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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | SMARCA4缺失型鼻窦癌:10例SWI/SNF驱动的鼻窦恶性肿瘤遗传学谱系的扩展显示文摘低分化鼻窦癌的分子发病机制近年来备受关注。在鼻窦未分化癌的形态学谱系中,几种未分类的癌被重新归类为具有独特遗传学特征的变异体或实体,包括NUT重排性癌和SMARCB1缺失型癌。作者进一步描述了一种罕见的鼻腔未分化癌样肿瘤,其特征是通过免疫组化染色可检测到SWI/SNF构建体SMARCA4(BRG1)的失活。 | Agaimy A Jain D Uddin N 魏建国(摘译) 袁晓露(审校) | 2020 | 临床与实验病理学杂志2020，36，5： | 8 |
| 3 | Data clustering:a review显示文摘 | JAIN A K MURTY M N FLYNN P J | 1999 | AGM Computing Surveys1999，31，3： | 2 |
| 4 | Phenotypic switching and its implications for the pathogenesis of cryptococcus neoformans 显示文摘 | Jain N Guerrero A Fries BC | 2006 | FEMS Yeast Res2006，6，4： | 1 |
| 5 | Multi-Objective placement of electronic components using evolutionary algorithms显示文摘 | DEB K JAIN P GUPTA N | 2004 | IEEE Transactions on Components and Packaging Technologies2004，27，3： | 1 |
| 6 | Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor显示文摘 | JAIN RK SAFABAKHSH N SCKELL A | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 7 | Aspiration cytology of focal xanthogranulomatous pyelonephritis:a diagnostic challenge显示文摘 | Kumar N Jain s | 2004 | Diagn Cytopathol2004，30，2： | 1 |
| 8 | The D-domain of Sp3modulates its protein levels and activation of the p21CIP1/WAF1promoter显示文摘 | Hammill D Jain N Armstrong S | 2005 | Biochem Biophys Res Commun2005，335，： | 1 |
| 9 | Combined effect of SLS and (SBE) (7M)-β-CD on the solubilization of NSC-639829显示文摘 | Yang G Jain N Yalkowsky SH | 2004 | Int J Pharm2004，269，： | 1 |
| 10 | Modeling the Effect of Twinning and Detwinning During Strain-Path Changes of Magnesium Alloy AZ31 显示文摘 | PROUST G TOME C N JAIN A | 2009 | International Journal of Plasticity2009，25，5： | 1 |
| 11 | Two new novel pointmutations localized upstream and downstream of the HMG box region of the SRY gene in three Indian 46,XY females with sex reversal and gonadal tumour formation显示文摘 | Shahid M Dhillion VS Jain N | 2004 | Mol Hum Reprod2004，10，7： | 1 |
| 12 | The twin-twin transfusion syndrome 显示文摘 | Jain V Fisk N Frcog | 2004 | Clin Obstet Gyneco12004，47，1： | 1 |
| 13 | Deactivation and reactivation of somatosen- sory cortex after dorsal spinal cord injury显示文摘 | Jain N Catania KC Kaas JH | 1997 | Nature1997，386，6624： | 1 |
| 14 | Genome-wide transcriptomic analysis of cotton under drought stress reveal significant down-regulation of genes and pathways involved in fibre elongation and up-regulation of defense responsive genes显示文摘 | Kethireddy Venkata Padmalatha Gurusamy Dhandapani Mogilicherla Kanakachari Saravanan Kumar Abhishek Dass Deepak Prabhakar Patil Vijayalakshmi Rajamani Krishan Kumar Ranjana Pathak Bhupendra Rawat Sadhu Leelavathi Palakolanu Sudhakar Reddy Neha Jain Kasu N | 2012 | Plant Molecular Biology2012，，3： | 1 |
| 15 | Upper respiratory tract infections 显示文摘 | Jain N Lodha R Kabra SK | 2001 | Indian JPed2001，68，12： | 1 |
| 16 | Impact of interference on multi-hop wireless network performance 显示文摘 | Jain K Padhye J Padmanabhan V N | 2005 | Wireless Networks2005，11，4： | 1 |
| 17 | Dynamics of urbanization:the empirical validation of the replacement hypothesis显示文摘 | Rao D N Karmeshu Jain V P | 1989 | Environment and Planning B: Planning and Design1989，16，3： | 1 |
| 18 | Simulation of soil moisture profiles for scheduling of irrigations显示文摘 | Jain A K Murty V V N | 1985 | Agricultural Water Management1985，10，2： | 1 |
| 19 | Degradation of predi- gested distillery effluent by isolated bacterial strains显示文摘 | JAIN N MINOCHA A K VERMA C L | 2002 | Indian Journal of Experimental Biology2002，40，1： | 1 |
| 20 | An efficient and convenient microwave-assisted chemical synthesis of(thio)xanthones with additional in vitro and in silico characterization 显示文摘 | Verbanac D Jain S C Jain N | 2012 | Bioorg Med Chem2012，20，10： | 1 |
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