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| 1 | Brain-gut axis in the pathogenesis of Helicobacter pylori infection显示文摘Helicobacter pylori(H.pylori)infection is the main pathogenic factor for upper digestive tract organic diseases.In addition to direct cytotoxic and proinflammatory effects,H.pylori infection may also induce abnormalities indirectly by affecting the brain-gut axis,similar to other microorganisms present in the alimentary tract.The brain-gut axis integrates the central,peripheral,enteric and autonomic nervous systems,as well as the endocrine and immunological systems,with gastrointestinal functions and environmental stimuli,including gastric and intestinal microbiota.The bidirectional relationship between H.pylori infection and the brain-gut axis influences both the contagion process and the host’s neuroendocrine-immunological reaction to it,resulting in alterations in cognitive functions,food intake and appetite,immunological response,and modification of symptom sensitivity thresholds.Furthermore,disturbances in the upper and lower digestive tract permeability,motility and secretion can occur,mainly as a form of irritable bowel syndrome.Many of these abnormalities disappear following H.pylori eradication.H.pylori may have direct neurotoxic effects that lead to alteration of the brain-gut axis through the activation of neurogenic inflammatory processes,or by microelement deficiency secondary to functional and morphological changes in the digestive tract.In digestive tissue,H.pylori can alter signaling in the brain-gut axis by mast cells,the main brain-gut axis effector,as H.pylori infection is associated with decreased mast cell infiltration in the digestive tract.Nevertheless,unequivocal data concerning the direct and immediate effect of H.pylori infection on the brain-gut axis are still lacking.Therefore,further studies evaluating the clinical importance of these host-bacteria interactions will improve our understanding of H.pylori infection pathophysiology and suggest new therapeutic approaches. | Jacek Budzyński Maria Kopocka | 2014 | World Journal of Gastroenterology2014，20，18： | 29 |
| 2 | Usefulness of two independent hist classifications of tumor regression iUsefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy显示文摘AIM: To assess the usefulness of two independent histopathological classifications of rectal cancer regression following neo-adjuvant therapy. METHODS: Forty patients at the initial stage cT3NxM0 submitted to preoperative radiotherapy (42 Gy during 18 d) and then to radical surgical treatment. The relationship between “T-downstaging” versus regressive changes expressed by tumor regression grade (TRG 1-5) and Nasierowska-Guttmejer classification (NG 1-3) was studied as well as the relationship between TRG and NG versus local tumor stage ypT and lymph nodes status, ypN. RESULTS: Complete regression (ypT0, TRG 1) was found in one patient. “T-downstaging” was observed in 11 (27.5%) patients. There was a weak statistical significance of the relationship between “T-downstaging” and TRG staging and NG stage. Patients with ypT1 were diagnosed as TRG 2-3 while those with ypT3 as TRG5. No lymph node metastases were found in patients with TRG 1-2. None of the patients without lymph node metastases were diagnosed as TRG 5. Patients in the ypT1 stage were NG 1-2. No lymph node metastases were found in NG 1. There was a significant correlation between TRG and NG. CONCLUSION: Histopathological classifications may be useful in the monitoring of the effects of hyperfractionated preoperative radiotherapy in patientswith rectal cancer at the stage of cT3NxM0. There is no unequivocal relationship between “T-downstaging” and TRG and NG. There is some concordance in the assessment of lymph node status with ypT, TRG and NG. TRG and NG are of limited value for the risk assessment of the lymph node involvement. | ■ukasz Liszka Ewa Zielińska-Paj■k Jacek Paj■k Dariusz Goka Jacek Starzewski Zbigniew Lorenc | 2007 | World Journal of Gastroenterology2007，13，4： | 2 |
| 3 | Catalytic synthesis of higher aliphatic amines from the corresponding alcohols显示文摘 | Alfons B Jacek K | 1985 | Catalysis Reviews:Science and Engineering1985，27，4： | 1 |
| 4 | Direct observation of shape selectivity in zeolite ZSM-5 by magic-angle-spining NMR显示文摘 | Michael W A Jacek K | 1989 | Nature1989，339，： | 1 |
| 5 | Catalytic ozonation and methods of enhanceing molecular ozone reactions in water treatment 显示文摘 | Barbara K H Maria Z Jacek N | 2003 | Appl Catal B:Environ2003，46，： | 1 |
| 6 | Participation of polyamines in the flowering of the short-day plant Pharbitis nil显示文摘 | Marlena Z Jacek K Jan K | 2006 | Plant Growth Reguationl2006，50，23： | 1 |
| 7 | Treatment of Fourteen Chronic Active HBSAg^+ ,HBeAg^+ Hepatitis Patients with Low Dose Nature Human Interferon Alpha Administered Orally 显示文摘 | Wladyslawa Z Jacek P Anna K | 1993 | Arch lmmunol Ther Exp1993，41，： | 1 |
| 8 | Acupressure wristbands for the prevention of postoperative nausea and vomiting in adults undergoing cardiac surgery显示文摘 | Andrew A K George D Jacek K | | J Cardiothorac Vase Anesth 200 10，18，1： | 1 |
| 9 | Catalytic ozonation and methods of enhancing molecular ozone reactions in water treatment显示文摘 | Barbara K Maria Z Jacek N | 2003 | Applied Catalytic B2003，46，4： | 1 |
| 10 | Serum visfatin concentration is elevated in pregnant women irrespectively of the presence of gestational diabetes显示文摘 | Jacek S Mariusz K Beata T | 2009 | Ginekol Pol2009，80，1： | 1 |
| 11 | Catalytic ozonation and methods of enhancing molecular ozone reactions in water treatment显示文摘 | Barbara K Maria Z Jacek N | 2003 | Applied Catalysis B:Environmental2003，46，： | 1 |
| 12 | Catalytic ozonation and methods of enhancing molecular ozone reactions in water treatment显示文摘 | BARBARA K MARIA Z JACEK N | 2003 | Applied Catalysis B: Environmental2003，46，4： | 1 |
| 13 | Stochastic stability in three-player games显示文摘 | Dominik K Jacek M Marcin Z | 2005 | Bulletin of Mathematical Biology2005，67，6： | 1 |
| 14 | Taboo search:an approach to the multiple minima problem显示文摘 | Djurdje C Jacek K | 1995 | Science1995，267，3： | 1 |
| 15 | Two-and three-dimensional cadmium-organic frameworks with trimesic acid and 4,4′-trimethylenedipyridine显示文摘 | Filipe A Almeida P Jacek K | 2004 | Inorg Chem2004，43，： | 1 |
| 16 | Catalytic ozonation and methods of enhancing molecular ozone reactions in water treatment显示文摘 | Maria Z Jacek N | 2003 | Applied Catalysis B:Environmental2003，46，： | 1 |
| 17 | PBDEs in environmental sam- pies:sampling and analysis显示文摘 | Sylwia K Bozena Z Jacek N | 2012 | Talanta2012，93，15： | 1 |
| 18 | CDM based modeling of damage and fracture mechanisms in concrete under tension and compression显示文摘 | HALINA K C JACEK J S | 2004 | Engineering Fracture Mechanics2004，71，4： | 1 |
| 19 | Estimating Uncertainty in Analytical Procedures Based on Chromatographic Techniques 显示文摘 | Piotr K Jacek N S | 2010 | Journal of Chromatography A2010，1217，： | 1 |
| 20 | Ligand liposomes and BNCT显示文摘 | Carlsson J Erika B K Jacek C | 2003 | Journal of Neuro-Oncology2003，62，12： | 1 |
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