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| 1 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 2 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 3 | Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation显示文摘AIM:To investigate genetic diversity of Helicobacter pylori (H.pylori) cell division-related gene A (cdrA) and its effect on the host response.METHODS:Inactivation of H.pylori cdrA,which is involved in cell division and morphological elongation,has a role in chronic persistent infections.Genetic property of H.pylori cdrA was evaluated using polymerase chain reaction and sequencing in 128 (77 American and 51 Japanese) clinical isolates obtained from 48 and 51 patients,respectively.Enzyme-linked immunosorbent assay was performed to measure interleukin-8 (IL-8) secretion with gastric biopsy specimens obtained from American patients colonized with cdrA-positive or-negative strains and AGS cells cocultured with wild-type HPK5 (cdrA-positive) or its derivative HPKT510 (cdrA-disruptant).Furthermore,the cytotoxin-associated gene A (cagA) status (translocation and phosphorylation) and kinetics of transcription factors [nuclear factor-kappa B (NF-κB) and inhibition kappa B] were investigated in AGS cells co-cultured with HPK5,HPKT510 and its derivative HPK5CA (cagA disruptant) by western blotting analysis with immunoprecipitation.RESULTS:Genetic diversity of the H.pylori cdrA gene demonstrated that the cdrA status segregated into two categories including four allele types,cdrA-positive (allele types;Ⅰand Ⅱ) and cdrA-negative (allele types;Ⅲ and Ⅳ) categories,respectively.Almost all Japanese isolates were cdrA-positive (Ⅰ:7.8% and Ⅱ:90.2%),whereas 16.9% of American isolates were cdrA-positive (Ⅱ) and 83.1% were cdrA-negative (Ⅲ:37.7% and Ⅳ:45.5%),indicating extended diversity of cdrA in individual American isolates.Comparison of each isolate from different regions (antrum and corpus) in the stomach of 29 Americans revealed that cdrA status was identical in both isolates from different regions in 17 cases.However,12 cases had a different cdrA allele and 6 of them exhibited a different cdrA category between two regions in the stomach.Furthermore,in 5 of the 6 cases possessing a different cdrA category,cdrA-negative isolate existed in the corpus,suggesting that cdrA-negative strain is more adaptable to colonization in the corpus.IL-8 secretions from AGS revealed that IL-8 levels induced by a cdrA-disrupted HPKT510 was significantly lower (P < 0.01) compared to wildtype HPK5:corresponding to 50%-60% of those of wild-type HPK5.These data coincided with in vivo data that an average value of IL-8 in biopsy specimens from cdrA-positive and cdrA-negative groups was 215.6 and 135.9 pg/mL,respectively.Western blotting analysis documented that HPKT510 had no effect on CagA translocation and phosphorylation,however,nuclear accumulation of NF-κB was lower by HPKT510 compared to HPK5.CONCLUSION:Colonization by a cdrA-negative or cdrA-dysfunctional strain resulted in decreased IL-8 production and repression of NF-κB,and hence,attenuate the host immunity leading to persistent infection. | Hiroaki Takeuchi Ya-Nan Zhang Dawn A Israel Richard M Peek Jr Mikio Kamioka Hideo Yanai Norihito Morimoto Tetsuro Sugiura | 2012 | World Journal of Gastroenterology2012，18，5： | 3 |
| 4 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 5 | Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of pS0 NF-kappaB 显示文摘 | MacKichan M L Logeat F Israel A | 1996 | J Biol Chem1996，271，11： | 1 |
| 6 | Lost-motion VVT diesel engine retarder:an integrated engine retarding system provides optimized performance while consuming less space显示文摘 | Vorih J M Israel M A | 1998 | Automotive Engineering1998，106，1： | 1 |
| 7 | The use of cytokines and che mokines as genetic adjuvants for plasmid DNA vaccines显示文摘 | Egan M A Israel Z R | 2002 | Clinical and Applied Immunology Reviews2002，2，45： | 1 |
| 8 | ECG to Identify Individuals显示文摘 | Israel S A lrvine J M Cheng A | 2005 | Pattern Recognition2005，38，1： | 1 |
| 9 | Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1979 | Science1979，203，4383： | 1 |
| 10 | Effect of AT(1) angiotensin Ⅱ receptor antagonists on the sympathetic response to a cold pressor test in healthy volunteers显示文摘 | Israel A Zavala L E Cierco M | | 0，，02： | 1 |
| 11 | The use of cytokines and chemokines as genetic adjuvants for plasmid DNA vaccines显示文摘 | Egan M A Israel Z R | 2002 | Clin Appl Immunol Rev2002，，2： | 1 |
| 12 | Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system显示文摘 | Chan H W Israel M A Garon C F | 1979 | Science1979，203，4383： | 1 |
| 13 | An update of the Bosniak renal cyst classification system显示文摘 | Israel Gary M Bosniak Morton A | 2005 | Urology2005，66，3： | 1 |
| 14 | An update of the bosniak renal cyst classification system显示文摘 | Israel G M Bosniak M A | 2005 | Urology2005，66，3： | 1 |
| 15 | Relationship of cortical thickness of the proximal humerus and pullout strength of a locked plate and screw construct显示文摘 | Wallace M J Bledsoe G Moed B R Israel H A Kaar S G | 2012 | J Orthop Trauma2012，26，： | 1 |
| 16 | Growth, photosynthetic properties and Rubisco activities and amounts of marine macroalgae grown under current and elevated seawater CO2 concentrations显示文摘 | Israel A Hophy M | 2002 | Global Change Biological2002，8，9： | 1 |
| 17 | Clinical and immunopathological aspects of hypersensitivity pneumonitis显示文摘 | Lacasse Y Israel Assayag E Laviolette M et a l | 2004 | Rev Mal Respir2004，21，： | 1 |
| 18 | Photosynthetic inorganic carbon utilization and growth of Porphyra linearis (Rhodophyta)显示文摘 | Israel A Katz S Dubinsky Z Merrill J E Friedlander M | 1999 | Journal of Applied Phycology1999，11，： | 1 |
| 19 | What is Invexity显示文摘 | Ben- Israel M A Mond B | 1986 | Journal of the Australian Mathematical Socienty1986，28，： | 1 |
| 20 | Pseudo polar based estimation of large translations rotations and scalings in images 显示文摘 | KELLER Y AVERBUCH A ISRAELL M | 2005 | IEEE Transactions on Image Processing2005，14，1： | 1 |
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