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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 3 | Silica-volatile interaction and the geological cause of the Xuan Wei lung cancer epidemic显示文摘 | Large D J Baruchspiro S K Tian L W | 2009 | Environmental Science and Technology2009，43，： | 1 |
| 4 | Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4, 5-bisphosphate and protein kinase C in vascular smooth muscle 显示文摘 | Shi J Birnhaumer L Large WA | 2014 | The FASEB Journal2014，28，1： | 1 |
| 5 | Biases and heuristics in Difference between entrepreneurs organizations 显示文摘 | Busenitz L W Barney strategic decision-making : and managers in large Business venturing 1997 J B | 1997 | Journal of1997，12，1： | 1 |
| 6 | Littering in context:Personal and environmental predictors of littering behavior显示文摘 | Schultz P W Bator R Tabanico J Bruni C Large L B | 2013 | Environment and Behavior2013，45，： | 1 |
| 7 | Gender differences in collaborative Web searching behavior:an elementary school study显示文摘 | Large A L Beheshti J Rahman T | 2002 | Information Processing and Management2002，38，3： | 1 |
| 8 | Sediment-hosted 显示文摘 | Leach D L Sangster D F Kelley K D Large R R Garven G Al- len C R Gatzmer J and Wallters S | 2005 | Economic Geology 100th An- niversary Volume2005，，： | 1 |
| 9 | High dynamic range characterization of the trauma patient plasma proteome显示文摘 | Liu T Qian W J Gritsenko M A Xiao W Moldawer L L Kaushal A Monroe M E Vamum S M Moore R J Purvine S O Maier R V Davis R W Tompkins R G Camp D G 2nd Smith R D and the Inflammation and the Host Response to Injury Large Scale Collaborative Research Programm | | 0，，10： | 1 |
| 10 | The alteration box plot: A simple approach to understanding the relationship between alteration mineralogy and lithogeochemistry associated with volcanic-hosted massive sulfide deposits显示文摘 | Large R R Gemmell J B Paulick H Huston D L | 2001 | Econ Geol2001，96，5： | 1 |
| 11 | The role of viscoelastic properties in strain testing using microstructured polymer optical fibres 显示文摘 | LARGE M C J MORAN J YE L | 2009 | Measurement Science and Technology2009，20，3： | 1 |
| 12 | Sediment-hosted lead-zinc deposits: A global perspective显示文摘 | Leach D L Sangster D F Kelley K D Large R R Garven G Allen C R Gutzmer J Waiters S G | 2005 | Econ Geol2005，100，： | 1 |
| 13 | In situ Pb-isotope analysis of pyrite by laser ablation (multi-collector and quadrupole) ICPMS显示文摘 | Woodhead J Hergt J Meffre S Large R R Danyushevsky L Gilbert S | 2009 | Chemical Geology2009，262，： | 1 |
| 14 | Radio transmission to and from underground coal mines-theory and experiment显示文摘 | Large D G Ball L Farstad A J | 1973 | IEEE Transactions on Communication1973，21，3： | 1 |
| 15 | The prandtl number effect on the transition in natural convection along a vertical显示文摘 | A Bejan J L Large | 1990 | Journal of Heat Transfer1990，112，： | 1 |
| 16 | 查看详情显示文摘 | Teo S L Lin V K Marry R Large N Llado E A Arbouet A Gi-rard C Aizpurua J Tripathy S Mlayah A | | 0，，： | 1 |
| 17 | Climate Modeling显示文摘 | DONNER L J LARGE W G | 2008 | Annual Review of En-vironment and Resources2008，33，： | 1 |
| 18 | Sediment-hosted lead-zink deposit: A global perspective显示文摘 | LEACH D L SANGSTER D F KELLEY K D LARGE R R GARVEN G ALLEN C R GATZMER J WALLTERS S | 2005 | Economic Geology 100th Anniversary Volume2005，100，1： | 1 |
| 19 | River and floodplain rehabilitation in Western Europe:Opportunities and constraints显示文摘 | DeWall L C Large A R G Gippel C J | 1995 | Arch Hydrobiol Suppl1995，9，： | 1 |
| 20 | River and flood plain rehabilitation in Western Europe:Opportunities and constraints显示文摘 | De Wall L C Large ARG Gippel C J | | 0，，： | 1 |
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