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| 1 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 2 | Erlotinib in previously treated non-small cell lung cancer显示文摘 | Shepherd FA Rodrigues Pereira J Ciuleanu T Tan EH Hirsh V Thongprasert S Campos D Maoleekoonpiroj S Smylie M Martins R van Kooten M Dediu M Findlay B Tu D Johnston D Bezjak A Clark G Santabárbara P Seymour L National Cancer Institute of Canada Clinical T | | 0，，02： | 1 |
| 3 | Building Customer-based Brand Equity: A Blueprint for Creating Strong Brands 显示文摘 | Keller K L Institute M S | 2001 | Marketing Sci- ence Institute2001，10，2： | 1 |
| 4 | Fishery, population dynamics and stock structure of frigate tuna Auxis thazard (Lacepede, 1800)exploited from Indian waters显示文摘 | Intentional Center for Living Kuwait Institute for Scientific GHOSH S SIVADAS M ABDUSSAMAD E M | 2012 | Indian Journal of Fisheries2012，59，2： | 1 |
| 5 | MEASUREMENT OF THE THERMAL PARAMETER OF THEBULK AMORPHOUS Zr_(41)Ti_(14)Ni_(10)Cu_(125)Be_(225)ALLOY显示文摘Thethermal parameterofthe bulk amorphous Zr41 Ti14 Ni10 Cu12 5 Be22 5 alloy thermal dif fusivity,thermalcapacity andcoefficientofthermalconductivityatthestateofsolid andsu percooled liquid hasbeen measuredinthisstudy.It wasfoundthatthecoefficientofthermalconductivity and thethermalcapacity vary significantly with temperature. An error occursinthe measurementofthecoefficientofthethermalconductivity andthethermalcapacity us ing the method adoptedin this paper bothintheglasstransition processand when crystalliza tion processappears. | X L Tian1) ,Y M Sun1) ,S X Zhao1)and X C Chen2) 1) College of Materials Science and Engineering,Shandong University of Technology ,Jinan 250061 ,China2) Institute of Physics,The Chinese Academy of Sciences,Beijing 100081 ,China | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，4： | 0 |
| 6 | 产黄青霉几丁质合成酶基因的克隆及系统学分析(英文) | Namgung J Park B C Park Y D 1 Lee M S 1 Lee D H 2 Bae K S 1 Park H M (Department of Microbiology, Chungnam National University, Taejon 305 764 1 Genetic Resources Center, Korea Research Institute for Bioscience & Biotechnology, Taej | 1999 | 安徽农业大学学报1999，26，3： | 0 |
| 7 | Study of BMPR IA downstream genes related to ventricular septum defect显示文摘Cardiac-specific deletion of the receptor IA of bone morphogenetic protein, ALK3, by Cre recombinase driven under the a-MHC promoter is lethal in mid-gestation with defects in the interventricular septum. Analysis of expression of the ALK3 downstream genes is important to identify the signaling pathway for interventricular septum development. The model mice with ALK3 gene knockout via a-MHC-Cre/lox P system were bred. The mRNA expression level of control group was compared with that of test group. ALK3 downstream genes were screened using PCR-select cDNA subtraction and microarray. It was found that the mice with ALK3 gene knockout produced heart defects involving the interventricular septum. The expression of some genes such as platelet-activating factor acetylhydrolase and the transcription factor Pax-8 etc was downregulated in the test group. The box protein Pax-8 gene expression was downregulated by 7.1 times in the test group and expressed specifically in the embryonic heart (11.5 days). Furthermore, the expression of the Protein Tyrosine Kinase of Focal Adhesion Kinase subfamily (PTK) and beta subtype protein 14-3-3 was upregulated in the a-MHC-Cre+/-ALK3 F/-mice. PTK gene expression was up-regulated by 3.7 times in the test group. These data provided support that ALK3 gene played an important role during heart development. The platelet-activating factor acetylhydrolase and Pax-8 genes could be important ALK3 downstream genes in the BMP signaling pathway during interventncular septum development. PTK and beta subtype protein 14-3-3 might be regulatory factors in this pathway. | YANG DY, ZHANG JY, CHEN CX, XIE M, SPERLING S, FANG F, CHEN BX, LI XW, ZHANG HQ. Department of Cardiology, The First Affiliated Hospital, Institute for Cardiovascular Biology & Gene, Wenzhou Medical College, Wenzhou 325000, P. R.China Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030 Cardiovascular Genetics, Department Prof. H. Lehrach, Max-Planck-Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany | 2007 | 上海医学2007，30，S1： | 0 |
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