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| 1 | Nestin:A novel angiogenesis marker and possible target for tumor angiogenesis显示文摘Abnormal vasculature,termed tumor vessels,is a hallmark of solid tumors.The degree of angiogenesis is associated with tumor aggressiveness and clinical outcome.Therefore,exact quantification of tumor vessels is useful to evaluate prognosis.Furthermore,selective detection of newly formed tumor vessels within cancer tissues using specific markers raises the possibility of molecular targeted therapy via the inhibition of tumor angiogenesis.Nestin,an intermediate filament protein,is reportedly expressed in repair processes,various neoplasms,and proliferating vascular endothelial cells.Nestin expression is detected in endothelial cells of embryonic capillaries,capillaries of the corpus luteum,which replenishes itself by angiogenesis,and proliferating endothelial progenitor cells,but not in mature endothelial cells.Therefore,expression of nestin is relatively limited to proliferating vascular endothelial cells and endothelial progenitor cells.Nestin expression is also reported in blood vessels within glioblastoma,prostate cancer,colorectal cancer,and pancreatic cancer,and its expression is more specific for newly formed blood vessels than other endothelial cell markers.Nestin-positive blood vessels form smaller vessels with high proliferation activity in tumors.Knockdown of nestin in vascular endothelial cells suppresses endothelial cell growth and tumor formation ability of pancreatic cancers in vivo.Using nestin to more accurately evaluate microvessel density in cancer specimens may be a novel prognostic indicator.Furthermore,nestin-targeted therapy may suppress tumor proliferation via inhibition of angiogenesis in numerous malignancies,including pancreatic cancer.In this review article,we focus on nestin as a novel angiogenesis marker and possible therapeutic target via inhibition of tumor angiogenesis. | Yoko Matsuda Masahito Hagio Toshiyuki Ishiwata | 2013 | World Journal of Gastroenterology2013，19，1： | 16 |
| 2 | Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis显示文摘Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological conditions, nestin is expressed in repair processes in the CNS, muscle, liver, and infarcted myocardium. Furthermore, increased nestin expression has been reported in various tumor cells, including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanoma, dermatofibrosarcoma protuberances, and thyroid tumors. Nestin is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors; however, the roles of nestin in cancer cells have not been well characterized. Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers. These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis. It has received a lot of attention recently as a cancer stem cell marker in various cancer cells including brain tumors, malignant rhabdoid tumors, and uterine, cervical, prostate, bladder, head and neck, ovarian, testicular, and pancreatic cancers. The purpose of this review is to clarify the roles of nestin in cancer cells and in tumor angiogenesis, and to examine the association between nestin and cancer stem cells. Nestin has the potential to serve as a molecular target for cancers with nestin-positive cancer cells and nestin-positive tumor vasculature. | Toshiyuki Ishiwata Yoko Matsuda Zenya Naito | 2011 | World Journal of Gastroenterology2011，17，4： | 11 |
| 3 | On a kind of severe flacherie (sotto disease)显示文摘 | ISHIWATA S | 1901 | Dainihon Sanshi Kaiho1901，114，： | 1 |
| 4 | Urinary Bladder Carcinogenesis Induced By Melamine in F344 Male Rats: Correlation Between Carcinogenicity and Urolith Formation 显示文摘 | Ogasawara H Imaida K Ishiwata H | 1995 | Carcinogenesis1995，16，11： | 1 |
| 5 | Identity of antibiotic P-42-1 elaborated by Actinomyces tumemacerans with kanchanomycin and albofimgin显示文摘 | Fukushima K Ishiwata K Kuroda S | 1973 | J Antibiot (Tokyo)1973，26，2： | 1 |
| 6 | The helix-loop-helix protein Id2 is over expressed in human pancreatic cancer显示文摘 | Kleeff J Ishiwata T Friess H | 1998 | Cancer Res1998，58，17： | 1 |
| 7 | Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes 显示文摘 | Yasumitsu Ogra AE Kazuya Ishiwata Jorge Ruiz Encinar | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 8 | Biohydrogen production from waste materials 显示文摘 | Tanisho S Ishiwata Y | 1995 | International Journal of Hydrogen Energy1995，20，7： | 1 |
| 9 | Strength properties of yttrium-oxide- dispersed tungsten alloy 显示文摘 | Itoh Y Ishiwata Y | 1996 | JSME International Journal Series A1996，39，： | 1 |
| 10 | Tumor angiogenesis factors produced by cancer cells 显示文摘 | Ishiwata I Sudo T Kiguchi K | 1999 | Hum Cell1999，12，1： | 1 |
| 11 | GATA4 is adosage-sensitive regulator of cardiac morphogenesis显示文摘 | Pu WT Ishiwata T Juraszek AL Ma Q Izumo S | 2004 | Dev Biol2004，275，1： | 1 |
| 12 | Postangioplasty restenosis: platelet activation and the coagulation-fibrinolysis system as possible factors in the pathogenesis of restenosis 显示文摘 | Ishiwata S Tukada T Nakanishi S | 1997 | Am Heart J1997，133，4： | 1 |
| 13 | Differential localization of transforming growth factor beta isoforms in human gastric mucosa and ovcrprcssion in gastric carcinoma 显示文摘 | Naef M Ishiwata T Fricss H | 1997 | Int J Cancer1997，71，2： | 1 |
| 14 | Application of a recombinant Fob fragment from a phage display library forsensitive detection of a target antigen by an inhibition ELISA system 显示文摘 | Itoh K Suzuki K Ishiwata S | 1999 | J Immunol Methods1999，223，1： | 1 |
| 15 | 查看详情显示文摘 | Tanisho S Ishiwata Y | | 0，，： | 1 |
| 16 | Differentiation of mesenchymal cells derived from human amniotic membranes into hepatocyte-like ceils in vitro显示文摘 | Tamagawa T Oi S Ishiwata I | 2007 | Hum Ce112007，20，3： | 1 |
| 17 | Effects of cyclodextrins on photodegradation of organophosphorus pesticides in humic water 显示文摘 | KAMIYA M KAMEYAMA K ISHIWATA S | 2001 | Chemosphere2001，42，3： | 1 |
| 18 | Serotonin release in the preoptic area and anterior hypothalamus is not involved in thermoregulation during low - intensity exercise in a warm environment显示文摘 | Takatsu S Ishiwata T Meeusen R | 2010 | Neurosci Lett2010，482，1： | 1 |
| 19 | Continuous hydrogen production from molasses by fermentation using urethane foam as a support of flocks 显示文摘 | TANISHO S ISHIWATA Y | 1995 | Int J Hydrogen Energy1995，20，7： | 1 |
| 20 | Continuous hydrogen production from molas- ses by fermentation using urethane foam as a support of flocks 显示文摘 | Tanisho S Ishiwata Y | 1995 | International Journal of Hydrogen Energy1995，，20： | 1 |
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