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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | A Review of the response of buried pipelines under seismic excitations 显示文摘 | AR IMAN T MULESKI G E | 1981 | Earthquake Engineering and Structural Dynamics1981，9，： | 1 |
| 3 | An approach to sensitivity analysis of computer models, Part 1, Introduction, input variable selection and preliminary variable assessment显示文摘 | Iman R L Helton J C Campbell J E | 1981 | Journal of Quality Technology1981，13，3： | 1 |
| 4 | Reinforcing epoxy polymer composites through covalent integration of functionalized nanotubes 显示文摘 | Zhu J Peng H Q Rodriguez-Macias F Margrave J L Khabashesku V N Iman A M Lozano K Barrera E V | 2004 | Adv Funct Mater2004，14，7： | 1 |
| 5 | Sensitivity analysis for computer model projections of hurricane losses显示文摘 | Iman R L Johnson M E Watson Jr C C | 2005 | Risk Analysis2005，25，5： | 1 |
| 6 | Uncertainty analysis for computer model projections of hurricane losses显示文摘 | Iman R L Johnson M E Watson Jr C C | 2005 | Risk Analysis2005，25，5： | 1 |
| 7 | Statistical aspects of forecasting and planning for hurricanes显示文摘 | Iman R L Johnson M E Watson Jr C C | 2006 | American Statistician2006，60，2： | 1 |
| 8 | Assessment of lead in cosmeticproducts 显示文摘 | Iman A S Sami A E Neptune S | 2009 | Regulatory Toxicology and Pharmacology2009，54，2： | 1 |
| 9 | Foamed articles based on potato starch,corn fibers and poly (vinyl alcohol)显示文摘 | Chiellini E Cinelli P Iman S H | 2006 | Polym Degrad Stab2006，91，： | 1 |
| 10 | Shoot regeneration and agrobacterium-mediated transformation of Fragaria vesca L显示文摘 | Iman E M Jose A M Victoriano V | | 0，，： | 1 |
| 11 | Sensitivity analysis for computer model projections of hurricane losses显示文摘 | Iman R L Johnson M E Charles C | 2005 | Risk Anal- ysis2005，25，5： | 1 |
| 12 | Uncertainty analysis for computer model projections of hurricane losses 显示文摘 | Iman R L Johnson M E Charles C | 2005 | Risk Anal- ysis2005，25，5： | 1 |
| 13 | Utilization of municipal wastewater for cooling in thermoelectric power plants 显示文摘 | IMAN S MICHAEL E W | 2013 | Fuel2013，，11： | 1 |
| 14 | Elimination noise by adaptive wavelet threshold显示文摘 | Iman E Sadegh Z | 2009 | Proceedings of World Academy of Science Engineering and Technology2009，56，： | 1 |
| 15 | Retinal vein thrombosis associated with pegylated-interferon and ribavirin combination therapy for chronic hepatitis C显示文摘一估计世界范围的 3 亿个人在加拿大与一般人口的 0.8%-1.0% 的流行受不了长期的丙肝。证据的一个增加的水池存在为丙肝支持 pegylated- 干扰素(pegIFN ) 和 ribavirin 联合治疗的使用。我们与长期的丙肝(遗传型 2b ) 报导北美的土著的降下的 49 年的老男性。活体检视证实他与左眼疼痛的 2-wk 历史有肝硬化并且减少视敏度。他在 pegIFN-alpha 2a 和 ribavirin 联合治疗的 24 wk 中的 16 个以后得了网膜的静脉血栓。他是着急地指了一位网膜的专家并且与 non-ischemic 诊断了左眼的中央网膜的静脉吸藏。PegIFN 和 ribavirin 联合治疗被中止, HCV RNA 在处理的 16 wk 以后是无法发现的。Hematologic 调查表明病人是有温和地减少的蛋白质 C 活动的第五因子 Leiden 异质接合体。我们的病人有很多个亢奋的可凝结的风险因素,包括将很可能独自仍然保持临床上沉默的第五因子 Leiden 杂合现象,肝硬化,和丙肝。我们推测在 pegIFN 治疗的背景,这些冒因素的风险,这可以联合并且引起网膜的静脉血栓。 | Iman Zandieh Mohamed Adenwalla Cindy Cheong-Lee Patrick E Ma Eric M Yoshida | 2006 | World Journal of Gastroenterology2006，12，30： | 0 |
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