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| 1 | The theory of economic regulation显示文摘 | Stigler J.George | | 0，，01： | 1 |
| 2 | Novel immunotherapy approaches for metastatic urothelial and renal cell carcinoma显示文摘The treatment of metastatic renal cell carcinoma(RCC)and urothelial carcinoma(UC)remains a major challenge.Past research has implicated the immune system in tumor surveillance of both malignancies,leading to the application of immunotherapy agents for both cancers.Among them,the most promising agents are the checkpoint blockade drugs,such as antibodies targeting the cytotoxic T-lymphocyte-associated antigen 4(CTLA-4),programmed death receptor 1(PD-1),and PD-1 ligand(PD-L1).In normal physiology,these immune checkpoints act as inhibitory signals to fine-tune the duration and strength of immune reactions,which is pivotal for maintaining self-tolerance.However,tumor cells also utilize immune checkpoint pathways to evade anti-tumor immune response,leading to disease progression and metastasis.Thus,there has been intense preclinical and clinical effort focused on the application of checkpoint inhibitors in metastatic RCC and UC.To date,nivolumab(anti-PD-1)and atezolizumab(anti-PD-L1)have been approved for the treatment of metastatic RCC and UC,respectively.Despite these successes,challenges remain in how to further improve response rates to immunotherapy and how to select patients that will benefit from this approach.In this report,we review existing data and research on immunotherapy in metastatic RCC and UC. | Zhiying Shao Andrew Z.Wang Daniel J.George Tian Zhang | 2016 | Asian Journal of Urology2016，3，4： | 1 |
| 3 | Determination of selected semi-volatile organic compounds in water using automated online solid-phase extraction with large-volume injection/gas chromatography/mass spectrometry显示文摘A rapid,sensitive,and cost-effective analyticalmethod was developed for the analysis of selected semivolatileorganic compounds in water.The method used anautomated online solid-phase extraction technique coupledwith programmed-temperature vaporization large-volumeinjection gas chromatography/mass spectrometry.Thewater samples were extracted by using a fully automatedmobile rack system based on x-y-z robotic techniquesusing syringes and disposable 96-well extraction plates.The method was validated for the analysis of 30 semivolatileanalytes in drinking water,groundwater,andsurface water.For a sample volume of 10 mL,the linearcalibrations ranged from 0.01 or 0.05 to 2.5μg·L^(-1),and themethod detection limits were less than 0.1μg·L^(-1).For thereagent water samples fortified at 1.0μg·L^(-1)and2.0μg·L^(-1),the obtained mean absolute recoveries were70%-130%with relative standard deviations of less than20%for most analytes.For the drinking water,groundwater,and surface water samples fortified at 1.0μg·L^(-1),theobtained mean absolute recoveries were 50%-130%withrelative standard deviations of less than 20%for mostanalytes.The new method demonstrated three advantages:1)no manipulation except the fortification of surrogatestandards prior to extraction;2)significant cost reductionassociated with sample collection,shipping,storage,andpreparation;and 3)reduced exposure to hazardous solventsand other chemicals.As a result,this new automatedmethod can be used as an effective approach for screeningand/or compliance monitoring of selected semi-volatileorganic compounds in water. | Yongtao LI Christina L.MCCARTY Ed J.GEORGE | 2011 | Frontiers of Environmental Science & Engineering2011，5，3： | 1 |
| 4 | Compatibility, Leisure, and Satisfaction in Marital Relationships显示文摘 | Duane W.Crawford Renate M.Houts Ted L.Huston Laura J.George | 2004 | Journal of Marriage and Family2004，，2： | 1 |
| 5 | Comparison of microbial and meiofaunal community analyses for determining impact of heavy metal contamination显示文摘 | Richard J. Ellis Barry Neish Marcus W. Trett J.George Best Andrew J. Weightman Philip Morgan John C. Fry | 2001 | Journal of Microbiological Methods2001，，3： | 1 |
| 6 | 各种阳牲乳剂的脊髓造影术显示文摘脊髓造影术一直是诊断脊髓和椎管病变的简单而又基本的方法。近来发现这种检查的缺点在很大强度上是由于造影剂不理想。本文报告对各种阳性乳剂进行的实验的研究。 | 储肖林 J.George Teqlick | 1986 | 颈腰痛杂志1986，9，3： | 0 |
| 7 | Understanding Performance for Two 802.11 Competing Flows显示文摘802.11 在面临竞争和干扰时受不了无效和不公平,是众所周知的。当二流动为上空与对方竞争时,这篇论文在网络性能上提供拓扑学和交通类型的影响的详细分析。我们考虑 TCP 和 UDP 流动和节点拓扑学的一个全面集合。我们改变这些拓扑学考虑下列四个 node-to-node 相互作用的所有联合:(1 ) 不能读或察觉到对方的节点,(2 ) 能察觉到对方的节点然而并非能读对方能交流与的包 ' 与 ' 节点(3 ) 弱并且与(4 ) 强壮的信号。我们通过盒子能与类似的效率 / 公平特征被归结为 9 UDP 和 10 个 TCP 802.11 g 模型的模拟和表演评估所有可能的盒子。我们也验证我们的模拟结果,广泛的实验在一张实验室试验床进行了。这些更多详细说明了模型在象 hidden-/exposed-terminal 分类那样的以前的工作上改善并且更好因此作为适应技术的一个基础被适合在 802.11 多跳跃 WLAN 或网格网络改进性能。 | Michael J.Feeley Brendan Cully Sharath J.George | 2008 | Journal of Computer Science & Technology2008，23，3： | 0 |
| 8 | The promise of immunotherapy in genitourinary malignancies显示文摘A broad understanding of the tumor immune landscape has led to a revolution of immune checkpoint inhibitors in the treatment of multiple cancer types.In genitourinary malignancies,immune checkpoint inhibitors have improved outcomes for patients with metastatic renal cell carcinoma and metastatic urothelial carcinoma;however,these treatments have not yet proven broadly beneficial for patients with metastatic prostate cancer.Numerous prospective trials are ongoing to further improve outcomes with immunotherapy combinations and for biomarker development to predict benefit from immune checkpoint inhibition.This perspective article highlights our current immunotherapy approaches in each of the genitourinary malignancies and the ongoing clinical trials that may inform our future treatments in renal,urothelial,and prostate cancers. | Tian Zhang Andrew J.Armstrong Daniel J.George Jiaoti Huang | 2018 | Precision Clinical Medicine2018，1，3： | 0 |
| 9 | 台式计算机化是一个连续的过程显示文摘本文首次对工作小组计算机化的连续过程进行纵向的、定量的分析。我们认为计算机化应被定义成连续的过程,而不象通常认为的静态过程。我们还认为计算机化也不象许多技术杂志上所描述的那种动态的变化。把计算机化看作是连续过程也隐含了在计算机化的小组中工作是如何变化的、以及我们如何研究工作的变化。为获取动态的信息和区分稳定和偶然的因素,在配置设备之后的较长时间内观察工作的变化并进行重复的观察是需要的。我们将介绍我们的研究成果,这些成果是对二年来在39个工作小组中,计算机化所起的作用的调查基础上取得的。在1999和1989年中,我们通过调查和访问收集了有关的数据。我们把计算机化过程分为四个要素:设备、基础条件、计算的社会组织和控制方式。对每个要素我们将提供有关的数据。在88到89年间,技术因素变得更复杂了(例如:设备种类,配备及使用的广度),社会因素(如:计算的基础条件)没有多大的变化。工作变化的初步分析表明,工作小组的工作更繁忙了。 | M.Zmuidzinas R.Kling J.George 祁伟 | 1991 | 计算机工程与应用1991，27，5： | 0 |
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