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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | RUNOFF-ENERGY FACTORS FORMUSLE SEDIMENT-YIELD MODEL FOR SURFACE MINES显示文摘The Modified Universal Soil Loss Equation (MUSLE) is often used for sediment-yield estimations insurface mines for design and impact evaluations. However, it is not known if the widely-used runoff-energy factor of MUSLE is appropriate, or if its parameters are the same for surface mines as foragricultural watersheds from which MUSLE was developed. Suspended-sediment data from threeexperimental watersheds in Ohio (approximately 1O - 2O ha), subjected to near complete distUrbance dueto mining and reclamation, were used to investigate five altemate runoffenergy factors in the MUSLEsediment-yield model for use in surface mines. The evaluation led to the selection of the generalizedmodel form, a (runoff volume X peak flow rate)b, as the best choice among models investigated.Exponent b was greater than the widely-used value of 0.56, ranging from 0.68 to 1. 10. Parameter b wasdependent on whether mining-or reclamation-related watershed activities were predominam. Theoriginal Williams (1975) model fit the data least well of the five energy factors studied. | James V. Bonta(Research Hydraulic Engineer, USDA-Agriculture Research Service, North Appalachian Experimental Watershed,P.O. Box 488, Coshocton, OH 43812. email:bonta@coshocton.com ) | 2000 | International Journal of Sediment Research2000，15，2： | 4 |
| 3 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 4 | Patient and provider perceptions of diabetes: Measuring and evaluating differences显示文摘 | James T. Fitzgerald R. Brent Stansfield Tricia Tang Mary Oh Alice Frohna Betty Armbruster Larry Gruppen Robert Anderson | 2007 | Patient Education and Counseling2007，，1： | 1 |
| 5 | Noninvasive Diagnosis of Ischemia-Causing Coronary Stenosis Using CT Angiography显示文摘 | Yeonyee E. Yoon Jin-Ho Choi Ji-Hyun Kim Kyung-Woo Park Joon-Hyung Doh Yong-Jin Kim Bon-Kwon Koo James K. Min Andrejs Erglis Hyeon-Cheol Gwon Yeon Hyeon Choe Dong-Ju Choi Hyo-Soo Kim Byung-Hee Oh Young-Bae Park | 2012 | JACC: Cardiovascular Imaging2012，，11： | 1 |
| 6 | The critical size defect as an experiment model to test bone repair materials显示文摘 | Eddrey Oh James CK | 1990 | J Craniofacial Surg1990，1，1： | 1 |
| 7 | Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis显示文摘 | Qian Zhou Yu Mei Takuhito Shoji Xinbing Han Karol Kaminski Goo Taeg Oh Pat P. Ongusaha Kunzhong Zhang Hannah Schmitt Martin Moser Christoph Bode James K. Liao | 2012 | Circulation2012，，18： | 1 |
| 8 | Fractures of the head and neck of the femur in children显示文摘 | Lavrie OH James HB | 1992 | J Bone Joint Surg(Am)1992，26，2： | 1 |
| 9 | Fractures of the head and neck of the femur in children显示文摘 | Lavarie OH James HB | 1994 | J Bone Joint Surg Am1994，26，2： | 1 |
| 10 | Fractures of the head and neck of the femur in children 显示文摘 | James HB | 1994 | J Bone Joint Surg(Am)1994，26，2： | 1 |
| 11 | Type-Selective Benefits of Medications in Treatment of Acute Aortic Dissection (from the International Registry of Acute Aortic Dissection [IRAD])显示文摘 | Toru Suzuki Eric M. Isselbacher Christoph A. Nienaber Reed E. Pyeritz Kim A. Eagle Thomas T. Tsai Jeanna V. Cooper James L. Januzzi Alan C. Braverman Daniel G. Montgomery Rossella Fattori Linda Pape Kevin M. Harris Anna Booher Jae K. Oh Mark Peterson Vija | 2012 | The American Journal of Cardiology2012，，1： | 1 |
| 12 | Diagnostic Value of Echocardiography in Cardiac Tamponade显示文摘 | Teresa S.M. Tsang Jae K. Oh James B. Seward A. Jamil Tajik | 2000 | Herz2000，，8： | 1 |
| 13 | Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women显示文摘 | Teresa S.M Tsang Bernard J Gersh Christopher P Appleton A.Jamil Tajik Marion E Barnes Kent R Bailey Jae K Oh Cynthia Leibson Samantha C Montgomery James B Seward | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 14 | Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis显示文摘 | Matthew W. Carroll Doosoo Jeon James M. Mountz Jong Doo Lee Yeon Joo Jeong Nadeem Zia Myungsun Lee Jongseok Lee Laura E. Via Soyoung Lee Seok-Yong Eum Sung-Joong Lee Lisa C. Goldfeder Ying Cai Boyoung Jin Youngran Kim Taegwon Oh Ray Y. Chen Lori E. Dodd W | 2013 | Antimicrobial Agents and Chemotherapy2013，，8： | 1 |
| 15 | Development of a composite vascular scaffolding system that withstands physiological vascular conditions显示文摘 | Sang Jin Lee Jie Liu Se Heang Oh Shay Soker Anthony Atala James J. Yoo | 2008 | Biomaterials2008，，19： | 1 |
| 16 | Energy Conserving Equations of Motion for Gear Systems 显示文摘 | OH Sejoong GROSH Karl BARBER James R | 2005 | ASME Journal of Vibration and Acoustics2005，127，4： | 1 |
| 17 | Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis显示文摘 | Rick B. Vega Koichi Matsuda Junyoung Oh Ana C. Barbosa Xiangli Yang Eric Meadows John McAnally Chris Pomajzl John M. Shelton James A. Richardson Gerard Karsenty Eric N. Olson | 2004 | Cell2004，，4： | 1 |
| 18 | MR imaging findings in 76 consecutive surgically proven cases of pericardial disease with CT and pathologic correlation显示文摘 | PhillipM Young James F Glockner Eric E Williamson Michael F Morris Philip A Araoz Paul R Julsrud Hartzell V SchafiF William D Edwards Jae K Oh Jerome F Breen | 2012 | The international journal of cardiovascular imaging2012，28，5： | 1 |
| 19 | Obesity and the Environment显示文摘 | James OH Holly RW George WR | 2003 | Science2003，299，： | 1 |
| 20 | Environment contributions to the obesity epidemic显示文摘 | James OH John CP | 1998 | Science1998，280，29： | 1 |
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