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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 3 | Automatic adaptive grid refine ment for the euler equations 显示文摘 | Berger M Jameson A | 1985 | AIAA J1985，23，： | 2 |
| 4 | 显示文摘 | Goebel Dan M Watkins Ron M Jameson Kristina K | 2007 | Propul Power2007，23，3： | 1 |
| 5 | Aggregate structures formed via a bridging flocculation mechanism 显示文摘 | Biggs S Habgood M Jameson G J | 2000 | Chemical Engineering Journal2000，0，13： | 1 |
| 6 | Human follicle- stimulating hormone beta -subunit gene encodes multiple messenger ribonucleic acids显示文摘 | Jameson J L Becker C B Lindell C M | 1958 | Mol Endocrinol1958，2，9： | 1 |
| 7 | Fluorescence anisotropy ap- plied to biomolecular interactions显示文摘 | Jameson D M Sawyer W H | 1995 | Methods in Enzy- mology1995，246，： | 1 |
| 8 | Positive selection of thymocytes显示文摘 | Jameson S C Hogquist K R Bevan M J | 1994 | Annu Rev Immunol1994，13，： | 1 |
| 9 | Emotion in Conflict Formation and Its Transformation:Application to Organizational Conflict Management 显示文摘 | BODTKER A M JAMESON J K | 2001 | International Journal of Confliet Management2001，12，3： | 1 |
| 10 | Advances in the study of high intensity conditioning as a means of improving mineral flotation performance 显示文摘 | ENGEL M D MIDDLEBROOK P D JAMESON G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 11 | Prediction of the Bubble Size Generated by a Plunging Liquid Jet Bubble Column显示文摘 | Evans G M Jameson G J Atkinson B W | 1992 | Chem Eng Sci1992，47，： | 1 |
| 12 | Phase II study ofASA404(vadimezan,5,6-dimethylxanthenone-4-acetic acid/DMXAA)1800 mg/m2 combined with carboplatin and paclitax-el in previously untreated advanced non-small cell lung cancer显示文摘 | McKeage MJ Reck M Jameson MB | 2009 | Lung Cancer2009，65，2： | 1 |
| 13 | Human follicle -stimulating hormone(3 -subunit gene en -codes multiplemessenger ribonucleic acids 显示文摘 | Jameson J L Becker C B Lindell C M | 1988 | Mol Endocrinol1988，2，9： | 1 |
| 14 | Mass transfer from very small bubbles-the optimum bubble size for aeration 显示文摘 | Motarjemi M Jameson G J | 1978 | Chemical Engineering Science1978，，33： | 1 |
| 15 | Wound complications following rivaroxaban administration: a muhicenter comparison whh low-molecular-weight heparins for thromboprophylaxis in lower limb arthroplasty显示文摘 | Jameson S S Rymaszewska M Hui A C | 2012 | J Bone Joint Surg Am2012，94，： | 1 |
| 16 | A ral for skin gammadelta T cell in wound repair 显示文摘 | JAMESON M UGARTE K CHEN N | 2002 | Science2002，296，： | 1 |
| 17 | Advances in the study of high intensity conditioning as-ameans of improving mineral flotation performance 显示文摘 | Engel M D Middlebrook Jameson G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 18 | Development of an in Vitro Assay for Clostridium botulinum Type B Neurotoxin in Foods That Is More Sensitive Than the Mouse Bioassay 显示文摘 | Wictome M K Newton K Jameson | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 19 | Prediction of the bubble size generated by a plunging liquid jet bubble column显示文摘 | Evans G M Jameson G J Atkinson B W | 1992 | Chem Eng1992，47，1314： | 1 |
| 20 | Human follicle-stimulating hormone β-subunit gene encodes multiple messenger ribonucleic acids 显示文摘 | JAMESON J L BECKER C B LINDELL C M | 1988 | Molecu- lar Endocrinology1988，2，9： | 1 |
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