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| 1 | Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman显示文摘A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen. | Atsushi Takahashi Hironobu Saito Yukiko Kanno Kazumichi Abe Junko Yokokawa Atsushi Irisawa Akira Kenjo Takuro Saito Mitsukazu Gotoh Hiromasa Ohira | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Endoscopic ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis: a randomized multicenter trial显示文摘 | S. Doi I. Yasuda H. Kawakami T. Hayashi H. Hisai A. Irisawa T. Mukai A. Katanuma K. Kubota T. Ohnishi S. Ryozawa K. Hara T. Itoi K. Hanada K. Yamao | 2013 | Endoscopy2013，，05： | 8 |
| 3 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 4 | Cronkhite-Canada syndrome associated with myelodysplastic syndrome显示文摘We report a case of Cronkhite-Canada syndrome(CCS)associated with myelodysplastic syndrome(MDS).A 54-year-old woman,diagnosed as MDS the prior year after evaluation of anemia,visited our hospital with the chief complaint of epigastric discomfort.She also had dysgeusia,alopecia,atrophic nail change,and pigmentation of the palm,all of which began several months ago.Blood tests revealed severe hypoalbuminemia.Colonoscopy(CS)showed numerous,dense,red polyps throughout the colon and rectum.Biopsy specimens showed stromal edema,infi ltration of lymphocytes,and cystic dilatation of the crypt.Her clinical manifestations and histology were consistent with CCS.We prescribed corticosteroids,which dramatically improved her physical findings,laboratory data,and endoscopic fi ndings.This is the first report of CCS in a patient with MDS. | Rei Suzuki Atsushi Irisawa Takuto Hikichi Yuta Takahashi Hiroko Kobayashi Hiromi Kumakawa Hiromasa Ohira | 2009 | World Journal of Gastroenterology2009，15，46： | 3 |
| 5 | Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study显示文摘 | I. Yasuda M. Nakashima T. Iwai H. Isayama T. Itoi H. Hisai H. Inoue H. Kato A. Kanno K. Kubota A. Irisawa H. Igarashi Y. Okabe M. Kitano H. Kawakami T. Hayashi T. Mukai N. Sata M. Kida T. Shimosegawa | 2013 | Endoscopy2013，，： | 2 |
| 6 | Usefulness of endoscopic ultrasound to diagnose the severity of chronic pancreatitis显示文摘 | Atsushi Irisawa Kyoko Katakura Hiromasa Ohira Ai Sato Manoop S. Bhutani Lyndon V. Hernandez Masaru Koizumi | 2007 | Journal of Gastroenterology2007，，17： | 2 |
| 7 | Comparative study of diagnostic value of cytologic sampling by endoscopic uhrasonography-guided fine-needle aspiration and that by endoscopic retrograde pancreatography for the management of pancreatic mass without biliary stricture 显示文摘 | Wakatsuki T Irisawa A Bhutani MS | 2005 | J Gastroenterol Hepatol2005，20，11： | 1 |
| 8 | EUS analysis of collateral veins inside and outside the esophagal wall in portal hypertension显示文摘 | Irisawa A obara K Sato Y | | 0，，： | 1 |
| 9 | Postoperative intravesical instillation of THP for superficial bladder tumor:clinical results of prophylactic effects on the recurrence 显示文摘 | Aikawa K Irisawa C Muraki O | 1992 | Gan To Kagaku Ryoho1992，19，4： | 1 |
| 10 | Cardiac pacemaking in the sinoat-rial node显示文摘 | Irisawa H Brown HF Gile W | 1993 | Physiol Rev1993，73，1： | 1 |
| 11 | Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologists显示文摘 | Takuto Hikichi Atsushi Irisawa Manoop S. Bhutani Tadayuki Takagi Goro Shibukawa Go Yamamoto Takeru Wakatsuki Hidemichi Imamura Yuta Takahashi Ai Sato Masaki Sato Tsunehiko Ikeda Yuko Hashimoto Kazuhiro Tasaki Kazuo Watanabe Hiromasa Ohira Katsutoshi Obara | 2009 | Journal of Gastroenterology2009，，4： | 1 |
| 12 | Communicating by electrolarynx with a blind tetraplegic spinal cord injury patient on mechanical ventilation in the ICU显示文摘 | K Shimizu H Ogura T Irisawa | 2013 | Spinal cord : the official journal of the International Medical Society of Paraplegia2013，51，4： | 1 |
| 13 | Primary adenocarcinoma of the minor duodenal papilla显示文摘 | Wakatsuki T Irisawa A Takagi T | 2008 | Yonsei Med J2008，49，2： | 1 |
| 14 | Endoscopic recurrence of esophageal varices is associated with the specific EUS abnormalities; severe peri-esophageal collateral veins and large perforating veins显示文摘 | Irisawa A Saito A obara K | | 0，，： | 1 |
| 15 | Ab initio ^13C and 19F NMR chemical shifts calculations for halogenated pro- panes显示文摘 | Tanuma T Irisawa J Ohnishi K | 2000 | J FluorineChem2000，102，： | 1 |
| 16 | Endoscopic Ultrasound-Guided Oncologic Therapy for Pancreatic Cancer显示文摘 | Rei Suzuki Atsushi Irisawa Manoop S. Bhutani P. J. O’Dwyer | 2013 | Diagnostic and Therapeutic Endoscopy2013，，： | 1 |
| 17 | Small-bowel perforation accompanied by Aspergillus endocarditis in a patient with angioimmunoblastic T-cell lymphoma显示文摘 | Takayuki Saitoh Takafumi Matsushima Asuka Matsuo Akihiko Yokohama Hiroyuki Irisawa Hiroshi Handa Norifumi Tsukamoto Masamitsu Karasawa Yoshihisa Nojima Hirokazu Murakami | 2007 | Annals of Hematology2007，，1： | 1 |
| 18 | Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report显示文摘BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori-negative Ménétrier’s disease are extremely rare.We report a case of early gastric cancer in H.pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected anemia.Contrast-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant rugae.Blood tests showed hypoproteinemia and were negative for serum H.pylori immunoglobulin G antibodies.The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach.UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s disease.En bloc resection with ESD was performed for diagnosis and treatment.Histology of ESD showed well-differentiated tubular adenocarcinoma.The cancer was confined to the mucosa,and complete curative resection was achieved.Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s disease.Three years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.CONCLUSION Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and H.pylori-negative Ménétrier’s disease. | Koh Fukushi Kenichi Goda Hitoshi Kino Masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu Yamagishi Atsushi Irisawa | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 19 | Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing显示文摘 | Takeru Wakatsuki Atsushi Irisawa Hidemichi Imamura Masanori Terashima Goro Shibukawa Tadayuki Takagi Yuta Takahashi Ai Sato Masaki Sato Tsunehiko Ikeda Rei Suzuki Takuto Hikichi Katsutoshi Obara Hiromasa Ohira | 2010 | International Journal of Clinical Oncology2010，，3： | 1 |
| 20 | Endoscopic ultra- sound- guided fine -needle injection of immature dendritic cells into advanced pancreatic cancer refractory to gemcit- abine : a pilot study显示文摘 | Irisawa A Takagi T Kanazawa M | 2007 | Pancreas2007，35，2： | 1 |
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