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| 1 | Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，5： | 1 |
| 2 | Activated polyamidoamine dendriners a nonviral vector for gene transfer to the corneal endotheltum显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，： | 1 |
| 3 | Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2 + oscillations显示文摘 | BRAUD S ISAAC JOHN T R | 2005 | J Biol Chem2005，280，25： | 1 |
| 4 | Tocopherols modulate extra- plastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature显示文摘 | Maeda H Sage T L Isaac G | 2008 | Plant Cell2008，20，2： | 1 |
| 5 | Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, pho- tochemistry, and biochemistry 显示文摘 | Cimino G D Gamper H B Isaacs S T | 1985 | Annu Rev Biocbem1985，54，： | 1 |
| 6 | Differential effects of atrial and brain natriuretic peptides on human pulmonary artery:An in vitro study显示文摘BACKGROUND The prevalence of cardiovascular diseases,especially heart failure,continues to rise worldwide.In heart failure,increasing levels of circulating atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are associated with a worsening of heart failure and a poor prognosis.AIM To test whether a high concentration of BNP would inhibit relaxation to ANP.METHODS Pulmonary arteries were dissected from disease-free areas of lung resection,as well as pulmonary artery rings of internal diameter 2.5–3.5 mm and 2 mm long,were prepared.Pulmonary artery rings were mounted in a multiwire myograph,and a basal tension of 1.61gf was applied.After equilibration for 60 min,rings were pre-constricted with 11.21μmol/L PGF2α(EC80),and concentration response curves were constructed to vasodilators by cumulative addition to the myograph chambers.RESULTS Although both ANP and BNP were found to vasodilate the pulmonary vessels,ANP is more potent than BNP.pEC50 of ANP and BNP were 8.96±0.21 and 7.54±0.18,respectively,and the maximum efficacy(Emax)for ANP and BNP was-2.03 gf and-0.24 gf,respectively.After addition of BNP,the Emax of ANP reduced from-0.96gf to-0.675gf(P=0.28).CONCLUSION BNP could be acting as a partial agonist in small human pulmonary arteries,and inhibits relaxation to ANP.Elevated levels of circulating BNP could be responsible for the worsening of decompensated heart failure.This finding could also explain the disappointing results seen in clinical trials of ANP and BNP analogues for the treatment of heart failure. | Azar Hussain Robert T Bennett Zaheer Tahir Emmanuel Isaac Mubarak A Chaudhry Syed S Qadri Mahmoud Loubani Alyn H Morice | 2019 | World Journal of Cardiology2019，11，10： | 1 |
| 7 | Psoralens as photoactive probes of nucleic acid structure and function : organic chemistry, photochemistry, and biochemistry显示文摘 | Cimino G D Gamper H B Isaacs S T | 1985 | Annu Rev Biochem1985，54，1： | 1 |
| 8 | Autosomal recessive distal myopathy 显示文摘 | Isaacs H Badenhorst M Whistler T | 1988 | J Clin Pathol1988，41，： | 1 |
| 9 | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature显示文摘 | Maeda H Sage T L Isaac G | 2008 | Plant Cell2008，20，： | 1 |
| 10 | A Pareto comer search evolution- ary algorithm and dimensionality reduction in many-objective optimization problems 显示文摘 | Singh H K Isaacs A Ray T | 2011 | lEvEE Transactions on Evolutionary Computation2011，15，4： | 1 |
| 11 | Mesenchymal stem cellsas a vector for the inflammatory prostate microenvironment 显示文摘 | Brennen W N Denmeade S H Isaacs J T | 2013 | Endocr Relat Cancer2013，20，5： | 1 |
| 12 | Determining the terahertz optical properties of subwavelength films using semiconductor surface plasmons显示文摘 | Isaac T H Barnes W L and Hendry E | 2008 | Appl Phys Lett2008，93，24： | 1 |
| 13 | Surface plasmon mediated transmission of subwavelength slits at THz frequencies显示文摘 | Isaac T H Rivas J G Sambles J R | 2008 | Phys Rev B2008，77，11： | 1 |
| 14 | Effect of Ionizing Radiation on the Allergenieity of Milk Protein显示文摘 | KRAYBILL H F LINDER R O READ M S SHAW T M ISAAC G J | 1959 | Journal of Dairy Science1959，42，4： | 1 |
| 15 | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature显示文摘 | Maeda H Sage T L Isaac G Welti R Dellapenna D | | 0，，： | 1 |
| 16 | Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and Biochemistry显示文摘 | G D Cimino H B Gamper S T Isaacs J E Hearst | 1985 | Annual Review of Biochemistry1985，，： | 1 |
| 17 | High-throughput single cell arrays as a novel tool in biopreservation显示文摘 | Kenneth L R Kevin R K Korkut U Steven C H Isaac S K Martin L Y Mehmet T | 2009 | Cryobiology2009，58，3： | 1 |
| 18 | A Pareto corner search evolutionary algorithm and dimensionality re-duction in many objective optimization problems 显示文摘 | SINGH H K ISAACS A RAY T | 2011 | IEEE Transactions on Evolutionary Computation2011，15，4： | 1 |
| 19 | Precise manipulation of chromosomes in vivo enables genome-wide codon replacement 显示文摘 | Isaacs F J Carr P A Wang H H Lajoie M J Sterling B Kraal L Tolonen A C Gianoulis T A Goodman D B Reppas N B | 2011 | Science2011，333，6040： | 1 |
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