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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Enhancement of the fertilizer value of rock phosphate engineered through phosphate- solubilizing bacteria显示文摘 | Sahu S N and Jana B B | 2000 | Ecol Engineering2000，15，： | 3 |
| 3 | Wet chemical synthesis of silver nanorods and nanowires of controllable aspect ratios显示文摘 | Jana N R Gearheart L Murphy C | 2001 | J Chem Commun2001，，： | 1 |
| 4 | Thermal stability and molecular interaction of polyurethane nanocomposites prepared by in situ polymerization with functionalized multiwalled carbon nanotubes显示文摘 | Jana R N Cho W | 2008 | J Appl Polym Sci2008，108，： | 1 |
| 5 | Robust scale-adaptive mean- shift for tracking显示文摘 | Tomas V Jana N and Jiri M | 2013 | Lecture Notes in Computer Science2013，，7944： | 1 |
| 6 | Evidence for Seed-Mediated Nucleation in the Chemical Reduction of Gold Salts to Gold Nanoparticles显示文摘 | Jana N R Gearheat L Murphy L | 2001 | J Chem Mater2001，13，： | 1 |
| 7 | MAPK p38 regulates transcriptional activity of NF-kappa B in primary human astroeytes via acetylation of p65 显示文摘 | SAHA R N JANA M PAHAN K | 2007 | J Immunol2007，179，10： | 1 |
| 8 | Effect of herbicides on decomposition of soil organic matter and mineralization of nitrogen in fluventic ustochrept soil显示文摘 | JANA T K DEBNATH N C BASAK R K | 2004 | Journal of Interacademicia2004，8，2： | 1 |
| 9 | Seed - Mediated Growth Approach for Shape - Controlled Synthesis of Spheroidal and Rod - like Gold Nanoparticles Using a Suffactant Template 显示文摘 | N R Jana L Gearheart C J Murphy | 2001 | Adv Mater2001，13，： | 1 |
| 10 | Size and shape-controlled magnetic (Cr, Mn, Fe, Co, Ni) oxide nanocrystals via a simple and general approach 显示文摘 | Jana N R Chen Y F Peng X G | 2004 | Chemistry Materials2004，16，： | 1 |
| 11 | Fluorescent Carbon Nanoparticles: Synthesis, Characterization,and BioimagingApplication 显示文摘 | RAY S C SAHA A JANA N R | 2009 | Journal of Physical Chemistry C2009，113，18： | 1 |
| 12 | High-rate uncorrelated bit extraction for shared secret key generation from channel measurements显示文摘 | Patwari N Croft J Jana S | 2010 | IEEE Transactions on Mobile Computing2010，9，1： | 1 |
| 13 | 7 regulation of the yeast general amino acid control pathway in response to nutrient stress显示文摘 | Ronald C W Kirk A S Jana N | 2004 | Topics in Current Genetics2004，7，： | 1 |
| 14 | A qualita- tive systematic review of head-to-head randomized con- trolled trials of oral analgesics in neuropathic pain显示文摘 | C Peter N Watson Ian Gilron Jana Sawynok | 2010 | Pain Res Manag2010，15，3： | 1 |
| 15 | Secret key extraction from wireless signal strength in real environments 显示文摘 | PREMNATH S N JANA S CROFT J | 2013 | I EEE Trans on Mo- bile Computing2013，12，5： | 1 |
| 16 | Fluorescent carbon nano- particles:Synthesis, characterization, and bioimaging appli cation显示文摘 | Ray S C Saha A Jana N R | 2009 | J Phys Chem C2009，113，18： | 1 |
| 17 | Fluorescent carbon nanoparti- cles: Synthesis, characterization, and bioimaging application显示文摘 | Ray S C Saha A Jana N R | 2009 | J Phys Chem C2009，113，18： | 1 |
| 18 | Langmuir-Btodgett thin films of quantum dots : synthesis, surface modification and fluorescence resonance energy transfer (FRET) studies 显示文摘 | Gole A Jana N R Selvan S T | 2008 | Langmuir2008，24，15： | 1 |
| 19 | rubber as effec blends of LDPE and PDMS tire cable, insulants显示文摘 | Jana Compatibilised R N Nando G B Khastgir D | 2003 | Plastics Rubber and Composites2003，32，1： | 1 |
| 20 | Seed-Mediated Growth Approach for Shape-Controlled Synthesis of Spheroidal and Rod-Like Gold Nanoparticles Using a Surfaetant Template显示文摘 | Jana N R Gearheart L Murphy C J | 2001 | Advanced Materials2001，13，18： | 1 |
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