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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Non-inva- sive brain-actuated wheelchair based on a P300 neurophysio- logical protocol and automated navigation 显示文摘 | ITURRATE I ANTELIS J MINGUEZ J | 2009 | IEEE transac- tions on Robotics2009，25，3： | 1 |
| 4 | Buckling strength of multi-story sway, non-sway and partially-sway frames with semi-rigid connections 显示文摘 | MAGEIROU G E ( -ANTES C J | 2006 | Journal of Constructional Steel Research2006，62，9： | 1 |
| 5 | Serum immunoglobulin G antibody to Porphyromonas gingivalis in rapidly progressive periodontitis:titer,avidity,and subclass distribution显示文摘 | Whitney C Ant J Monela B | 1992 | Infect Immun1992，60，6： | 1 |
| 6 | Chemical and kinetics of chemical vapor deposition of pyrocarbon-V-Confirma-tion of the influence of the substrate surface area/reactor volume ratio显示文摘 | J Antes Z Hu W Zhang | 1999 | Carbon1999，37，12： | 1 |
| 7 | Monofunctional epoxy - POSS dispersed in epoxy - a- mine networks : Effect of a prereaction on the morphology and crystallinity of POSS domains 显示文摘 | ZUCCHI I A GAL - ANT M J WILLIAMS R J J | 2007 | Macromolecules2007，40，： | 1 |
| 8 | An optimization of the Wa-telowscore using regression and artificial neural net works显示文摘 | Ant hony D Clark M Darllender J | 2004 | Cline Rehabil2004，14，1： | 1 |
| 9 | Immediate allergic reactions by polyethylene glycol 4000:two cases显示文摘 | Ant o n Giron e s M Roan Roan J de la Hoz B | 2008 | Allergol lmmunopathol (Madr)2008，36，2： | 1 |
| 10 | Theoretical analysis of stone sawing with diamonds显示文摘 | KONST ANT Y J | 2002 | Journal of Materials Processing Technolo-gy2002，123，1： | 1 |
| 11 | Antimicrobial and safety aspects and biotechnological potential of bacteriocinogenic enterococci isolated from mallard ducks Anas plat yrhynchos显示文摘 | S6NCHEZ J BAS ANT AA GMEZ- SALA B | 2007 | Int J Food Microbiol2007，1173，： | 1 |
| 12 | Effect of adjuvant chemoradiotherapy on overall survival of gastric cancer patients submitted to D2 lymphadenectomy显示文摘 | Alexandre A. A. Jácome Durval R. Wohnrath Cristovam Scapulatempo Neto José Humberto T. G. Fregnani Ana Luiza Quinto Ant?nio T. T. Oliveira Vinícius L. Vazquez Gilberto Fava Edson Z. Martinez José S. Santos | 2013 | Gastric Cancer2013，，2： | 1 |
| 13 | Management of congenital tracheal stenosis in infancy 显示文摘 | Antón - Pacheo JL Cano I Comas J | 2006 | Eur J Cardiothorac Surg2006，29，6： | 1 |
| 14 | Fluoride Deter mination in Carbon Nanotubes by Ion Selective Electrode 显示文摘 | Antes F G Pereira J S F Spadoa LC | 2012 | Journal of The Brazilian Chemical Society2012，23，6： | 1 |
| 15 | A controlled trial of noninvasive ventilation for chronic obstructive pulmonary disease exacerbations显示文摘 | CARRERA M MARN J M ANTN A | 2009 | J Crit Care2009，24，3： | 1 |
| 16 | Dissolution ofparticles of pyrite mineral by direct attachment ofThiobacillus ferrooxidans 显示文摘 | Shrihari J Jay ant M Kumar R | 1995 | Hydrometallurgy1995，38，2： | 1 |
| 17 | Statistical approach to mechanical behavior of ceramic matrix composites based on Portland clinker显示文摘 | Antón N Velasco F Gordo E Torralba J M | 2001 | Ceramics International2001，27，4： | 1 |
| 18 | Detection of hypervascular nodular hepatocel- lur carcinomas : value of triphasic helical CT compared with iodized oil CT 显示文摘 | CHOI BI LEE H J H ANT JK | 2010 | AJR2010，157，2： | 1 |
| 19 | Regulation of apoptosis bytypelll interferons显示文摘 | Li W Lewis - Antes A Huang J | 2008 | Cell Prolif2008，41，6： | 1 |
| 20 | The relationship between capsid protein(VP2) sequence and pathogenicity of Aleutian mink disease parvovims(ADV): apossible role for raccoons in the transmission of ADV infovfioos显示文摘 | Oie K L Dun'ant G Wolfinbarger J B | 1996 | J Virol1996，70，2： | 1 |
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