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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 3 | Differential expression and function of Arabidopsis thaliana NHX Na^+/H^+ antiporters in the salt stress response显示文摘 | Yokoi1 S Francisco J Q Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 4 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains 显示文摘 | Rodriguez-Hemandcz M J Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 5 | Genetic relationship amongworldwide strains of Xanthomonas causing canker in citrus spicies and design of new primers for their idetification by PCR显示文摘 | Cubero J Graham J H | 2002 | Appl Environ Microbiol2002，，68： | 1 |
| 6 | TBAR: An efficient method for association rule mining in relational databases显示文摘 | F Berzal J Cubero N Matin | 2001 | Data anti Knowl- edge Engineering2001，37，1： | 1 |
| 7 | Prediction of infarction related artery occlusion and multivessel disease in postinfarction anggina显示文摘 | Valenzuela LF Cubero J Cruz-Fernandez JM | 2007 | Int J Cardio2007，115，3： | 1 |
| 8 | Crystal structure of low magnesium-content alite: Application to Rietveld quantitative phase analysis 显示文摘 | DELATORRE A G DEVERA R N CUBEROS A J M | 2008 | Cem Concr Res2008，38，11： | 1 |
| 9 | Deve- lopment of a Machine for the Automatic Sorting of Pome- granate( Punica Granatum)Arils Based on Computer Vision 显示文摘 | BLASCO J CUBERO S G6MEZ-SANCHIS J | 2009 | Journal of Food Engineering2009，90，1： | 1 |
| 10 | TBAR:an efficient method for association rule mining in relational databases显示文摘 | Berzal F do Cubero J C Marin N | 2001 | Data & Knowledge Engineering2001，37，： | 1 |
| 11 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response显示文摘 | Yokoi S Francisco J Q Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 12 | Aluminum-rich Belite Sulfoaluminate Cements:Clinkering and Early Age Hydration显示文摘 | Carmen Martín-Sedeio M Antonio J M Cuberos | | 0，，： | 1 |
| 13 | Phylogenetic analysis in genus Cicer and cultivated chickpea using RAPD and ISSR markers显示文摘 | Iruela M Rubio J Cubero JI | 2002 | Theor Appl Genet2002，104，： | 1 |
| 14 | TBAR: An efficient method for association rule mining in relational databases显示文摘 | BERZAL F CUBERO J MARIN N | 2001 | Data and Knowledge Engineering2001，37，1： | 1 |
| 15 | Transient apical ballooning syn-drome:a transition towards adulthood显示文摘 | Segovia Cubero J Peraira Moral R | | 0，，： | 1 |
| 16 | 查看详情显示文摘 | Hobza P Sponer J Cubero E Orozco M. Luque F.J | | 0，，： | 1 |
| 17 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+antiporters in the salt stress response显示文摘 | Yokoi S Quintero F J Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 18 | ART: A hybrid classification model 显示文摘 | F Berzal J C Cubero D Sanchez J M Serrano | 2004 | Machine Learning (S0885-6125)2004，54，1： | 1 |
| 19 | Ameva:an autonomous discretization algorithm 显示文摘 | GONZALEZ A L CUBEROS F J VELASCO F | 2008 | Expert Systems with Applications2008，36，3： | 1 |
| 20 | TBAR: an effi- cient method for association rule mining in relation- al databases显示文摘 | BERZAL F CUBERO J MAR I N | 2001 | Data and Knowledge Engineering2001，37，1： | 1 |
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