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| 1 | Clinical epidemiology and disease burden of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis. | Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed | 2017 | World Journal of Gastroenterology2017，23，47： | 70 |
| 2 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 3 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 4 | Microstructual,electrical properties and temperature stability of resonant frequency in Pb(Ni1/2W1/2)O3-Pb(Mn1/3Nb2/3)O3-Pb(Zr,Ti)O3 ceramics for high-power piezoelectric tranformer显示文摘 | Yoo J H Lee Y W Yoon K H | 2001 | Jpn J Appl Phy Part12001，40，5： | 2 |
| 5 | Decellularization for whole organ bioengineering显示文摘 | J E Arenas-Herrera I K Ko A Atala J J Yoo | 2013 | Biomedical Materials2013，，1： | 2 |
| 6 | Buckling,post-buckling and crippling of shallow curved composite plates with edge stiffeners显示文摘 | Arnold R R Yoo S Y Mayers J | 1985 | AIAA1985，23，5： | 2 |
| 7 | Methods of Operative Fixation of the Acromio-Clavicular Joint: A Biomechanical Comparison显示文摘 | Alison J McConnell Daniel J Yoo Rad Zdero Emil H Schemitsch Michael D McKee | 2007 | Journal of Orthopaedic Trauma2007，，4： | 2 |
| 8 | Hepatoid adenocarcinoma of the transverse colon显示文摘 | Jan Slotta Bernd Jüngling Yoo Kim Mathias Wagner Dorian Igna Martin Schilling | 2012 | International Journal of Colorectal Disease2012，，7： | 2 |
| 9 | Fingerprint-based remote user authentication scheme using smart cards显示文摘 | LEE J K RYU S R YOO K Y | | 0，，12： | 2 |
| 10 | Effect of cervical spine motion on neuroforamina dismensions显示文摘 | Yoo Yu Bayley J Zou D | 1992 | Spine1992，17，： | 2 |
| 11 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 12 | Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies 显示文摘 | Ambati J Ambati B K Yoo S H | 2003 | Surv Ophthalmol2003，48，3： | 1 |
| 13 | Salt tolerance study in Zoysiagrass显示文摘 | Lee G J Yoo Y K Kim K S | 1994 | Horticulture Science1994，35，3： | 1 |
| 14 | Identification of rat mammary tumor - 1 gene ( RMT - 1 ) , which is highly expressed in rat mammary tumors 显示文摘 | Chiou S Yoo J Loh KC | 2001 | Cancer Dett2001，174，3： | 1 |
| 15 | The Impact of Marketing - induced Versus Word - of - mouth Customer Acquisition on Customer Equity Growth 显示文摘 | Villanueva J Yoo S Hanssens D M | 2008 | Journal of Marketing Research2008，45，1： | 1 |
| 16 | P-glycoprotein-mediated transport of berberine across Caco-2 cellmonolayers 显示文摘 | Maeng H J Yoo H J Kim I W | 2002 | J Pharm Sci2002，91，12： | 1 |
| 17 | An Ellipse Detection Method from the Polar and Pole Definition of Conics显示文摘 | Yoo J H Sethi I K | 1993 | Pattern Recognition1993，26，2： | 1 |
| 18 | Activa- tion of EphB2 and its ligands promotes vascular smooth muscle cell proliferation 显示文摘 | WOODS T C BLYSTONE C R YOO J | 2002 | J Biol Chem2002，277，3： | 1 |
| 19 | Design and operation consid-erations for wastewater treatment of municipal wastewater显示文摘 | Shim J K Yoo I K Lee Y M | 2002 | Water Research2002，36，： | 1 |
| 20 | Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid显示文摘 | KIM J H YOO S J OH D K | 1996 | Enzyme Microb Tech1996，19，6： | 1 |
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