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| 1 | Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling显示文摘Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses. | Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2022 | Molecular Plant2022，15，4： | 2 |
| 2 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 3 | CD45: New jobs for an old acquaintance 显示文摘 | Penninger JM Irie Sasaki J Sasaki T | 2001 | Nat Immunol2001，2，5： | 1 |
| 4 | Automated assessment of ovarian follicles using a novel three-dimensional ultrasound software显示文摘 | Todd DD Iris J David OM et a1 | 2009 | Fertility and Sterility2009，92，5： | 1 |
| 5 | Electron emissions from CVD diamond surfaces显示文摘 | Ito T Watanabe T Irie M Nakamura J Teraji T | 2003 | Diamond and Related Materials2003，，12： | 1 |
| 6 | High Proportion of Leukemic Stem Cells at Diagnosis Is Correlated with Unfavorable Prognosis in Childhood Acute Myeloid Leukemia显示文摘 | Kai-Erik Witte J?rg Ahlers Iris Sch?fer Maya André Gunter Kerst Hans-Gerhard Scheel-Walter Carl Philipp Schwarze Matthias Pfeiffer Peter Lang Rupert Handgretinger Martin Ebinger | 2011 | Pediatric Hematology-Oncology2011，，2： | 1 |
| 7 | An Improved Algorithm For Diagnosis Of System Failures In The Chemical Process 显示文摘 | J SHIOZAKI H MATSUYAMA E O'SHIMA M IRI | 1985 | Computers & Chemical Engineering1985，9，： | 1 |
| 8 | Substituted cyclic iraides as potential antigout agents 显示文摘 | Iris H Hall John P Scoville David J | 1990 | Life Sciences1990，46，26： | 1 |
| 9 | Gene expression profiling of mouse condylar cartilage during mastication by means of laser microdissection and cDNA array显示文摘 | Watahiki J Yamaguchi T Irie T | | 0，，03： | 1 |
| 10 | Radical surgery following neoadjuvant chemotherapy for patients with stage Ⅲb cervical cancer显示文摘 | Minagawa Y Kigawa J Irie T | 1998 | Ann Surg Oncol1998，5，6： | 1 |
| 11 | Radiealangery following neoadjuvant chemotherapy for patients with stage 111B cervical cancer 显示文摘 | Minagawa Y Kigswa J Irie T | 1998 | Ann Surg Oncol1998，5，： | 1 |
| 12 | Substituted cyclic imides as potential anti-gout agents显示文摘 | Iris H H John P S David J R | 1990 | Life Sci1990，46，26： | 1 |
| 13 | Risk management processes in supplier networks显示文摘 | Hallikasa J Iris K Urho P | 2004 | International Journal of Production Economics2004，90，2： | 1 |
| 14 | Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity显示文摘 | Irie Y Li D J | 2005 | Bioorg Med Chem2005，13，15： | 1 |
| 15 | Both metabolic inhibition and mitochondrial KATP channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current 显示文摘 | Irie H Gao J Gaudette G R | 2003 | Circulation2003，，： | 1 |
| 16 | Electrical demulsification of w/o emulsion by continuous tubular coalescer显示文摘 | Goto M Irie J Kondo K | 1989 | Journal of Chemical Engineering of Japan1989，22，4： | 1 |
| 17 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 18 | Radical surgery following neoadjuvant chemotherapy for patients with stage ⅢB cervical cancer显示文摘 | Minagawa Y Kigawa J Irie T | 1998 | Ann Surg Oncol1998，5，6： | 1 |
| 19 | Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carci- nogenesis in genetically engineered mice显示文摘 | Iris L Ilyssa O Sujatha J | 2009 | Cancer Prey Res2009，2，9： | 1 |
| 20 | Asymmetric synthesis of trans-2,5-diphenylpyrrolidine: a C2-symmetric chiral a- mine 显示文摘 | J Michael C Ian S C Iris | 1995 | Tetrahedron: Asymmetry1995，6，2： | 1 |
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