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| 1 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 2 | Immuno-oncology combinations: raising the tail of the survival curve显示文摘There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design. | Samuel J. Harris Jessica Brown Juanita Lopez Timothy A. Yap | 2016 | Cancer Biology & Medicine2016，13，2： | 6 |
| 3 | 牧草细胞壁:瘤胃内降解(英文)显示文摘牧草细胞壁在瘤胃内降解主要是瘤胃微生物起作用。本综述概略地介绍了牧草细胞壁降解所涉及的以细菌为主的微生物,细胞壁多糖分解所需的酶,细胞壁降解模型以及细胞壁降解的限制因素。 | 孙学钊 Simone O. Hoskin Keith N. Joblin Ian G. Andrew Philip J. Harris 盛亦兵 | 2007 | 草地学报2007，15，4： | 5 |
| 4 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 5 | A Global Perspective on Irritable Bowel Syndrome: A Consensus Statement of the World Gastroenterology Organisation Summit Task Force on Irritable Bowel Syndrome显示文摘 | Eamonn M. M. Quigley Hussein Abdel-Hamid Giovanni Barbara Shobna J. Bhatia Guy Boeckxstaens Roberto De Giorgio Michel Delvaux Douglas A. Drossman Amy E. Foxx-Orenstein Francisco Guarner Kok-Ann Gwee Lucinda A. Harris A. Pali S. Hungin Richard H. Hunt John | 2012 | Journal of Clinical Gastroenterology2012，，5： | 4 |
| 6 | Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits显示文摘分支链氨基酸 transaminases (BCAT ) 在分支链氨基酸白氨酸,异白氨酸,和缬氨酸的新陈代谢有一个关键角色。这些酶催化合成的最后步和这些氨基酸的降级的起始的步。尽管在植物的分叉的链氨基酸的 biosynthetic 小径广泛地被调查了,很多基因被描绘了,他们在植物的分解代谢完全还没被理解。我们以前在西红柿描绘了分叉的链氨基酸 transaminase 基因家庭,揭示 subcellular 本地化和六基因编码的酶的运动性质。这里,我们在水果开发期间检验了酶的可能的功能。我们进一步描绘了在分叉的链氨基酸 transaminases 的表示不同的转基因的植物 1 和 3,在线 overexpressing 任何一个 BCAT1 或 BCAT3 在在 BCAT1 和 volatiles 的层次缺乏的水果评估呼吸的率。我们测试的份量上经由喂实验的先锋和同位素,在水果 volatiles 的形成的分叉的链氨基酸和他们的相应 keto 酸的重要性。我们的结果不仅第一次在水果呼吸表明分叉的链氨基酸的重要性,而且揭示那 keto 酸,而非氨基酸,是为分叉的链风味 volatiles 的可能的先锋。 | Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 4 |
| 7 | A Large Therizinosauroid(Dinosauria:Theropoda) from the Early Cretaceous of Northwestern China显示文摘我们此处描述 theropoddinosaur 的头部的骨骼在 Yujingzi 盆的更低的白垩纪 Xinminpu 组发现了的一根联系部分柱子,在 Gansu 省的 Jiuquanarea,西北的中国。它的肱骨展示,例如强烈扩展了近似、远侧的结束,一个很好发达的中间的有块茎,在肱骨的头部的表面上表示的远侧的髁,和 hypertrophied entepicondyle,决定性地建立标本的 thetherizinosauroid 亲密关系。它在有作为不同于另外的 therizinosauroids 使神圣,有 thedorsomedial 上的突出的圆、有条纹的肿大的糟糕界定的浅窝的窝它的肩胛部分,和耻骨出现与一强烈凹面头部的边缘。Itrepresents 新税在上, Suzhousaurus megatherioides 情报。et sp。nov。是的 Cladistic 分析 recoversSuzhousaurus 姐妹税在上 Nothronychus mckinleyi 从中间 -- 西方的 NorthAmerica 的白垩纪;一起,他们是 Therizinosauroidea 的基础成员,更多比 EarlyCretaceous Falcarius 和 Beipiaosaurus 发源,但是更少与“ Nanshiungosaurus ”比 Alxasaurus 和 Therizinosauridae.Along 发源从在 Mazongshan 区域 ofnorthern 的可能同时代的床的 bohlini --大多数 Gansu , Suzhousaurus 早代表大知道之一 Cretaceoustherizinosauroids ,证明这 clade 它的进化历史上早达到了可观的身体尺寸。 | LI Daqing PENG Cuo YOU Hailu Matthew C. LAMANNA Jerald D. HARRIS Kenneth J. LACOVARA ZHANG Jianping | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 4 |
| 8 | An Optical Coherence Tomography-Guided, Variable Dosing Regimen with Intravitreal Ranibizumab (Lucentis) for Neovascular Age-related Macular Degeneration显示文摘 | Anne E. Fung Geeta A. Lalwani Philip J. Rosenfeld Sander R. Dubovy Stephan Michels William J. Feuer Carmen A. Puliafito Janet L. Davis Harry W. Flynn Maria Esquiabro | 2007 | American Journal of Ophthalmology2007，，4： | 3 |
| 9 | Xyloglucans of Monocotyledons Have Diverse Structures显示文摘除了在 Poaceae,很少在单子叶植物的主要的墙中对 xyloglucans 的结构被知道。在单子叶植物种类的一个范围的 Xyloglucan 结构被检验。墙准备被孤立,与 6 提取了 ? 与 xyloglucan 特定的 endo- 对待的 M 钠氢氧化物,和摘录(1 4 )-- glucanase 准备。释放的 oligosaccharides 被高效的阴离子交换层析并且由帮助矩阵的激光解吸附作用电离 time-of-flight 团 spectrometry 分析。non-commelinid 单子叶植物的 Oligosaccharide 侧面类似于大多数 eudicotyledons 的那些,显示 xyloglucans 是 fucogalactoxyloglucans,与 XXXG 一个核心主题和 fucosylated 单位 XXFG 和 XLFG。一个例外是 Lemna 未成年者(Araceae ) ,它没产出 fucosylated oligosaccharides 并且有 XXXG 和 XXGn 核心主题。除了 Arecales (手掌) 和 Dasypogonaceae,它有 fucogalactoxyloglucans, commelinid 单子叶植物的 xyloglucans 是在结构上不同。Zingiberales 和 Commelinales 与 XXGn 和 XXXG 核心主题有 xyloglucans;XXFG 单位的小比例,而是没有 XLFG 单位,是在场的。在 Poales, Poaceae 与一个 XXGn 核心主题和没有 fucosylated 单位有 xyloglucans。在另外的 Poales 家庭,一些有 XXXG 和 XXGn 核心主题,其它有仅仅 XXXG;XXFG 单位是在场的,但是 XLFG 单位不是。 | Yves S.Y. Hsieh Philip J. Harris | 2009 | Molecular Plant2009，2，5： | 3 |
| 10 | Early Repolarization: Electrocardiographic Phenotypes Associated With Favorable Long-Term Outcome显示文摘 | Jani T. Tikkanen M. Juhani Junttila Olli Anttonen Aapo L. Aro Samuli Luttinen Tuomas Kerola Solomon J. Sager Harri A. Rissanen Robert J. Myerburg Antti Reunanen Heikki V. Huikuri | 2011 | Circulation2011，，23： | 3 |
| 11 | Polymorphisms Near IL28B and Serologic Response to Peginterferon in HBeAg-Positive Patients With Chronic Hepatitis B显示文摘 | Milan J. Sonneveld Vincent W.–S. Wong Andrea M. Woltman Grace L.H. Wong Yilmaz Cakaloglu Stefan Zeuzem Erik H.C.J. Buster Andre G. Uitterlinden Bettina E. Hansen Henry L.Y. Chan Harry L.A. Janssen | 2012 | Gastroenterology2012，，3： | 3 |
| 12 | 大气等离子喷涂固体氧化物燃料电池用低温阴极材料显示文摘大气等离子喷涂由于能够快速制备具有可控微结构的功能涂层,在固体氧化物燃料电池(SOFCs)制造中具有广阔的应用前景。该技术使得低温运行(500~700℃)的SOFCs可通过在耐用低成本金属支撑体上直接喷涂得以制备。不过,目前商业应用的SOFCs所使用的标准阴极材料在较低运行温度下具有很高的极化电阻,因此,开发可替代的高性能低温阴极材料是推动金属支撑体应用的关键。在不锈钢基材上通过轴向注入大气等离子喷涂方法制备了镧锶钴铁氧化物(LSCF)涂层,并对涂层的厚度和微观结构进行了表征,同时采用X射线衍射(XRD)方法分析了等离子喷涂过程中涂层材料的分解和杂质相的产生。根据这些结果确定了能够制备LSCF涂层的等离子喷涂参数,以及可用于喷涂复合阴极涂层的条件范围。 | J. Harris O. Kesler 张鑫(译) 刘建明(校) | 2010 | 热喷涂技术2010，2，1： | 3 |
| 13 | Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis显示文摘 | Julian J. Lum Daniel E. Bauer Mei Kong Marian H. Harris Chi Li Tullia Lindsten Craig B. Thompson | 2005 | Cell2005，，2： | 3 |
| 14 | Diffusion tensor imaging (DTI) detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome (IBS)显示文摘 | Benjamin M. Ellingson Emeran Mayer Robert J. Harris Cody Ashe-McNally Bruce D. Naliboff Jennifer S. Labus Kirsten Tillisch | 2013 | Pain2013，，： | 2 |
| 15 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 16 | Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation显示文摘 | Anneke M. De Schryver Yolande C. Keulemans Harry P. Peters Louis M. Akkermans André J. Smout Wouter R. De Vries Gerard P. Van Berge-Henegouwen | 2005 | Scandinavian Journal of Gastroenterology2005，，4： | 2 |
| 17 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 18 | Concurrent measurement of (Na+,K+)-ATPase activity and lipid peroxides in rat brain following reversible global ischemia显示文摘 | William J. Goldberg Brant D. Watson Raul Busto Harry Kurchner Mercedes Santiso Myron D. Ginsberg | 1984 | Neurochemical Research1984，，12： | 2 |
| 19 | Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity显示文摘 | Kusum K. Kharbanda Sandra L. Todero Jordan C. Moats Ryan M. Harris Natalia A. Osna Paul G. Thomes Dean J. Tuma | 2014 | Alcohol Clin Exp Res2014，，3： | 2 |
| 20 | Changes in adrenal and testicular activity monitored by salivary sampling in males throughout marathon runs显示文摘 | N. J. Cook G. F. Read R. F. Walker B. Harris D. Riad-Fahmy | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，： | 2 |
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