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| 1 | Suitability and limitations of mesenchymal stem cells to elucidate human bone illness显示文摘Functional impairment of mesenchymal stem cells(MSCs),osteoblast progenitor cells,has been proposed to be a pathological mechanism contributing to bone disorders,such as osteoporosis(the most common bone disease)and other rare inherited skeletal dysplasias.Pathological bone loss can be caused not only by an enhanced bone resorption activity but also by hampered osteogenic differentiation of MSCs.The majority of the current treatment options counteract bone loss,and therefore bone fragility by blocking bone resorption.These socalled antiresorptive treatments,in spite of being effective at reducing fracture risk,cannot be administered for extended periods due to security concerns.Therefore,there is a real need to develop osteoanabolic therapies to promote bone formation.Human MSCs emerge as a suitable tool to study the etiology of bone disorders at the cellular level as well as to be used for cell therapy purposes for bone diseases.This review will focus on the most relevant findings using human MSCs as an in vitro cell model to unravel pathological bone mechanisms and the application and outcomes of human MSCs in cell therapy clinical trials for bone disease. | Izaskun Mitxitorena Arantza Infante Blanca Gener Clara I Rodríguez | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 2 | Sea bass( Dicentrarchus labrax) larvae fed different Artemia rations; growth, pancreas enzymatic response and development of digestive function 显示文摘 | Infante J L I Cahu C L | 1996 | Aquaculture1996，139，12： | 1 |
| 3 | Synergistic effect of two oxidative stress-related genes(heme oxygenase-1 and GSK3beta) on the risk of Parkinson's disease显示文摘 | Infante J Garcia-Gorostiaga I Sanchez-Juan P | 2010 | Eur J Neurol2010，17，： | 1 |
| 4 | Inflammationrelated genes and the risk of Parkinson’s disease:a multilocus ap-proach 显示文摘 | Infante J García Gorostiaga I Sánchez Juan P | 2008 | European Journal of Neurology2008，15，4： | 1 |
| 5 | Equilibrium mer- cury isotope fractionation between dissolved Hg(Ⅱ) species and thiol-bound Hg显示文摘 | Wiederhold J G Daniel K Infante I | 2010 | Environmental Science & Technolo- gy2010，44，： | 1 |
| 6 | Sea bass (Dicentrarchus labrax)larvae fed different Artemia rations;growth,pancreas enzymatic response and development of digestive function显示文摘 | Infante J L I Cahu C L | 1996 | Aquaculture1996，139，12： | 1 |
| 7 | Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease显示文摘 | Mateo I Infante J Llorca J | 2006 | Dement Geriatr Cogn Disord2006，21，4： | 1 |
| 8 | Cholesterylester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associat- ed with APOE epsilon4 allele显示文摘 | Rodriguez E Mateo I Infante J | 2006 | J Neurol2006，253，2： | 1 |
| 9 | Abstract a276: Phase l multicenter, open label, dose-escalation study of LEE011, an oral inhibitor of cyclin-dependent kinase 4/6, in patients with advanced solid tumors or lymphomas 显示文摘 | Infante J R Shapiro G I Witteveen P O | 2013 | Mol Cancer Therap2013，12，11： | 1 |
| 10 | Sea bass(Dicentrarchus labrax)larvae fed different Artemia rations;growth,pancreas enzymatic response and development of digestive function 显示文摘 | Infante J L I Cahu C L | 1996 | Aquac1996，139，12： | 1 |
| 11 | Low serum VEGF levels are associated with Alzheimer's disease 显示文摘 | Mateo I Llorca J Infante J | 2007 | Acta Neurol Scand2007，116，： | 1 |
| 12 | Markers of infection, breastfeeding and childhood acute lymphoblastic leukaemia显示文摘 | Infante - Rivard C Fortier I Olson E | 2000 | Br J Cancer2000，83，： | 1 |
| 13 | Low serum VEGF levels are associated with Alzheimer's disease 显示文摘 | Mateo I Llorca J Infante J | 2007 | Acta Neurol Scand2007，116，1： | 1 |
| 14 | Giant ultrafast photon-induced shear strain in ferroelectric BiFeO3显示文摘 | LEJMAN M VAUDEL G INFANTE I C | 2014 | Nature Communications2014，，5： | 1 |
| 15 | Serum heine oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease显示文摘 | Mateo I Infante J Sanchez-Juan P | 2010 | Acta Neurol Scand2010，121，2： | 1 |
| 16 | Sea bass (Dicentrarchus labrax) larvae fed different Artemia rations;growth,pancreas enzymatic response and development of digestive function显示文摘 | Cahu C L | 1996 | Aquaculture1996，139，12： | 1 |
| 17 | Bridging multi- ferroic phase transitions by epitaxial strain in BiFeO3 显示文摘 | Infante I C Lisenkov S Dup B | 2010 | Physical Review Letters2010，105，05： | 1 |
| 18 | Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with ApoE epsilon4 allele显示文摘 | Rodriguez E Mateo I Infante J | 2006 | J Neurol2006，253，2： | 1 |
| 19 | Association be- tween glycogen synthase kinase-3beta genetic poly- morphism and late-onset Alzheimer 's disease显示文摘 | Mateo I Infante J Llorca J | 2006 | Dement Geriatr Cogn Disord2006，21，4： | 1 |
| 20 | Case-control study of vascular endothelial growth factor(VEGF) genetic variability in Alzheimer's disease 显示文摘 | Mateo I Llorca J Infante J | 2006 | Neurosci Lett2006，401，12： | 1 |
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