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| 1 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 2 | Stabilization of erythrocyte membranes by polyamines显示文摘 | Mohandas N Marton L J | 1983 | Pro Nat Acad Sci1983，80，： | 1 |
| 3 | Dietary self-efficacy:Determinant of compliance behaviors and biochemical outcomes in hemodialysis patients显示文摘 | Zrinyi M Juhasz M Balla J | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
| 4 | Diagnosis of goose circovirus infection in Hungarian geese samples using poly- merase chain reaction and dot blot hybridization tests 显示文摘 | Balla N W Smyth J A Weston J H | 2004 | Avian Pathol2004，33，1： | 1 |
| 5 | Multiple sclerosis and autoimmune diseases 显示文摘 | BAKER H W BALLA J I MACKAY I R | 1972 | Aus N Z J Med1972，2，： | 1 |
| 6 | Induction of heme oxygenase in toxic renal injury: a protective role in cisplatin nephrotoxicity in the rat 显示文摘 | Agarwal A Balla J Alam J | 1995 | Kidney Int1995，48，： | 1 |
| 7 | Commonly missed orthopedic problems显示文摘 | Ballas MT Tytko J Mannarino F | 1998 | Am Fam Physician1998，57，2： | 1 |
| 8 | Early - onset carotid atherosclerosis is assocaited with increased intima - media thickness and elevated serum levels of inflammatory markers 显示文摘 | Magyar MT Szikszai Z Balla J | 2003 | Stroke2003，34，1： | 1 |
| 9 | Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?显示文摘Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease. | Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus | 2014 | World Journal of Clinical Cases2014，2，12： | 1 |
| 10 | Serum levels of platelet released CIM0 ligand are increased in early onset occlusive carotid artery disease 显示文摘 | Balla J Magyar MT Bereezki D | 2006 | Dis Markers2006，22，3： | 1 |
| 11 | Ziprasldone: a novel psyehotropic with unique properties 显示文摘 | Goodniek J Ballas P | 2004 | Expert Rev Nexerother2004，14，： | 1 |
| 12 | Red blood cell,hemoglobin and heme in the progression of atherusclerosis 显示文摘 | Jeney V Balla G Balla J | 2014 | Front Physio12014，5，： | 1 |
| 13 | Seasonal variation in the macroinvertebrate fauna of wetlands of differing water regime and nutrient status on the Swan Coastal Plaino,Westem Australia显示文摘 | Balla S A Davis J A | 1995 | Hydrobiologia1995，299，： | 1 |
| 14 | Is more ever too much:the number of indicators per factor in confirmatory factor analysis显示文摘 | Marsh H W Han K T Balla J R Grayson | 1998 | Multivariate Behavioral Research1998，33，2： | 1 |
| 15 | Structure-Stability Study of Cyclodextrin Complexes with Selected Vola- tile Hydrocarbon Contaminants of Soils显示文摘 | N Szaniszl6 E Fenyvesi J Balla | 2005 | Journal of Inclusion Phenomena and Macrocyclic Chemistry2005，53，34： | 1 |
| 16 | Serum levels of platelet released CD40 ligand are increased in early onset occlusive carotid artery disease 显示文摘 | Balla J Magyar MT Bereczki D | 2006 | Dis Markers2006，22，3： | 1 |
| 17 | Ferritin:a cytoprotective antioxidant stratagem of endothelium 显示文摘 | Balla G Jacob HS Balla J Rosenberg M Nath K Apple F | 1992 | J Biol Chem1992，257，18： | 1 |
| 18 | Once-monthly subcutaneous CERA maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly 显示文摘 | Sulowicz W Locatelli F Ryckelynck JP Balla J Csiky B Harris K | 2007 | Clin J Am Soc Nephrol2007，2，4： | 1 |
| 19 | Competitive canalization of PIN-dependent auxin flow from axillary buds controls pea bud outgrowth显示文摘 | Balla J Kalousek P Reinohl V Friml J Procházka S | 2011 | Plant Journal2011，65，4： | 1 |
| 20 | Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants显示文摘 | Sato K Balla J Otterbein L | 2001 | J Immunol2001，166，6： | 1 |
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