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| 1 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 2 | Activated liver stellate cells in chronic viral C hepatitis:histopathological and immunohistochemical study 显示文摘 | Nada R T Ivan V B Dimitrije C B | 2009 | J Gastrointestin Liver Dis2009，18，2： | 1 |
| 3 | Gene Expression Study of Aurora-A Reveals Implication During Bladder Carcinogenesis Implication During Bladder Carcinogenesis Urothelial Cancer 显示文摘 | Eva C Ivan B Delphine D | 2008 | Urology2008，72，4： | 1 |
| 4 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 5 | Identification and characterization of a Drosophila ortholog of W RN exonuclease that is required to maintain genome integrity显示文摘 | Robert DC Ivan B David J C | 2008 | Aging cell2008，7，3： | 1 |
| 6 | The reduction of silica carbon and silicon carbide 显示文摘 | Patrick D M Lee J G Ivan B C | 1979 | J Am Ceram Soc1979，62，34： | 1 |
| 7 | Helical CT with multiplanar and three-dimensional reconstruction of nonneoplastic abnormalities of the trachea显示文摘 | Gilbert RF Ivan B Max C | 2001 | J Comput Assist Tomogr2001，25，2： | 1 |
| 8 | Virtual machines for distributed real-time systems 显示文摘 | Marco C Ivan C B | 2009 | Computer Standards & Interfaces2009，31，1： | 1 |
| 9 | Chemical and Physical Characterization of Aphron-Based Drilling Fluids显示文摘 | Ivan C D Frederick B and James E | 2002 | SPE 77455 Presented at 2002 SPE Annual Technical conference and Exihibition San Antonio Teras2002，9，： | 1 |
| 10 | Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience显示文摘 | Ivan C Ann R Craig B | 1997 | Neurosurgery1997，40，2： | 1 |
| 11 | Effect of lyophilised vaccinium berries on memory, anxiety and locomotion in adult rats 显示文摘 | ROSANA R M IVAN I MARIA C B | 2005 | Pharmacol Res2005，52，6： | 1 |
| 12 | Effect of lyophilisd Vaccinium berries on memory,anxiety and locomotion in adult rats显示文摘 | MARIA R R IVAN I MARIA C B R | 2005 | Pharmacological Research2005，52，： | 1 |
| 13 | Fixed-length payload encoding for low-jitter controller area network communication显示文摘 | GIANLUCA C IVAN B | 2013 | IEEE Transactions on Industrial Informatics2013，9，4： | 1 |
| 14 | Comparison of common carotid artery Intima-media thickness between Brazilian Euro-descendants and Mrodescendants withatherosclerosis risk factors显示文摘 | IVAN B C YUMIKO Y ALECXANDER V | | 0，，： | 1 |
| 15 | A novel extraction-based procedure for the determination of trace elements in estuarine sediment samples by ICP-MS显示文摘 | MORGANA F DAIANE P C Q IVAN N B C | 2014 | Microchemical Journal2014，117，21： | 1 |
| 16 | A novel extraction-based procedure for the determination of trace elements in estuarine sediment samples by ICP-MS显示文摘 | Morgana Frena Daiane P C Quadros Ivan N B Castilhoa | 2014 | Microchemical Journal2014，117，5： | 1 |
| 17 | Resources distribution approaches in spectrum sharing systems 显示文摘 | Takefumi Y Dennis B Ivan C | 2008 | EURASIP Journal on Wireless Communications and Networking2008，2008，： | 1 |
| 18 | LPR: ACT and MR-compatible puncture robot to enhance accuracy and safety of image-guided Intercentions显示文摘 | Nabil Z Ivan B C' eline F | 2008 | IEEE/ASME Transactions on Mechatronics2008，13，3： | 1 |
| 19 | Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity 显示文摘 | Robert D C Ivan B David J C | 2008 | Aging cell2008，7，3： | 1 |
| 20 | Formation of gold branched plates in diluted solutions of poly(polylpyrrolidone) and their use for the fabricalion of near-infrared absorbing films and coatings显示文摘 | Ivan P B Hoppe C E Yolanda P R | 2008 | Langmuir2008，24，： | 1 |
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