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| 1 | Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis显示文摘Hepatocellular carcinoma(HCC)has emerged as one of the most commonly diagnosed forms of human cancer;yet,the mechanisms underlying HCC progression remain unclear.Unlike other cancers,systematic chemotherapy is not effective for HCC patients,while surgical resection and liver transplantation are the most viable treatment options.Thus,identifying factors or pathways that suppress HCC progression would be crucial for advancing treatment strategies for HCC.The murine double minute 2(MDM2)-p53 pathway is impaired in most of the cancer types,including HCC,and MDM2 is overexpressed in approximately 30%of HCC.Overexpression of MDM2 is reported to be well correlated with metastasis,drug resistance,and poor prognosis of multiple cancer types,including HCC.Importantly,these correlations are observed even when p53 is mutated.Indeed,p53-independent functions of overexpressed MDM2 in cancer progression have been suitably demonstrated.In this review article,we summarize potential effectors of MDM2 that promote or suppress cancer metastasis and specifically discuss the p53-independent roles of MDM2 in liver cancer metastasis from clinical as well as biological perspectives. | Atul Ranjan Kaustav Bera Tomoo Iwakuma | 2016 | Hepatoma Research2016，2，1： | 2 |
| 2 | MDM2 binding protein,a novel metastasis suppressor显示文摘 | Iwakuma T Agarwal N | | 0，，3： | 1 |
| 3 | Magnetic field angular dependence of AC losses in bi-2223 superconducting wires显示文摘 | Yuzo Fukuda Masamichi Fukui | 2003 | Physiea C Su-percon and its Appl2003，，420： | 1 |
| 4 | Dependence of the autumn emergence of Tokunagayusurikd akamusi (Diptera: Chironomidae) on water temperature显示文摘 | Iwakuma T S Yasuno M | 1989 | Jpn J Limnol1989，50，： | 1 |
| 5 | Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function 显示文摘 | Cui Y Iwakuma T Chang LJ | 1999 | J Virol1999，73，8： | 1 |
| 6 | Synthesis and thromboxane A 2 antagonistic activity of indane derivatives 显示文摘 | Shinozaki K Sato H Iwakuma T | 1999 | Bioorg Med Chem1999，9，： | 1 |
| 7 | Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome显示文摘 | Lang GA Iwakuma T Suh YA | 2004 | Cell2004，119，6： | 1 |
| 8 | Gain of function of a p53 hot spot mutation in a mouse model of Li-Franmeni syndrome 显示文摘 | Lang GA Iwakuma T Suh YA | 2004 | Cell2004，119，6： | 1 |
| 9 | Gain of func- tion of a P53 hot spot mutation in a mouse model of Li- Fraumeni syndrome 显示文摘 | LANG G A IWAKUMA T SUH Y A | 2004 | Cell2004，119，6： | 1 |
| 10 | Sodium acyloxyboro- hydride as new reducing agents:I reduction of carbox- amides to the corresponding amines 显示文摘 | Umino N Iwakuma T Itoh N | 1976 | Tetrahedron Lett1976，17，10： | 1 |
| 11 | Develop- ment of a 500 kVA-class oxide-superconducting power trans- former operated at liquid-nitrogen temperature 显示文摘 | FUNAKI K IWAKUMA M KAJIKAWA K | 1998 | Cryogenics1998，38，2： | 1 |
| 12 | P, esidual pesticides and theirtoxicity to flesh- water shrimp in the littoral and pelagiczones of Lake Kasumigaura, Japan显示文摘 | Nohara S Iwakuma T | 1996 | Chemosphere1996，33，7： | 1 |
| 13 | Organization and expression of the mouse gene for DNA repair methyltransferase显示文摘 | Iwakuma T Shirasishi A Fukuhara M | 1996 | DNA Cell Biol1996，15，： | 1 |
| 14 | Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function显示文摘 | Cui Y Iwakuma T Chang LJ | 1999 | J Virol1999，73，： | 1 |
| 15 | The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss显示文摘 | Terzian T Suh YA Iwakuma T | 2008 | Genes and Development2008，22，9： | 1 |
| 16 | Treatment outcome inpatients with stage IH breast cancer treated with neoadjuvantchemotherapy显示文摘 | Takahashi R Toh U Iwakuma N | 2013 | Exp Ther Med2013，6，5： | 1 |
| 17 | MDM2,an introduction显示文摘 | Iwakuma T Lozano G | 2003 | Mol Cancer Res2003，1，14： | 1 |
| 18 | Self-inactivating lentiviral vectors with U3 and U5 modifications显示文摘 | Iwakuma T Cui Y Chang LJ | 1999 | Virology1999，261，1： | 1 |
| 19 | Nav- igation surgery for intraoperative sentinel lymph node detection using Indocyanine green(ICG) fluorescence real-time imaging in breast cancer 显示文摘 | Toh U Iwakuma N Mishima M | 2015 | Breast Cancer Res treat2015，153，2： | 1 |
| 20 | Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system显示文摘 | Chang LJ Urlacher V Iwakuma T Cui Y Zucali J | | 0，，05： | 1 |
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