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	题名	作者	年代	出处	被引量
1	Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease.	Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen	2017	World Journal of Gastroenterology2017，23，26：	8
2	Determination of cytokine responses using a multiplexed fluorescent microsphere immunoassay显示文摘	Martins T B Pasi B M Pickering J W	2002	Am J Clin Pathol2002，118，3：	1
3	Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘	D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey	2012	Lancet Oncology2012，，10：	1
4	The biology and treatment of EML4-ALK non-small cell lung cancer显示文摘	Takaaki Sasaki Scott J. Rodig Lucian R. Chirieac Pasi A. J?nne	2010	European Journal of Cancer2010，，10：	1
5	Epidemiology and pathophysiology of cancerassociated thrombosis显示文摘	S Noble J Pasi	2010	British Journal of Cancer2010，102，：	1
6	A framework for genetic service provision for haemophilia and other inherited bleeding disorders 显示文摘	Ludlam CA Pasi K J Bolton-Maggs P	2005	Haemophilia2005，11，2：	1
7	Fulminant liver failure in association with the emetic toxin of Bacillus cereus显示文摘	MAHLER H PASI A KRAMER J M	1997	N Engl J Med1997，336，：	1
8	Epidemiology and pathophysiology of cancer-associated thrombosis 显示文摘	S Noble J Pasi	2010	British Journal of Cancer2010，13，1021：	1
9	Thrombosis and inflammatory bowel disease显示文摘	Irving PM Pasi K J Rampton DS	2005	Clin Gastroenterol Hepatol2005，3，7：	1
10	Correction of both prothrombin time and primary haemostasis by recombinant factor Ⅶ during therapeutic alcohol inection显示文摘	Papatheodoridis G Chung S Keshav S Pasi J Burroughs AK		0，，：	1
11	Outcome of patients with pulmona- ry carcinoid tumors receiving chemotherapy or chemo - radiotherapy 显示文摘	Lori JW Mark RC Pasi A J	2004	Lung Cancer2004，44，2：	1
12	Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘	D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey	2012	Lancet Oncology2012，，10：	1
13	Epidemiology and pathophysiology of cancer-associated thrombosis显示文摘	Noble S Pasi J	2010	Br J Cancer2010，1021，：	1
14	Cytokines in depression and heart failure显示文摘	Pasie J Levy WC Sullivan MD	2003	Psychosconm Med2003，65，2：	1
15	Determination of cy tokine responses using a multiplexed fluorescent microsphere immunoassay显示文摘	Martins T B Pasi BM Pickering J W	2002	Am J Clin Pathol2002，118，：	1
16	Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘	D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey	2012	Lancet Oncology2012，，10：	1
17	EGFR mutations in lung cancer:Correlation with clinical re- sponse to gefitinib therapy显示文摘	Paez J Guillermo Janne Pasi A Lee Jeffrey C	2014	Science2014，304，5676：	1
18	Management of acquired resistance to epidermal growth factor receptor kinase inhibitors in patients with advanced non‐small cell lung cancer显示文摘	Adrian G. Sacher Pasi A. J?nne Geoffrey R. Oxnard	2014	Cancer2014，，15：	1
19	SILCA-supported ionic liquid catalysts for fine chemicals 显示文摘	MIKKOLA J T VIETANEN PASI P KARHU K K H etal	2007	ApplCatal A: General2007，328，：	1
20	The span length and cross-sectional design affect values of strength显示文摘	Alander Pasi Lassila Lippo V J Vallittu Pekka K	2005	Dental Materials2005，21，：	1

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