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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | Small bowel tumors detected and missed during capsule endoscopy: Single center experience显示文摘AIM:To characterize small bowel(SB)tumors detected by capsule endoscopy(CE),and identify missed tumors.METHODS:The study included 145 consecutive patients in whom 150 CEs were performed.Following CE,the medical records of the study population were reviewed.Results of double-or single-balloon enteroscopy performed after CE and the results of surgery in all patients operated on were retrieved.The patients were contacted through telephone interviews or postal mail.In addition,the national cancer registry and the polish clinical gastrointestinal stromal tumor(GIST)Registry were searched to identify missed neoplasms.RESULTS:Indications for CE included overt and occult obscure gastrointestinal bleeding(n=81,53.7%),anemia(n=19,12.7%),malabsorption(n=18,12%),abnormal CB follow through(n=9,6%),abdominal pain(n=7,5%),celiac disease(n=5,3%),neuroendocrine tumor(n=3,2%),Crohn’s disease(n=2,<2%),Peutz-Jeghers syndrome(n=2,<2%),other polyposes(n=2,<2%),and diarrhea(n=2,<2%).The capsule reached the colon in 115(76.6%)examinations.In 150 investigations,CE identified 15SB tumors(10%),14 of which were operated on or treated endoscopically.Malignancies included metastatic melanoma(n=1),adenocarcinoma(n=2),and GIST(n=3).Benign neoplasms included dysplastic Peutz-Jeghers polyps(n=4).Non-neoplastic masses included venous malformation(n=1),inflammatory tumors(n=2),and a mass of unknown histology(n=1).During the follow-up period,three additional SB tumors were found(2 GISTs and one mesenteric tumor of undefined nature).The National Cancer Registry and Polish Clinical GIST Registry revealed no additional SB neoplasms in the post-examination period(follow-up:range 4.2-102.5 mo,median 39 mo).The sensitivity of CE for tumor detection was 83.3%,and the negative predictive value was 97.6%.The specificity and positive predictive value were both 100%.CONCLUSION:Neoplasms may be missed by CE,especially in the proximal SB.In overt obscure gastrointestinal bleeding,complementary endoscopic and/or radiologic diagnostic tests are indicated. | Edyta S Zagorowicz Anna M Pietrzak Ewa Wronska Jacek Pachlewski Piotr Rutkowski Ewa Kraszewska Jaroslaw Regula | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 3 | {100}-textured, piezoeletrie Pb (Zrx, Ti1-x ) O3 thin films for MKMS: integration, deposition and properties 显示文摘 | NICOLAS L PAUL M JACEK B | 2003 | Sensors and Actuators A2003，105，2： | 1 |
| 4 | Neutrophils are active in total joint implant loosening显示文摘 | Waldemar W Jacek M Malgorzata WK | 2004 | Acta Orthop Scand2004，75，5： | 1 |
| 5 | Automated Diagnostics of Analog Systems Using Fuzzy Logic Approach显示文摘 | Piotr Bilski Jacek M W | 2007 | IEEE Transaction on Instrumentation and Measurement2007，56，6： | 1 |
| 6 | Leski On Support vector regression machines with linguistic interpretation of the kernel matrix显示文摘 | Jacek M | 2006 | Fuzzy Sets and Systerns2006，157，： | 1 |
| 7 | Groundwater-surface water interaction under scenarios of climate change using a high-resolution transient groundwater model显示文摘 | Jacek Scibek Diana M Allen Alex J Cannon Paul H Whitfield | 2006 | Journal of Hydrology2006，，8： | 1 |
| 8 | On-line preconcentration techniques in determination of melatonln and its preeursors/metabolites using micellar electrokinetic chromatography 显示文摘 | Jacek M Ewa P Marek T | 2006 | J ChromatogrA2006，1104，12： | 1 |
| 9 | Heat and mass transfer during microwave-convective drying显示文摘 | Stefan J Kowalski G M Jacek B | 2010 | American Institute of Chemical Engineers2010，56，： | 1 |
| 10 | Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland显示文摘 | Jacek G Monika B Tomasz M | 2013 | BMC Muscu- loskeletal Disorders2013，14，1： | 1 |
| 11 | Stochastic stability in three-player games显示文摘 | Dominik K Jacek M Marcin Z | 2005 | Bulletin of Mathematical Biology2005，67，6： | 1 |
| 12 | Effects of concentration on the performance of erbium-doped fiber amplifiers 显示文摘 | PIOTR M DUNG N JACEK C | 1997 | Journal of Lightzoave Technology1997，15，1： | 1 |
| 13 | Generalizecl core vector machines显示文摘 | Ivor W Tsang James T Kwok Jacek M Zurada | 2006 | IEEE Transactions on Neural Networks2006，17，5： | 1 |
| 14 | Inducible cAMP early repressor,an endogenous antagonist of cAMP responsive element-binding protein,evokes neuronal apoptosis in vitro显示文摘 | Jacek J Barbara M Amelia S | 2003 | J Neurosei2003，23，11： | 1 |
| 15 | GIS-based land-use suitability analysis: A critical overview 显示文摘 | Jacek M | 2004 | Progress in Planning2004，62，： | 1 |
| 16 | KOI HERPES VIRUS: DO ACIPENSERID RESTITUTION PROGRAMS POSE A THREAT TO CARP FARMS IN THE DISEASE-FREE ZONES?显示文摘 | Kempter Jolanta Sadowski Jacek Schütze Heike Fischer Uwe Dauber Malte Fichtner Dieter Panicz Remigiusz Bergmann Sven M | 2009 | Acta Ichthyologica et Piscatoria2009，，2： | 1 |
| 17 | Automated diagnostics of analog systems using fuzzy logic approach显示文摘 | BILSKI P JACEK M W | 2007 | IEEE Transactions on Instrumention and Measurement2007，56，6： | 1 |
| 18 | Ordered Weighted Averaging with Fuzzy Quantifiers:GIS-based Multicriteria Evaluation for Land-use Suitability Analysis显示文摘 | | 2006 | International Journal of Applied Each Observationand Geoinformation2006，8，4： | 1 |
| 19 | Ordered weighted averaging with fuzzy quantifiers: GIS-based multicriteria evaluation for land-use suitability anal- ysis显示文摘 | Jacek M | 2006 | International Journal of Applied Earth Observation and Geoinformation2006，，4： | 1 |
| 20 | A competitive layer model for cellular neural networks显示文摘 | Wei Zhou Jacek M Zurada | 2012 | Original Research Article Neural Networks2012，33，： | 1 |
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