|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors显示文摘AIM:To investigate primarily the prognostic value of Ki-67,as well as other parameters,in gastrointestinal stromal tumors(GISTs).METHODS:Ki-67,c-KIT,platelet-derived growth factor receptor-alpha(PDGFRα),smooth muscle actin(SMA),CD34,S100 were stained for immunohistochemistry which was performed on formalin-fixed,paraffinembeded sections on representative block from each case.Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells.Immunoreactivity for c-KIT and PDGFRα was evaluated semiquantitatively(weak,intermediate,strong) and for c-KIT type of reactivity was analyzed(cytoplasmic,membrane and 'dot-like' staining).Immunoreactivity for SMA,CD34 and S100 were was evaluated as positive or negative antigen expression.Pathologic parameters investigated in this study included tumor size,cell type(pure spindle,pured epitheloid mixed spindle and epitheloid),mitotic count,hemorrhage,necrosis,mucosal ulceration.Clinical data included age,gender,primary tumor location and spread of disease.χ 2 test and Student's t-test were used for comparisons of baseline characteristics.The Cox's proportional hazard model was used for univariable and multivariable analyses.Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test.RESULTS:According to the stage of disease,there were 36 patients with localized disease,29 patients with initially localized disease but with its recurrence in the period of follow up,and finally,35 patients had metastatic disease from the very beginning of disease.Tumor originated most commonly in the stomach(41%),small intestine was the second most common location(36%).The mean size of primary tumors was 6.5 cm.The mean duration of follow-up was 60 mo.Multiple parameters were analyzed for their effect on overall survival,but no one reached statistical significance(P = 0.06).Analysis of time to progression/relapse in initially localized disease(univariate analysis),tumor size,mitotic count,Ki-67 and type of d-KIT distribution(cytoplasmic vs membrane/'dot-like') showed statistically significant correlation.In multivariate analysis in the group of patients with localized disease,there were only 2 parameters that have impact on relapse,Ki-67 and SMA(P < 0.0001 and P < 0.034,respectively).Furthermore,Ki-67 was analyzed in localized diseasevs localized with recurrence and metastatic disease.It was shown that there is a strict difference between these 2 groups of patients(median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease,P < 0.0001).It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%.The curves for survival on that cut-off level are significantly different(P < 0.04,Cox F).CONCLUSION:Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease. | Borislav Belev Iva Bri Juraj Prejac Zrna Antunac Golubi Damir Vrbanec Jadranka Bozikov Ivan Aleri Marko Boban Jasminka Jaki Razumovi | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 2 | Ocular bubble formation as a method of assessing decompression stress显示文摘 | CAMPBELL D G JAKI P DOVSAK P A | 1998 | Undorsea Hyperb Med1998，25，4： | 1 |
| 3 | The coefficient of earth pressure at rest显示文摘 | JAKY J | 1944 | Journal for Society of Hungarian Architects and Engineers Budapest Hungary1944，1944，： | 1 |
| 4 | A routine experimental protocol for qHNMR illustrated with taxol显示文摘 | Pauli GF Jaki BU Lankin DC | 2007 | J Nat Prod2007，70，4： | 1 |
| 5 | Quantitative 1HNMR:development and potential of a method for natural products analysis显示文摘 | PAULI G F JAKI B U LANKIN D C | | 0，，01： | 1 |
| 6 | Influence of carbon black type on anode and cathode electrical properties in Li/SOCl2 batteries显示文摘 | Jaki M Gaberek K | 1995 | Electrochimica Acta1995，40，17： | 1 |
| 7 | The Coefficient of Earth Pressure at Rest显示文摘 | Jaky J | 1944 | Journal for Society of Hungarian Architects and Engineers1944，10，： | 1 |
| 8 | Quantitative 1H NMR:development and potential of a method for natural products analysis显示文摘 | Pauli GF Jaki BU Lankin DC | 2005 | J Nat Prod2005，68，1： | 1 |
| 9 | Quantitative ^1 H- NMR and its development and potential of method for natural products analysis 显示文摘 | Pauli G F Jaki B U Lankin D C | 2005 | J Nat Prod2005，68，1： | 1 |
| 10 | New Antibacterial Metabolites from the Cyanobacterium Nostoc commune(EAWAG 122b)显示文摘 | Jaki B Orjala J Heilmann J | 2000 | Journal of Natural Products2000，63，9： | 1 |
| 11 | Efficacy of eprinomectin against mange mitesin cattle 显示文摘 | Dietrich B Jakie A H Bruce N K etal | 1997 | Am J Vet Res1997，58，11： | 1 |
| 12 | Quantitative NMR of bioactive natural products 显示文摘 | Pauli G F Jaki B U Lankin D C | 2008 | Bioactive Nat Prod2008，2，： | 1 |
| 13 | Becoming a teacher: encouraging development of teacher identity through reflective practice 显示文摘 | Jakie Wa|kington | 2005 | Asia-Pacific Journal of Teacher Education2005，33，1： | 1 |
| 14 | A routine experimental protocol for qHNMR illustrated with taxol 显示文摘 | Pauli G F Jaki B U Lankin D C | 2007 | J Nat Prod2007，70，4： | 1 |
| 15 | Correlation of two methods for determination of cathepsin D in breast carcinoma (immunohistochemistry and ELISA in cytosol)显示文摘 | Uasminka Jaki? Razumovi? Ranka Romi? Stojkovi? Mladen Petrove?ki Stjepan Gamulin | 1997 | Breast Cancer Research and Treatment1997，，2： | 1 |
| 16 | Diabetic nephropathy and prevention of diabetic nephropathy caused chronic renal insufficiency显示文摘 | Jaki(c) M Jaki(c)M Zibar L | 2009 | Lijec Vjesn2009，131，78： | 1 |
| 17 | Quantitative ^1H NMR: developmen and potential of a method for natural products analysis显示文摘 | Pauli G F Jaki B U Lankin D C | 2005 | J Nat Prod2005，68，1： | 1 |
| 18 | Purityactivity relationships of natural products: the case of anti- TB active ursolic acid显示文摘 | Jaki B U Franzblau S G Chadwick L R | 2008 | J Nat Prod2008，71，10： | 1 |
| 19 | Development of an extraction method for mycobacterial metabolome analysis显示文摘 | Jaki BU Franzblau SG Cho SH | 2006 | J Pharm Biomed Anal2006，41，1： | 1 |
| 20 | The chemical vapour transport growth of ZnO single crystals 显示文摘 | Mycielski A Kowalczyk L Szadkowski A Chwalisz B Wysmoek A Baranowski J M Potemski M Witowski A Jaki R Barcz A Witkowska B Kaliszek W Jedrzejczak A Suchock A Lusakowska E Kaminska E | 2004 | Journal of Alloys and Compounds2004，371，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员