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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Determination of a wide range of volatile organic compounds in ambient air using multisorbent adsorption/thermal desorption and gas chromatography mass spectrometry显示文摘 | Pankow J F Luo W T Isabelle L M | 1998 | Analytical Chemistry1998，70，24： | 1 |
| 5 | Determination of a wide range of volatile organic compounds in ambient air using multisorbent adsorption/thermal desorption andgas chromatography/mass spectrometry 显示文摘 | Pankow J F Luo Wen Tai Isabelle L M | 1998 | Anal Chem1998，70，24： | 1 |
| 6 | Lipid peroxidation,stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis显示文摘 | Jacob G Natasha P Nghi P Isabelle L Jing YH Geoffrey F | 2003 | J Hepatol2003，39，： | 1 |
| 7 | A role for the DOF transcription factor BPBF in the regulation of gibberellin-responsive genes in barley aleurone显示文摘 | MENA M CEJUDO F J ISABEL L I | 2002 | Plant Physiology2002，130，： | 1 |
| 8 | Evidence ofpresence of poliovirus genomic sequences in cerebrospinal fluidfrom patients with postpolio syndrome显示文摘 | ISABELLE L G JEAN J FLORENCE F | 1996 | Clin Microbiology1996，34，： | 1 |
| 9 | Changes in endocarmabinoid transmission in the basal ganglia in a rat model of Huntington's disease显示文摘 | Isabel L Filomena F Maribel C | 2001 | Neuroreport2001，12，10： | 1 |
| 10 | StLrfactin, a novel isoform from Bacillus subtilis studied by mass and NMR spectroscopies显示文摘 | Peypoux F Bonmatin J M Isabelle H L | 1994 | Europeandournal of Biochemistry1994，224，1： | 1 |
| 11 | Effects of the combination of hydrophobic polypeptides,iso-αacids,and malto-oligosaccharides on beer foam stability显示文摘 | Isabel M P L V O F Erreira Kaa Tia Jorge Luciana C Nogueira | 2005 | J Agric Food Chem2005，53，12： | 1 |
| 12 | Determination of a wide range of volatile organic compounds in ambient air using multisorbent adsorption/thermal desorption and gas chromatography/mass spectrometry 显示文摘 | Pankow J F Luo Wen Tai Isabelle L M | 1998 | AnalChem1998，70，24： | 1 |
| 13 | Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma-like carcinoma of uterine cervix: report of two cases and review of the literature 显示文摘 | Jean-Christophe N Laurence L Isabelle F | 2001 | Human Pathology2001，32，1： | 1 |
| 14 | Targeted sequencing supports morphology and embryo features in resolving the classification of Cyperaceae tribe Fuireneae s.l.显示文摘Molecular phylogenetic studies based on Sanger sequences have shown that Cyperaceae tribe Fuireneae s.l.is paraphyletic.However,taxonomic sampling in these studies has been poor,topologies have been inconsistent,and support for the backbone of trees has been weak.Moreover,uncertainty still surrounds the morphological limits of Schoenoplectiella,a genus of mainly small,amphicarpic annuals that was recently segregated from Schoenoplectus.Consequently,despite ample evidence from molecular analyses that Fuireneae s.l.might consist of two to four tribal lineages,no taxonomic changes have yet been made.Here,we use the Angiosperms353 enrichment panel for targeted sequencing to(i)clarify the relationships of Fuireneae s.l.with the related tribes Abildgaardieae,Eleocharideae,and Cypereae;(ii)define the limits of Fuireneae s.s.,and(iii)test the monophyly of Fuireneae s.l.genera with emphasis on Schoenoplectus and Schoenoplectiella.Using more than a third of Fuireneae s.l.diversity,our phylogenomic analyses strongly support six genera and four major Fuireneae s.l.clades that we recognize as tribes:Bolboschoeneae stat.nov.,Fuireneae s.s.,Schoenoplecteae,and Pseudoschoeneae tr.nov.These results are consistent with morphological,micromorphological(nutlet epidermal cell shape),and embryo differences detected for each tribe.At the generic level,most sub-Saharan African perennials currently treated in Schoenoplectus are transferred to Schoenoplectiella.Our targeted sequencing results show that these species are nested in Schoenoplectiella,and their treatment here is consistent with micromorphological and embryo characters shared by all Schoenoplectiella species.Keys to recognized tribes and genera are provided. | Julian R.Starr Pedro Jiménez-Mejías Alexandre R.Zuntini Étienne Léveillé-Bourret Ilias Semmouri Muthama Muasya William J.Baker Grace E.Brewer Niroshini Epitawalage Isabel Fairlie Félix Forest Izai A.B.Sabino Kikuchi Lisa Pokorny Isabel Larridon | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
| 15 | A new classification of Cyperaceae (Poales) supported by phylogenomic data显示文摘Cyperaceae(sedges)are the third largest monocot family and are of considerable economic and ecological importance.Sedges represent an ideal model family to study evolutionary biology due to their species richness,global distribution,large discrepancies in lineage diversity,broad range of ecological preferences,and adaptations including multiple origins of C4 photosynthesis and holocentric chromosomes.Goetghebeur′s seminal work on Cyperaceae published in 1998 provided the most recent complete classification at tribal and generic level,based on a morphological study of Cyperaceae inflorescence,spikelet,flower,and embryo characters,plus anatomical and other information.Since then,several family-level molecular phylogenetic studies using Sanger sequence data have been published.Here,more than 20 years after the last comprehensive classification of the family,we present the first family-wide phylogenomic study of Cyperaceae based on targeted sequencing using the Angiosperms353 probe kit sampling 311 accessions.In addition,62 accessions available from GenBank were mined for overlapping reads and included in the phylogenomic analyses.Informed by this backbone phylogeny,a new classification for the family at the tribal,subtribal,and generic levels is proposed.The majority of previously recognized suprageneric groups are supported,and for the first time,we establish support for tribe Cryptangieae as a clade including the genus Koyamaea.We provide a taxonomic treatment including identification keys and diagnoses for the 2 subfamilies,24 tribes,and 10 subtribes,and basic information on the 95 genera.The classification includes five new subtribes in tribe Schoeneae:Anthelepidinae,Caustiinae,Gymnoschoeninae,Lepidospermatinae,and Oreobolinae. | Isabel Larridon Alexandre R.Zuntini Étienne Léveillé-Bourret Russell L.Barrett Julian R.Starr AMuthama Muasya Tamara Villaverde Kenneth Bauters Grace E.Brewer Jeremy J.Bruhl Suzana M.Costa Tammy L.Elliott Niroshini Epitawalage Marcial Escudero Isabel Fairlie Paul Goetghebeur Andrew LHipp Pedro Jiménez-Mejías Izai ABSabino Kikuchi Modesto Luceño JoséIgnacio Márquez-Corro Santiago Martín-Bravo Olivier Maurin Lisa Pokorny Eric HRoalson Ilias Semmouri David A.Simpson Daniel Spalink WWayt Thomas Karen L.Wilson Martin Xanthos Félix Forest William J.Baker | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
| 16 | Influence of pyrolysis temperature on biochar property andfunction as a heavy metal sorbent in soil显示文摘 | Minori U Lynda H W K Thomas K Chanel A F Isabel M L | 2011 | Journal of Agricultural and Food Chemistry2011，59，： | 1 |
| 17 | Conversion of nicotine in tobacco smoke to its volatile and available free - base form through the action of gaseous ammonia 显示文摘 | PANKOW J F MADER B T ISABELLE L M | 1997 | Environ Sci Technol1997，31，： | 1 |
| 18 | In-capillary derivatization approach applied to the analysis of insulin by capillary electrophoresis with laser-induced fluorescence deteetion显示文摘 | ISABELLE L P GISELE F CLAIRE S | 2004 | Journal of Chromatography A2004，1046，12： | 1 |
| 19 | Structure and dif- ferential expression of two maize ferritin genes in response to iron and abscisic acid 显示文摘 | Isabelle F L Loridon K Lobreaux S | 1995 | European Journal of Biochemistry1995，232，3： | 1 |
| 20 | Logisticregression models for human-caused wildfire risk estimation : an-alysing the effect of the spatial accuracy in fire occurrence data显示文摘 | del Hoyo L V Martin Isabel M Javier Martinez Vega F | 2011 | European Journal of Forest Research2011，130，6： | 1 |
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