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| 1 | Trace element modeling of pelite- derived gTanites 显示文摘 | HARRIS N B W INGER S | 1992 | Contributions to Mineralogy and Petrology1992，110，： | 1 |
| 2 | Geochemical constraints on leucogranitemagmatism in the Langtang Valley, Nepal Himalaya显示文摘 | Inger S Harris N | 1993 | Journal ofPetrology1993，34，： | 1 |
| 3 | Flocculation of colloidal silica with hydrolyzed aluminum:an Al solid state NMR investigation显示文摘 | BOTTERO J Y D REN INGER L S | 1997 | Langmuir1997，13，： | 1 |
| 4 | Source partitioning using stable isotopes: coping with too muchvariation 显示文摘 | Parnell A C Inger R Bearhop S | 2010 | PLoS ONE2010，5，3： | 1 |
| 5 | A pilot study of sail and water restriction in patients with chronic heart failure 显示文摘 | Henriette P Inger E Karl S | 2010 | Scand Cardiov J2010，44，4： | 1 |
| 6 | Carbon and nitrogen in forest floor and mineral soil under six common European tree species 显示文摘 | Lars V Inger K S Ingeborg C | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 7 | Source partitioning using stable isotopes: coping with too much variation显示文摘 | Parnell A C Inger R Bearhop S | 2010 | PLoS One2010，5，3： | 1 |
| 8 | Are B lymphocytes of importance in severe Staphylococcus aureus infections? 显示文摘 | INGER G OLOF H MARTIN S | 2000 | Infection and Immunity2000，68，5： | 1 |
| 9 | Stress and birefringence measurements during the uniaxial elongation of polystyrene melts 显示文摘 | VENERUS D C ZHU S H OTI'INGER H C | 1999 | J Rheol1999，43，： | 1 |
| 10 | Source Partitioning Using Stable Isotopes: Coping with Too Much Variation显示文摘 | Parnell A C Inger R Bearhop S Jackson AL | 2010 | PLoS ONE2010，5，3： | 1 |
| 11 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 12 | Effect of feeding different levels of foliage of Moringa oleifera to creole dairy cows on intake,digestibility, milk production and composition显示文摘 | NADIR R S EVA S INGER L | 2006 | Livestock Science2006，10，1： | 1 |
| 13 | Specific T-Cell Epitopes for Immunoassay-Based Diagnosis of Mycobacterium tuberculosis Infection显示文摘 | Inger Brock Karin Weldingh Eliane M S Leyten | 2004 | Journal of Clinical Microbiology2004，42，： | 1 |
| 14 | A human colon cancer cel capable of initiating tumour growth in immunodeficient mice显示文摘 | O'Brien CA Pol ett A Gal inger S Dick JE | | 0，，7123： | 1 |
| 15 | Multidiseiplinary management of lung cancer显示文摘 | SPIRA A ETI'INGER D S | 2004 | N Engl J Med2004，350，4： | 1 |
| 16 | Trace element modelling of pelite-derived granites显示文摘 | Harris N Inger S | 1992 | Contributions to Mineralogy and Petrology1992，110，： | 1 |
| 17 | Geochemical constraints on leucogranite magmatism in the Langtang Valley, Nepal Himalaya 显示文摘 | Inger S Harris N | 1993 | Journal of Petrology1993，34，： | 1 |
| 18 | Effects of workplace incivility and empowerment on newly-graduated nur- ses organizational commitment显示文摘 | Smith L M Andrusyszyn M A and Lasch- inger H K S | 2010 | Journal of Nursing Management2010，，18： | 1 |
| 19 | Source parti- tioning using stable isotopes:Coping with too much variation 显示文摘 | PARNELL A C INGER R BEARHOP S | 2010 | PLOS ONE2010，5，3： | 1 |
| 20 | Urban tree effects on soil organic carbon 显示文摘 | Edmondson J L O' sullivan 0 S Inger R | 2014 | PLoS One2014，9，10： | 1 |
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