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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 3 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 4 | Two new male contra-ceptives exert their effects by depleting germ cells prema-turely from the testis显示文摘 | Cheng CY Silvestrini B Grima J | 2001 | Biol Reprod2001，65，2： | 1 |
| 5 | Outcome of Pulmonary Multidrug-Resistant Tuberculosis: a 6-yr Follow-up Study显示文摘 | Chiang CY Enarson DA Yu MC Bai KJ Huang RM Hsu CJ Suo J Lin TP | 2006 | Eur Respir J2006，28，5： | 1 |
| 6 | Efficacy of steroid injection on idiopathic sud-den sensofineural hearing loss 显示文摘 | Roebuck J Chang CY | 2006 | Otolaryngol Head Neck Surg2006，135，2： | 1 |
| 7 | The roles of Kruppel-like factor6and peroxisome proliferator-activated receptor-gamma in theregulation of macrophage inflammatory protein-3alpha at earlyonset of diabetes显示文摘 | Qi W Holian J Tan CY | 2011 | Int J Biochem Cell Biol2011，43，3： | 1 |
| 8 | Immunoidentification of gonadotropin releasing hormone receptor in human sperm, pituitary and cancer cells显示文摘 | Lee CY Ho J Chow SN | 2000 | Am J Reprod Immunol2000，44，3： | 1 |
| 9 | Perceptual differences between stroke patients with cerebral infraction and intracerebral hemorrhage显示文摘 | Su CY Chang J J Chen HM | 2000 | Arch Phys Rehabil2000，81，： | 1 |
| 10 | Absence of excitotoxicity - induced apoptosis in the hippocampus of mice lacking the Jnk3 gene 显示文摘 | Yang DD Kuan CY Whitmarsh A J | 1997 | Nature1997，389，6653： | 1 |
| 11 | Characteristics and outcome for very elderly patients (≥ 80 years) admitted to a respiratory care center in Taiwan显示文摘 | Su J Lin CY Chen SK | | 0，，： | 1 |
| 12 | Evaluation of Physical Capture Efficiency and Disinfection Capability of an lodinated Biocidal Filter Medium显示文摘 | Shumate SR Wu CY wander J | | 0，，01： | 1 |
| 13 | Extent of surgery affects survival for papillary thyroid cancer显示文摘 | Bilimoria KY Bentrem D J Ko CY | 2007 | Ann Surg2007，246，3： | 1 |
| 14 | Point mutation in Pompe dis- ease in Chinese显示文摘 | Shieh J J Wang LY Lin CY | 1994 | J Inherit Metab Dis1994，17，1： | 1 |
| 15 | A novel deletion mutation of the EXT2 gene in a large Chinese pedigree with herediary mutiple exostosis显示文摘 | Xiao CY Wang J Zhang SZ | 2001 | Br J Cancer2001，85，2： | 1 |
| 16 | Survival of the fittest? Entrepreneurial human capital and the persistence of underperforming firms 显示文摘 | Gimeno J TB Folta AC Cooper and CY Woo | 1997 | Administrative Science Quarterly1997，，42： | 1 |
| 17 | Sessle,Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn显示文摘 | Chiang CY Wang J Xie YF | 2007 | J Neurosci2007，27，34： | 1 |
| 18 | Vibrio vulnificus in Taiwan 显示文摘 | Hsueh PR Lin CY Tang H J | 2004 | Emerg Infect Dis2004，10，8： | 1 |
| 19 | Genotyping of B and non-B subtypes of human immunodeficiency virus type 1显示文摘 | Tong CY Mullen J Kulasegaram R | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 20 | The A21M polymorphism in CYP7A1 gene affects its promoter activity 显示文摘 | Chen Y J Zhang SZ Xiao CY | 2006 | Chi j Biochem Mol Biol2006，22，： | 1 |
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