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| 1 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 2 | Functional findings in irritable bowel syndrome显示文摘IBS 的病理生理学复杂、仍然不完全地知道。中央、外部的因素,包括的精神分析聚会因素,反常官方补给的活动性和分泌物,和内脏的超敏性,被认为贡献 IBS 的症状。几研究在 IBS 病人表明了改变的官方补给的运动机能,模式基于占优势的肠模式在 IBS 亚群之间不同。很少研究到目前为止在 IBS 探讨了官方补给的分泌物,但是有一些证据,在 IBS 病人的小肠支持改变的分泌物。内脏的超敏性当前被认为也许是在 IBS 的最重要的 pathophysiological 因素。重要地,几个外部、内部的因素能调制内脏的敏感,以及官方补给的活动性,并且在官方补给的道以内提高应答的海角到例如,应力和营养素在 IBS 病人被表明了。今天 IBS 被看在之上,包含在伤寒的反常功能是所谓的大脑勇气轴的 dysregulation 的混乱,自治或中枢神经系统,与可能在一些病人并且在其它的从圆周的信号的扰乱的中央处理统治的外部改变。 | Iris Posserud Amanda Ersryd Magnus Simrén | 2006 | World Journal of Gastroenterology2006，12，18： | 9 |
| 3 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 4 | A novel motion tracking system for evaluation of functional rehabilitation of the upper limbs显示文摘Upper limb function impairment is one of the most common sequelae of central nervous system injury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effectiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensor-based monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We developed a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensor-based motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual reality-based neurorehabilitation system. | ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons | 2013 | Neural Regeneration Research2013，8，19： | 3 |
| 5 | Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications显示文摘Phosphorus(P)is an essential nutrient for plant growth and reproduction.Plants preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient practice.To cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced stress.Intensive research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in plants.Here we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis machinery.We also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient homeostasis.Finally,we discuss advances toward improving PUE and future research priorities. | Javier Paz-Ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva | 2022 | Molecular Plant2022，15，1： | 2 |
| 6 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 7 | Specific binding of glycyrrhetinic acid to the rat liver membrane显示文摘 | Negishi M Irie A Nagata N | 1991 | Biochim Biophys Acta1991，1066，1： | 1 |
| 8 | Osteoclast-osteoblast communication显示文摘 | Matsuo K Irie N | 2008 | Arch Biochem Biophys2008，473，2： | 1 |
| 9 | Bidirectional signaling through ephrinA2 EphA2 enhances osteoclastogenesis and sup- presses osteoblastogenesis显示文摘 | Irie N Takada Y Watanabe Y | 2009 | J Biol Chem2009，284，14： | 1 |
| 10 | Rational Design of Mn-salen Epoxidation Catalysts:Preliminary Results显示文摘 | Hosoya N Hatayama A Irie R | 1994 | Tetrahedron1994，50，15： | 1 |
| 11 | 7-O-Methylated anthocyanidin glycosides from Catharanthus roseus显示文摘 | TOKI K SAITO N IRIE Y | 2008 | Phytochemistry2008，69，5： | 1 |
| 12 | Osteoelast-osteoblast communication显示文摘 | Matsuo K Irie N | 2008 | Arch Biochem Biophys2008，473，2： | 1 |
| 13 | Bidirectional signaling through ephrinA2- EphA2 enhances osteoelastogenesis and suppresses osteoblastogenesis 显示文摘 | Irie N Takada Y Watanabe Y | 2009 | Journal of Biological Chemistry2009，284，21： | 1 |
| 14 | Subtype- and species-specific knockdown of PKC using short interfering RNA显示文摘 | Irie N Sakai N Ueyama T | 2002 | Biochem Biophys Res Commun2002，298，5： | 1 |
| 15 | Severe osteo-porosis in mice lacking osteoclastogenesis inhibitoryfactor/osteoprotegerin 显示文摘 | Mizuno A Amizuka N Irie K | 1998 | Biochem Biophys ResCommun1998，247，3： | 1 |
| 16 | Bidirectional ephrinB2- EphB4 signaling controls bone homeostasis显示文摘 | Zhao C Irie N Takada Y | 2006 | Cell metabo- lism2006，4，2： | 1 |
| 17 | Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypesin Chilean individuals显示文摘 | Karina Cordero Iris Espinoza Dante Caceres Angela Roco Carla Miranda Valentina Squicciarini Paula Santander Kuen Lee Iván Saavedra Luis Qui?ones | 2010 | Oncology Letters2010，，3： | 1 |
| 18 | The use of mild hypothermia for patientswith severe vasospasm: a preliminary report显示文摘 | Irie K Kawai N | 2003 | J Clin Neurosci2003，10，2： | 1 |
| 19 | Osteoclast-osteoblast communication显示文摘 | Matsuo K Irie N | 2008 | ArchBiochem Biophys2008，473，： | 1 |
| 20 | Formation of pyrazine derivatives from D - glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity 显示文摘 | Sutomo K Irie M Mibu N | 1991 | Chem Pharm Bull1991，39，3： | 1 |
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