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| 1 | Personalized surgical management of colorectal cancer in elderly population显示文摘Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric population.In this phase of the life cycle,treatment is frequently suboptimal.Despite the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently encountered.On the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent disability.Unfortunately,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these patients.The objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the elderly.More than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by CRC.Although cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life. | Giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo Veronese Isacco Montroni | 2014 | World Journal of Gastroenterology2014，20，14： | 5 |
| 2 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 3 | Telomere-Specific Reverse Transcriptase (hTERT) and Cell-free RNA in Plasma as Predictors of Pathologic Tumor Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy显示文摘 | Salvatore Pucciarelli Enrica Rampazzo Marta Briarava Isacco Maretto Marco Agostini Maura Digito Sonia Keppel Maria Friso Sara Lonardi Antonino Paoli Claudia Mescoli Donato Nitti Anita Rossi | 2012 | Annals of Surgical Oncology2012，，9： | 2 |
| 4 | The Challenge of Education in Colorectal Cancer Surgery: A Comparison of Early Oncological Results, Morbidity, and Mortality Between Residents and Attending Surgeons Performing an Open Right Colectomy显示文摘 | Isacco Montroni Federico Ghignone Giancarlo Rosati Davide Zattoni Alessio Manaresi Mario Taffurelli Giampaolo Ugolini | 2013 | Journal of Surgical Education2013，，： | 1 |
| 5 | Dental-derived stem cells and biowaste biomaterials:What’s next in bone regenerative medicine applications显示文摘The human teeth and oral cavity harbor various populations of mesenchymal stem cells(MSCs),so called dental-derived stem cells(D-dSCs)with self-renewing and multilineage differentiation capabilities.D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment.Altogether,this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes,and offers information regarding the available scientific data and possible applications. | MICHELE DI COSOLA STEFANIA CANTORE MARIO GIOSUÈBALZANELLI CIRO GARGIULO ISACCO KIEU CAO DIEM NGUYEN RAJIV SAINI ANNARITA MALCANGI MARGHERITA TUMEDEI MARIATERESA AMBROSINO ANTONIO MANCINI SALVATORE SCACCO RICCARDO NOCINI LUIGI SANTACROCE ANDREA BALLINI EDOARDO BRAUNER | 2022 | BIOCELL2022，46，4： | 1 |
| 6 | Functional characterization of three Italian Populoz alba L genotypes under salinity stress显示文摘 | Isacco B Moica Piazzai Simona Benucci et at | 2007 | Trees-Structure and Function2007，21，： | 1 |
| 7 | Telomere-Specific Reverse Transcriptase (hTERT) and Cell-free RNA in Plasma as Predictors of Pathologic Tumor Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy显示文摘 | Salvatore Pucciarelli Enrica Rampazzo Marta Briarava Isacco Maretto Marco Agostini Maura Digito Sonia Keppel Maria Friso Sara Lonardi Antonino Paoli Claudia Mescoli Donato Nitti Anita Rossi | 2012 | Annals of Surgical Oncology2012，，9： | 1 |
| 8 | Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer显示文摘 | Fabio Pomerri Salvatore Pucciarelli Isacco Maretto Michela Zandonà Paola Del Bianco Luca Amadio Massimo Rugge Donato Nitti Pier C. Muzzio | 2011 | Surgery2011，，1： | 1 |
| 9 | Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer显示文摘 | Fabio Pomerri Salvatore Pucciarelli Isacco Maretto Michela Zandonà Paola Del Bianco Luca Amadio Massimo Rugge Donato Nitti Pier C. Muzzio | 2011 | Surgery2011，，1： | 1 |
| 10 | Identification by a Digital Gene Expression Displayer (DGED) and testby RT-PCR analysis of new mRNA candidate markers for colorectal cancer in peripheralblood显示文摘 | Mattia Lauriola Giampaolo Ugolini Giancarlo Rosati Simone Zanotti Isacco Montroni Alessio Manaresi Davide Zattoni Stefano Rivetti Gabriella Mattei Domenico Coppola Pierluigi Strippoli Mario Taffurelli Rossella Solmi | 2010 | International Journal of Oncology2010，，2： | 1 |
| 11 | Urban fathers' role in maternal postpartummental health 显示文摘 | Garfield CF Isacco A | 2009 | Fathering: A Journal of Theory Research and Practice about Men as Fathers2009，7，3： | 1 |
| 12 | Work Space,Satisfaction & Productivity in Libraries 显示文摘 | Isacco J M | 1985 | Library Journal1985，110，8： | 1 |
| 13 | Electrocatalytic oxidation of salicylic acid by a cobalt hydrotaleite-like compound modified Pt electrode 显示文摘 | Isacco Gualandi Erika Scavetta Sergio Zappoli | 2011 | Biosensors and Bioelectronics2011，26，7： | 1 |
| 14 | 免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究显示文摘背景与目的 通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法 对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果 共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。 | Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) | 2022 | 中国肺癌杂志2022，25，4： | 0 |
| 15 | COVID-19 (SARS-CoV-2 infection) in lymphoma patients: A review显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection now has a global resonance and represents a major threat for several patient populations.Observations from initial case series suggested that cancer patients in general might have an unfavorable outcome following coronavirus disease 2019(COVID-19),due to their underlying conditions and cytotoxic treatments.More recently,data regarding the incidence and clinical evolution of COVID-19 in lymphomas have been reported with the aim to identify those more frequently associated with severe complications and death.Patients with lymphoma appear particularly vulnerable to SARS-CoV-2 infection,only partly because of the detrimental effects of the anti-neoplastic regimens(chemotherapy,pathway inhibitors,monoclonal antibodies)on the immune system.Here,we systematically reviewed the current literature on COVID-19 in adult patients with lymphoma,with particular emphasis on disease course and prognostic factors.We also highlighted the potential differences in COVID-19 clinical picture according to lymphoma subtype,delivered treatment for the hematological disease and its relationship on how these patients have been managed thus far. | Valentina Bonuomo Isacco Ferrarini Michele Dell'Eva Eugenio Sbisà Mauro Krampera Carlo Visco | 2021 | World Journal of Virology2021，10，6： | 0 |
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