium-Based Biocomposites (MBB) as Building Materials显示文摘Novel mycelium-based biocomposites(MBB)were obtained from local agricultural(hemp shives)and forestry(wood chips)by-products which were bounded together with natural growth of fungal mycelium.As a result,hemp mycocomposites(HMC)and wood mycocomposites(WMC)were manufactured.Mechanical,water absorption and biodegradation properties of MBB were investigated.MBB were characterized also by ash content and elemental composition.The results of MBB were compared with the reference materials such as the commercial MBB material manufactured by Ecovative®Design(EV),hemp magnesium oxychloride concrete(HC)and cemented wood wool panel(CW),manufactured by CEWOOD®.The mechanical properties of HMC and WMC showed that the bending strength difference was about 30%,with a better result for HMC.Compression strength was better for WMC by about 60%compared to that of HMC.The mechanical strength of HMC and HC materials was equal;both materials contained hemp shives but differed by the binding material.Water absorption and volumetric swelling tests showed that HMC and WMC could be considered as potential biosorbents.Ash content and elemental analysis showed that reference materials(CW,HC)contained significant amounts of inorganic compounds that decreased the biodegradation rate,compared to the case of HMC and WMC materials.The biodegradation results of HMC and WMC,after 12 weeks,revealed a mass loss(ML)above 70%,while in the case of EV,HC and CW,it was about 60%,17%and only 6%,respectively.MBB were completely biodegradable. | Zinta Zimele Ilze Irbe Juris Grinins Oskars Bikovens Anrijs Verovkins Diana Bajare | 2020 | Journal of Renewable Materials2020，8，9： | 2 |
| 4 | Reactive sputtering of nanostructured multilayer coatings and their tribological properties 显示文摘 | Henja Jensen Gunnar Sorensen Ilze Mannike | 1999 | Surface and Coatings Technology1999，，： | 1 |
| 5 | Diagnostic utility of immunohistochemical panel in various thyroid pathologies显示文摘 | Arturs Ozolins Zenons Narbuts Ilze Strumfa Guna Volanska Janis Gardovskis | 2010 | Langenbeck’s Archives of Surgery2010，，7： | 1 |
| 6 | Gastritis staging: interobserver agreement by applying OLGA and OLGIM systems显示文摘 | Sergejs Isajevs Inta Liepniece-Karele Dainius Janciauskas Georgijs Moisejevs Viesturs Putnins Konrads Funka Ilze Kikuste Aigars Vanags Ivars Tolmanis Marcis Leja | 2014 | Virchows Archiv2014，，4： | 1 |
| 7 | Polycyclie aromatic hydrocarbons in meat smoked with dif- ferent types of wood 显示文摘 | Ilze Stumpe -Viksna Vadims Bartkevics Agnese Kukare | 2008 | Food Chemistry2008，，110： | 1 |
| 8 | Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients显示文摘 | Elina S Ilze K Edgars L | 2013 | J Diabetes Complica2013，27，3： | 1 |
| 9 | Association of reduced glyoxalase 1activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients显示文摘 | Elina S Ilze K Edgars L | 2013 | J Diabetes Complica2013，27，3： | 1 |
| 10 | Ultraviolet radiation as a non- thermal treatment for the inactivation of microorganisms in fruit juice显示文摘 | Keyser M Ilze AM Frans PC | 2008 | Innov Food Sci Emerg2008，9，： | 1 |
| 11 | Perivascular Mast Ceils Promote Athero genesis and Induce Plaque Destabilization in Apolipoprotein Mice E-Deficient显示文摘 | Ilze Bot Saskia C de Jager A | 2007 | Circulation2007，115，： | 1 |
| 12 | Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipopro- tein E - deficient mice显示文摘 | Ilze B Saskia CA de Jager | 2007 | Circulation2007，115，： | 1 |
| 13 | Impact of urinary incontinence after stroke: results from a prospective population - based stroke register 显示文摘 | Kolominsky-Rabas PL H ilz MJ Neundoerfer B | 2003 | Neurourol Urodyn2003，22，4： | 1 |
| 14 | A theory of task/technology fit and group support systems effectiveness显示文摘 | Zigurs Ilze Buckland Bonnie K | 1998 | MIS Quarterly1998，22，3： | 1 |
| 15 | EFNS guidelines on the diagnosis and management of orthostatic hypotension显示文摘 | Lahrmann H Cortelli P H ilz M | 2006 | Eur J Neural2006，13，9： | 1 |
| 16 | Leadership in virtual teams:Oxymoron or opportunity? 显示文摘 | Ilze Zigurs | 2003 | Organizational Dynamics2003，31，4： | 1 |
| 17 | leadership in virtual team ,oxymoron or opportunity显示文摘 | ILZE zigurs | 2003 | organizational dynamics2003，31，4： | 1 |
| 18 | Polycyclic aromatic hydrocarbons in meat smoked with different types of wood显示文摘 | ILZE S V BARTKEVIES V KUKARE A | 2008 | Food Chem2008，110，3： | 1 |
| 19 | Interruption of the OX40–OX40 Ligand Pathway in LDL Receptor–Deficient Mice Causes Regression of Atherosclerosis显示文摘 | Amanda C. Foks Gijs H. M. van Puijvelde Ilze Bot Mariette N. D. ter Borg Kim L. L. Habets Jason L. Johnson Hideo Yagita Theo J. C. van Berkel Johan Kuiper | 2013 | The Journal of Immunology2013，，9： | 1 |
| 20 | Shiga Toxin Producing Escherichia coli Infection:Temporal and Quantitative Relationships among Colonization,Toxin Production,and Systemic Disease显示文摘 | Nancy A Cornick Ilze | 2000 | The Journal of Infectious Diseases2000，181，： | 1 |
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