|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters显示文摘AIM: To investigate the effects of ursodeoxycholic acid (UDCA) on chenodeoxycholic acid (CDCA)-induced liver injury in hamsters, and to elucidate a correlation between liver injury and bile acid profiles in the liver. METHODS: Liver injury was induced in hamsters by administration of 0.5% (w/w) CDCA in their feed for 7 d. UDCA (50 mg/kg and 150 mg/kg) was administered for the last 3 d of the experiment. RESULTS: At the end of the experiment, serum alanine aminotransferase (ALT) increased more than 10 times and the presence of liver injury was confirmed histologically. Marked increase in bile acids was observed in the liver. The amount of total bile acids increased approximately three-fold and was accompanied by the increase in hydrophobic bile acids, CDCA and lithocholic acid (LCA). UDCA (50 mg/kg and 150 mg/kg) improved liver histology, with a significant decrease (679.3 ± 77.5 U/L vs 333.6 ± 50.4 U/L and 254.3 ± 35.5 U/ L, respectively, P < 0.01) in serum ALT level. UDCA decreased the concentrations of the hydrophobic bile acids, and as a result, a decrease in the total bile acid level in the liver was achieved. CONCLUSION: The results show that UDCA improves oral CDCA-induced liver damage in hamsters. The protective effects of UDCA appear to result from a decrease in the concentration of hydrophobic bile acids, CDCA and LCA, which accumulate and show the cytotoxicity in the liver. | Tomomichi Iwaki Kaoru Ishizaki Shuji Kinoshita Hideki Tanaka Atsushi Fukunari Makoto Tsurufuji Teruaki Imada | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy显示文摘AIM: To clarify clinical features of the NSAID-induced small bowel lesions using a new method of endoscopy.METHODS: This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at Jichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient.RESULTS: Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively.The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug.CONCLUSION: NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon. | Yoshikazu Hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，31： | 6 |
| 3 | 人工全膝关节中多孔钽金属型和骨水泥型胫骨假体周围骨矿物质密度比较显示文摘背景:多孔钽金属近年来用作全膝关节置换的金属植入材料。其多孔性、低弹性模量和高摩擦性能可保证良好的生理负荷传导并保留假体周围的骨储备。但就我们所知,这种小梁金属(TrabecularMetal)胫骨假体对周围骨矿物质密度的影响未见文献报道。本文的目的是对使用非骨水泥的小梁金属胫骨假体和骨水泥型胫骨假体关节周围骨矿物质密度进行比较。方法:对使用小梁金属胫骨假体和使用骨水泥固定的钴铬钼合金胫骨假体各28个膝分别在术前2周、术后2周、术后6、12、18和24个月进行双能x线吸收光谱扫描,以评价假体周围骨矿物质密度。所有手术均由一名医师操作并采用髌旁内侧入路。结果:术前两组股骨颈、腕关节、腰椎椎体或膝关节的骨密度均无明显差异。术后两组的胫骨骨密度均下降。但术后24个月的胫骨侧位x线片显示小梁金属胫骨假体周围的骨密度减低明显小于骨水泥型胫骨假体组(平均值±标准差,-6.7%±22.9%与-36.8%+24.2%;p=0.002)。两组患者的膝关节学会(Knee Society)评分、膝关节活动度和腰椎椎体骨密度在术后24个月无明显差异。假体微动和假体周围骨折在两组膝关节中均未见到。结论:全膝关节置换术使用小梁金属胫骨假体的胫骨外侧平台的骨密度降低小于使用骨水泥型胫骨假体的膝关节。确定多孔钽金属胫骨假体用于全膝关节置换的长期临床疗效尚待进一步研究。 | Yukihide Minoda Akio Kobayashi Hiroyoshi Iwaki Mitsuhiko Ikebuchi Fumiaki Inori Kunio Takaoka 赵建宁(译) 包倪荣(译) | 2010 | 中华骨科杂志2010，30，6： | 4 |
| 4 | Air-metal hydride battery construction and evaluation 显示文摘 | SAKAI T IWAKI T YE Z | 1995 | J Electrochem Soc1995，142，12： | 2 |
| 5 | 布洛芬葡萄糖醛酸结合物的立体选择性胆排泄及其机制研究(英文)显示文摘目的:为阐明药物转运体在布洛芬(IB)葡萄糖醛酸结合物(IBG)胆排泄中的作用,对IB和IBG在先天性高胆红素血症大鼠(EHBR)和正常SD大鼠(SDR)的胆排泄和血药浓度差异进行了研究。方法:按20 mg/kg剂量静脉注射IB消旋体后,以HPLC法测定了血和胆汁中IB与IBG的浓度。结果:结果表明IBG的胆排泄在EHBR受到了明显抑制,其S-型和R-型IBG的6小时胆排泄量分别为给药量的1.7 %±1.0 %和0.6 %±0.9 %,而在SDR,该值分别为18.4 %±4.0 %和3.0 %±2.4 %。这些结果同时显示了S-型IBG在两种大鼠的胆排泄量均较R-型IBG大,说明该过程存在明显的立体选择性。由于IBG在EHBR的胆排泄受到抑制,其血中的浓度较高。结论:EHBR是一种先天性多药耐药相关蛋白(Mrp2)缺失的大鼠,可以推测布洛芬葡萄糖醛酸结合物的胆排泄过程主要是由Mrp2介导。但由于IBG在EHBR仍有少量胆排泄,故不排除其它转运体参与该过程的可能性。 | CHEN Xi-jing Masahiro Iwaki | 2007 | 中国临床药理学与治疗学2007，12，10： | 2 |
| 6 | TAGE ( toxic AGEs) theory in diabetic complications显示文摘 | Sato T Iwaki M Shimogaito N | 2006 | Curr Mol Med2006，6，3： | 1 |
| 7 | Vibrational energy redistribution in polyatomic liquids:Ultrafast IR-Roman spectroscopy of acetonitrile显示文摘 | Deak J C Iwaki L K Dlott D D | 1998 | Journal of Physical Chemistry A1998，102，： | 1 |
| 8 | TAGE ( toxic AGEs ) theory in diabetic complications 显示文摘 | Sato T Iwaki M Shimogaito N | 2006 | C urr Mol Med2006，6，3： | 1 |
| 9 | Study on the gasification of wastepaper/carbon dioxide catalyzed by molten carbonate salts显示文摘 | Gong Jin Hiroyuki Iwaki Norio Arai | 2005 | Energy2005，30，： | 1 |
| 10 | Multiple functions 'of ergosterol in the fission yeast Schizosaccharomyces pombe 显示文摘 | Iwaki T Lefuji I4 Hiraga Y | 2008 | Microbiology2008，154，3： | 1 |
| 11 | Effects of the fattening peri odon the fatty acid composition of fat deposits and free a- mino acid and inosinic acid contents of the longissimus muscle in carcasses of Japanese Black steers显示文摘 | Iwamoto E Oka A Iwaki F | 2009 | Animal Science Journal2009，80，4： | 1 |
| 12 | A study on the applicability of vibration in fresh high fluidity concrete显示文摘 | Mohanmmad Ihrahim Safawi Ichrio Iwaki Takashi Miura | 2004 | Coment and Concrete Re- search2004，35，9： | 1 |
| 13 | Control of hydrogen equilibrium pressure for C14-type Laves phase aloys 显示文摘 | Gamo T Iwaki T | 1991 | Less-Common Metal1991，17，2174： | 1 |
| 14 | Vibrational energy redistribution in polyatomic liquids:Ultrafast IR-Raman spectroscopy of nitromethane显示文摘 | Deak J C Iwaki L K Diott D D | 1999 | Journal of Physical Chemistry A1999，103，： | 1 |
| 15 | Polyethylene wear particles in synovial fluid after total knee arthroplasty显示文摘 | Minoda Y Kobayashi A Iwaki H | 2003 | Clin Orthop Relat Res2003，，410： | 1 |
| 16 | Vibrational energy redistribution in liquid benzene显示文摘 | Iwaki L K Desk J C Rhea S T Dlott D D | 1999 | Chemical Physics Letters1999，303，： | 1 |
| 17 | X-ray photoelectron spectroscopy studies of high-dose nitrogen ion implanted-chromium:a possibility of a standard material for chemical state analysis显示文摘 | Nishimura O Yabe K Iwaki M | 1989 | Journal of Electron Spectroscopy and Related Phenomena1989，49，3： | 1 |
| 18 | Induction of adiponectin,a fat-derived antidiabetic and antiatherogenic factor,by nuclear receptors显示文摘 | Iwaki M Matsuda M Maeda N | 2003 | Diabetes2003，52，： | 1 |
| 19 | Cutting needle biopsy combined with immunohistochemical study of myeloperoxidase for the diagnosis of histiocytic necrotizing lymphadenitis显示文摘 | Hiroyuki Hanakawa Yorihisa Orita Yasuharu Sato Mai Takeuchi Kyotaro Ohno Noriko Iwaki Toshihiro Ito Kazunori Nishizaki Tadashi Yoshino | 2013 | Acta Oto-Laryngologica2013，，12： | 1 |
| 20 | Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities,and its comparison with azole amifungal drugs显示文摘 | Sakaeda T Iwaki K Kakumoto M | 2005 | J Pharm Pharmacol2005，57，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员