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| 1 | Current status and challenges in sentinel node navigation surgery for early gastric cancer显示文摘As an optimal surgical procedure to accurately evaluate lymph node(LN)metastasis during surgery with minimal surgical resection,we have been developing sentinel node(SN)biopsy for early gastric cancer since the 1990s.Twelve institutions from the Japanese Society of Sentinel Node Navigation Surgery(SNNS),including Keio University Hospital,conducted a multicenter prospective trial to validate the SN concept using the dual-tracer method with blue dye and a radioisotope.According to the results,397 patients were included in the final analysis,and the overall accuracy in detecting LN metastasis using SN biopsy was 99%(383 of 387).Based on the validation study,we are targeting cT1N0 with a primary tumor of≤4 cm in diameter as an indication for SN biopsy for gastric cancer.We are currently running a multicenter nonrandomized phaseⅢtrial to assess the safety and efficacy of SN navigation surgery.The Korean group has reported the result of a multicenter randomized phaseⅢtrial.Since meticulous gastric cancer in the remnant stomach was rescued by subsequent gastrectomy,the disease-specific survival was comparable between the two techniques,implying that SN navigation surgery can be an alternative to standard gastrectomy.With the development of SN biopsy procedure and treatment modalities,the application of SN biopsy will be expanded to achieve an individualized minimally invasive surgery. | Satoru Matsuda Tomoyuki Irino Hirofumi Kawakubo Hiroya Takeuchi Yuko Kitagawa | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 2 | Laparoscopic-endoscopic cooperative surgery for duodenal tumors: a unique procedure that helps ensure the safety of endoscopic submucosal dissection显示文摘 | Tomoyuki Irino Souya Nunobe Naoki Hiki Yorimasa Yamamoto Toshiaki Hirasawa Manabu Ohashi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2014 | Endoscopy2014，，： | 2 |
| 3 | Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden显示文摘Objective: Curative gastric cancer surgery entails removal of the primary tumor with adequate margins including regional lymph nodes. European randomized controlled trials with recruitment in the 1990's reported increased morbidity and mortality for D2 compared to D1. Here, we examined the extent of lymphadenectomy during gastric cancer surgery and the associated risk for postoperative complications and mortality using the strengths of a population-based study.Methods: A prospective nationwide study conducted within the National Register of Esophageal and Gastric Cancer. All patients in Sweden from 2006 to 2013 who underwent gastric cancer resections with curative intent were included. Patients were categorized into D0, D1, or D1+/D2, and analyzed regarding postoperative morbidity and mortality using multivariable logistic regression.Results: In total, 349(31.7%) patients had a D0, 494(44.9%) D1, and 258(23.4%) D1+/D2 lymphadenectomy.The 30-d postoperative complication rates were 25.5%, 25.1% and 32.2%(D0, D1 and D1+/D2, respectively), and 90-d mortality rates were 8.3%, 4.3% and 5.8%. After adjustment for confounders, in multivariable analysis, there were no significant differences in risk for postoperative complications between the lymphadenectomy groups. For90-d mortality, there was a lower risk for D1 vs. D0.Conclusions: The majority of gastric cancer resections in Sweden have included only a limited lymphadenectomy(D0 and D1). More extensive lymphadenectomy(D1+/D2) seemed to have no impact on postoperative morbidity or mortality. | chih-han kung huan song weimin ye magnus nilsson jan johansson ioannis rouvelas tomoyuki irino lars lundell jon a tsai mats lindblad | 2017 | Chinese Journal of Cancer Research2017，29，4： | 2 |
| 4 | Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity显示文摘 | Yuki Kawakami Tomoko Hosokawa Tomoko Morinaka Shioka Irino Shiori Hirano Hirokazu Kobayashi Akiko Yoshioka Toshiko Suzuki-Yamamoto Miyuki Yokoro Masumi Kimoto Hideaki Tsuji Hiromi Yamashita Shinobu Doi Chikao Yutani Rina Kato Hiroyuki Itabe Teruyuki Kanad | 2011 | Food Chemistry2011，，4： | 1 |
| 5 | Akt activation is involved in P2Y12 receptor-mediated chemotaxis of mieroglia 显示文摘 | Irino Y Nakamura Y Inoue K | 2008 | J Neurosci Res2008，86，： | 1 |
| 6 | Efficacy and safety of biweekly nedaplatin in combination with docetaxel as second-line chemotherapy in patients with unresectable or recurrent esophageal cancer 显示文摘 | Irino T Egawa T Kenmochi T | 2011 | Gan To Kagaku Ryoho2011，38，12： | 1 |
| 7 | The impact of surgical outcome after pancreaticoduodenectomy in elderly patients显示文摘 | Ito Y Kenmochi T Irino T | 2012 | Hepatogastroenterology2012，59，120： | 1 |
| 8 | Pharmacologically active compounds in the A noectochilus and Goodyera species 显示文摘 | DU XIAO MING NOBUTO IRINO NORIHtRO FURUSHO | 2008 | Journal of Natural Medicines2008，62，2： | 1 |
| 9 | High-resolution reconstruction of variation in aeolian dust (Kosa) deposition at ODP site 797, the Japan Sea, during the last 200 ka 显示文摘 | Irino T Tada R | 2002 | Global and Planetary Change2002，35，： | 1 |
| 10 | Comparison of two liquid preservatives for Surepath- slides prepared from voidedurine显示文摘 | Ohsaki H Shigematsu Y Irino S | 2013 | Diagn Cytopathol2013，，： | 1 |
| 11 | Inhibitory effect of sodUm salicylate on APP-induced platelet aggregationadn on 45 Ca2 + uptake into platecets显示文摘 | Irino O Saitoh K Ohkubo K | 1985 | Thromb Res1985，39，3： | 1 |
| 12 | Robust and accurate fundamental frequency estimation based on dominant harmonic components 显示文摘 | Nakatani T Irino T | 2004 | J Acoust Soc Am2004，116，6： | 1 |
| 13 | Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)显示文摘 | Takeshita S Hosokawa M Irino M | 1982 | Mech Ageing Dev1982，20，1： | 1 |
| 14 | A time-domain, level-dependent auditory filter: The gammachirp 显示文摘 | Irino T Patterson R D | 1997 | The Journal of the Acoustical Society of America1997，101，1： | 1 |
| 15 | Involvement of P2X4 and P2YI2 receptors in ATP-induced microglial ehemotaxis显示文摘 | Ohsawa K Irino Y Nakamura Y | 2007 | Gila2007，55，： | 1 |
| 16 | Virulence profile comparison between LEE-negative Shiga toxin-producing Escherichia coli (STEC) strains isolated from cattle and humans显示文摘 | GALLI L MILIWEBSKY E IRINO K | 2010 | Veterinary Microbiology2010，143，： | 1 |
| 17 | Characterisation of diarrhoeagenic Escherichia coli clones by ribotyping and ERIC-PCR显示文摘 | DALLA-COSTA L M IRINO K RODRIGUES J | 1998 | Journal of Medical Microbiol1998，47，3： | 1 |
| 18 | Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer显示文摘BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical aspects.Several studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal surgery.However,no study has shown the association between postoperative complications and long-term survival of patients with EGJ cancer.AIM To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ cancer.METHODS A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this study.We examined the association between complications and long-term oncologic outcomes.RESULTS In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic leakage.However,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic anastomosis.Cervical anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage. | Masashi Takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya Takeuchi Yuko Kitagawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 19 | Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdeha4 显示文摘 | Irino Y Cho H Nakamura Y | 2004 | Biochem Biophys Res Commun2004，320，2： | 1 |
| 20 | Quantification of aeolian dust (Kosa) contribu- tion to the Japan Sea sediments and its variation during the last 200 ky显示文摘 | Irino T Tada R | 2000 | Geochemical Journal2000，34，1： | 1 |
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