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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | RRR-alpha-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways显示文摘 | Israel K Sanders B G Kline K | 1995 | Nutr Cancer1995，24，2： | 1 |
| 5 | Fast -track surgery may reduce complications following major colonic surgery显示文摘 | Zargar- Shoshtari K Cormolly A B Israel L H | 2008 | Dis Colon Rectum2008，51，11： | 1 |
| 6 | Impact of lalI -SPECT/CT images obtained with an integrat- ed system in the follow-up of patients with thyroid carcinoma 显示文摘 | Tharp K Israel O Hausmann J | 2004 | Eur J Nucl Med Mol Imaging2004，31，10： | 1 |
| 7 | Fast track surgery may reduce comp- lications following major co- lonic surgery 显示文摘 | Zargar Shoshtari K Connolly AB Israel LH | 2008 | Dis Colon Rectum2008，51，11： | 1 |
| 8 | Fast-track sur- gery may reduce complications following major colonic surgery 显示文摘 | Zargar-shoshtari K Conolly AB Israel LH | 2008 | Dis Colon Rectum2008，51，11： | 1 |
| 9 | Fast track surgery may reduce complications following major colonic surgery显示文摘 | Zargar Shoshtari K Connolly AB Israel LH | 2008 | Dis Colon Rectum2008，51，11： | 1 |
| 10 | Cr08 one year experience with fast-track surgery for elective colonic resection显示文摘 | Zargar Shoshtari K Connolly AB Israel LH | 2007 | ANZJ Sur2007，77，1： | 1 |
| 11 | Serum IgA,IgG,and IgM antibodies directed against acetaldehyde-derived epitopes:relationship to liver disease severity and alcohol consumption显示文摘 | Viitala K Israel Y Blake JE | 1997 | Hepatology1997，25，： | 1 |
| 12 | Biochemical aspects of fumaric acid accumulation by Rhizopus arrhizus 显示文摘 | William K Eli Z Israel G | 1986 | Applied and Environmental Microbiology1986，52，1： | 1 |
| 13 | Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo显示文摘 | ISRAEL D I NOVE J KERNS K M | 1996 | Growth Factors1996，13，34： | 1 |
| 14 | Delayed and ad- vanced sleep phase symptoms 显示文摘 | ANDO K KRIPKE D F ANCOLI ISRAEL S | 2002 | Isr J Psychiatry Relat Sci2002，39，1： | 1 |
| 15 | Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to- moderate asthma 显示文摘 | Asano K Lilly CM O'Donnell WJ Israel E Fischer A Ransil B J | 1995 | J Allergy Clin Immunol1995，96，51： | 1 |
| 16 | Vitamin E succinate induces apoptosis in human prostate cancer cells:role for Fas in vitamin E succinate triggered apoptosis显示文摘 | Israel K Yu W Sanders BG | 2000 | Nutr Cancer2000，36，1： | 1 |
| 17 | Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo 显示文摘 | Israel D I Nove J Kerns K M | 1996 | Growth Factors1996，13，34： | 1 |
| 18 | Fast-track sur- gery may reduce complications following major colonic surgery 显示文摘 | Zargar-Shoshtari K Connolly AB Israel LH | 2008 | Dis Colon Rectum2008，51，11： | 1 |
| 19 | Biochemical aspects of fumaric acid accumulation by Rhizopus arrhizus 显示文摘 | William K Eli Z Israel G | 1986 | Applied and Environmental Microbiology1986，52，1： | 1 |
| 20 | Fast-track surgery may reduce complications following major colonic sur- gery 显示文摘 | Zargar-Shoshtari K Connolly AB Israel LH | 2008 | Dis Colon Rectum2008，51，11： | 1 |
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