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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | The cryogenic nitrogen automotive engine 显示文摘 | Dooley J Hammond R P | 1984 | Mechanical Engineering1984，，： | 1 |
| 4 | Advances in methods for the production, purification, and characterization of HIV-1 Gag-Env pseudovirion vaccines显示文摘 | Hammonds J Chen X Zhang X | 2007 | Vaccine2007，，： | 1 |
| 5 | A Semiconducting Metal-Oxide Array for Monitoring Fish Freshness显示文摘 | Hammond J Marquis B B Michaels R et a1 | 2002 | Sensors and Actuators B2002，，84： | 1 |
| 6 | Purine and pyrimidine metabolism in the Trypansosmatidae显示文摘 | Hammond D J Gutteridge W E | 1984 | Mol Biochem Parasitol1984，13，： | 1 |
| 7 | Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit mode 显示文摘 | Muhlestein J B Anderson J L Hammond E H | 1998 | Circulation1998，97，： | 1 |
| 8 | The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation 显示文摘 | Ferro V Hammond E Fairweather J K | 2004 | Mini Rev Med Chem2004，4，6： | 1 |
| 9 | Higher - order spectra: the bispectrum and trispeetrum 显示文摘 | COLLIS W B WHITE P R HAMMOND J K | 1998 | Mechanical System and Signal Processing1998，12，3： | 1 |
| 10 | The analysis of non-stationary signals using time-frequency methods 显示文摘 | Hammond J K White P R | 1996 | Journal of Sound and Vibration1996，190，3： | 1 |
| 11 | Retrograde menstruation in healthy women and in patients with endometriosis显示文摘 | Halme J Hammond MG Hulka JF | | 0，，02： | 1 |
| 12 | American Socie- ty o Clinical Oncology / College o显示文摘 | Wolff A C Hammond M E Schwartz J N | 2007 | Arch Pathol Lab Med2007，131，1： | 1 |
| 13 | Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain显示文摘 | Fitzgerald D P Cole S J Hammond A | 2006 | Neuroscience2006，142，3： | 1 |
| 14 | 显示文摘 | Hammond P J Bell A P Hall C D | 1983 | J Chem Soc Perkin Trans 11983，，4： | 1 |
| 15 | Expression of the rabies virus glycoprotein in transgenic tomatos 显示文摘 | McGarvey P B Hammond J Dienelt M M | 1995 | Bio/Tech-nology1995，13，： | 1 |
| 16 | Tracking Spore-Forming Bacterial Contaminants in Fluid Milk-Processing Sys- tems 显示文摘 | HUCK J R HAMMOND B H MURPHY S C | 2007 | Journal of Dairy Science2007，90，： | 1 |
| 17 | Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: a systematic review显示文摘 | YOO J LACCHETTI C HAMMOND J A | 2014 | Head Neck2014，36，： | 1 |
| 18 | How do plants respond to nutrient shortage by biomass allocation?显示文摘 | Hermans C Hammond J P White P J | 2006 | Trends in Plant Science2006，11，12： | 1 |
| 19 | Global FMD control-Is it an option? 显示文摘 | Kitching P Hammond J Jeggo M | 2007 | Vaccine2007，25，1： | 1 |
| 20 | The World Trade Center Attack Helping the Helpers: the Role of Critical Incident Stress Management显示文摘 | Hammond J Brooks J | 2001 | Critical Care2001，5，： | 1 |
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