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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 3 | Attenuation of mitochondrial,but not cytosolic,Ca^(2+) overload reduces myocardial injury induced by ischemia and reperfusion显示文摘瞄准:mitochondrial Ca2+ 的变细([Ca2+] m ) ,然而并非 cytosolic Ca2+([Ca2+] c ) ,超载改进可收缩的恢复。我们假设了那变细[Ca2+] m,然而并非[Ca2+] c,超载对 ischemia/reperfusion-induced 损害授与 cardioprotection。方法:从孤立的酒的老鼠心,房间生存能力,和在孤立的老鼠短暂的电子上导致的 Ca2+ 的梗塞尺寸室的 myocytes 被测量。我们决定了 BAPTAAM 的效果,一座Ca2+螯岩山,在废除两个的超载的集中[Ca2+] c 并且[Ca2+] m ,和钌红,Ca2+的 mitochondrial uniporter 的一个禁止者搬运,在废除超载的集中[Ca2+] m ,然而并非[Ca2+] c ,在 ischemia/reperfusion 导致的心脏的损害上。结果:两个的变细[Ca2+] m 并且[Ca2+]由 BAPTAAM 的 c ,和变细[Ca2+] m ,然而并非[Ca2+] c ,由钌红的超载,减少了心脏的损害观察,显示重要性[Ca2+]在响应 ischemia/reperfusion 的 cardioprotection 和可收缩的恢复的 m 。结论:学习用一条原因效果途径提供了不含糊的证据那变细[Ca2+] m,然而并非[Ca2+] c,超载为对 ischemia/reperfusion-induced 损害的 cardioprotection 负责。我们也证实了以前的观察那变细[Ca2+] m,然而并非[Ca2+] c,旁边钌红改进可收缩的恢复追随者 ischemia/reperfusion。 | Chun-mei CAO Wing-yee YAN Jing LIU Kenneth WL KAM Shi-zhong ZHAN James SK SHAM Tak-ming WONG | 2006 | Acta Pharmacologica Sinica2006，27，7： | 4 |
| 4 | Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome显示文摘 | James SK Armstrong P Barnathan E | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 5 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST - segment elevation 显示文摘 | Task Force on the management of ST - segment elevation acute myocardial infarction of the European Society of Cardiology ( ESC ) Steg PG James SK | 2012 | Eur Heart J2012，33，20： | 1 |
| 6 | Regulation of retinoic acid receptor-β expression by peroxisome proliferator-activated receptor γ ligands in cancer cells显示文摘 | James SY Lin F Kolluri SK | 2003 | Cancer Res2003，63，13： | 1 |
| 7 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation显示文摘 | Steg PG James SK Atar D | 2012 | Eur Heart J2012，33，20： | 1 |
| 8 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation显示文摘 | STEG PG JAMES SK ATAR D | 2012 | Eur Heart J2012，33，20： | 1 |
| 9 | Long-term outcomes with drug-eluring stents versus bare-metal stents in Sweden 显示文摘 | Lagerqvist B James SK Stenestrand U | 2007 | N Engl J Med2007，356，10： | 1 |
| 10 | Long-term out-comes with drug-eluting stents versus bare-metal stents in Swe-den 显示文摘 | Lagerqvist B James SK Stenestrand U | 2007 | NEngl JMed2007，356，10： | 1 |
| 11 | ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation 显示文摘 | Steg PG James SK Atar D | 2012 | Eur Heart J2012，33，20： | 1 |
| 12 | N-terminal pro-brain natriuretic peptide and other risk factors for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease:a Global Utilization of Strategies To Open Occluded Arteries (GUSTO) IV substudy 显示文摘 | James SK Lindahl B Siegbahn A | 2003 | Circulation2003，108，3： | 1 |
| 13 | N - terminal pro - brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease 显示文摘 | James SK Lindahl B Siegbahn A | 2003 | Circulation2003，108，： | 1 |
| 14 | N-terminal pro- brain natriuretic peptide and other risk markers for the sep- arate prediction of mortality and subsequent myocardial in- farction in patients with unstable coronary artery disease:a global utilization of strategies to open occluded arteries (GUSTO) -IV sub-study 显示文摘 | James SK Lindahl B Siegbahn A | 2003 | Circulation2003，108，3： | 1 |
| 15 | ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation显示文摘 | Task Force on the Management of ST-segment Elevation Acute Myo- cardial Infarction of the European Society of Cardiology ( ESC ) Steg PG James SK | 2012 | Eur Heart J2012，33，20： | 1 |
| 16 | ESC Guide- lines for the management of acute myocardial infarction in patients presenting with ST - segment elevation 显示文摘 | Task Force on the management of ST - segment elevation a- cute myocardial infarction of the European Society of Car- diology (ESC) Steg PG James SK | 2012 | Eur Heart J2012，33，20： | 1 |
| 17 | N-terminal-pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease:a Global Utilization of Strategies To Open occlude arteries( GUSTO)-Ⅳ substudy显示文摘 | James SK Lindahl B Siegbahn A | 2003 | Circulation2003，108，： | 1 |
| 18 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation显示文摘 | Steg PG James SK Atar D | | 0，，20： | 1 |
| 19 | ESC guidelines for management of acute myocardial infarction in patients presenting with ST-segment elevation显示文摘 | Steg PG James SK Atar D | 2012 | Eur Heart J2012，33，20： | 1 |
| 20 | Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for noninvasive management:substudy from prospective randomised PLATelet inhibition and patient Outcomes(PLATO)trial显示文摘 | James SK Roe MT Cannon CP | 2011 | BMJ2011，，342： | 1 |
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