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| 1 | 互联网对高等教育未来的影响显示文摘互联网的出现在一定程度上正在改变着人类的生存方式和学习方式。本文是佩尤研究中心'互联网的未来'系列研究成果中的一部分。'互联网的未来'旨在捕捉人们对互联网未来的期望,展现人们目前的观点。本文认为:到2020年,市场因素将推动大学不断开发网络课程,创造混合学习空间,向'终身学习模式'和多样化教育认证结构转型。但是,对于这些强大的力量会以何种方式或好或坏地影响教育,他们持有不同意见。专家们期待更高效的协作环境和新的评价系统;他们担心大量的网络课程会逐渐取代校园生活。 | Janna Q.Anderson Jan L.Boyles Lee Rainie 王景枝 王保华 | 2013 | 高等工程教育研究2013，61，3： | 37 |
| 2 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘The miR-15/107 family comprises a group of 10 paralogous microRNAs(miRNAs),sharing a 50AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations(enriched for cortical neurons,astrocytes and microglia,respectively).In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system(CNS).In addition to mature miRNAs,we also examined the expression of precursors(pri-miRNAs).Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. | Wang-Xia Wang Robert J.Danaher Craig S.Miller Joseph R.Berger Vega G.Nubia Bernard S.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson | 2014 | Genomics, Proteomics & Bioinformatics2014，12，1： | 9 |
| 3 | Reverse-Time Migration from Rugged Topography to Image Ground-Penetrating Radar Data in Complex Environments显示文摘探地雷达偏移成像中,基于高程静校正的基准面偏移方法对起伏地表下的复杂地层成像效果较差。为了优化成像效果,本文提出了一种基于麦克斯韦方程组二阶解耦形式的逆时偏移成像(reversetime migration,RTM)算法,该算法特点在于只需计算电场,且可直接从采集面而非基准面进行波场延拓,进而实现地形逆时偏移。数值模拟比较了高程静校正偏移方法和RTM方法在地表起伏及速度横向变化情况下的成像效果,结果证明RTM方法成像效果更好。为了进一步验证算法效果,利用美国犹他州珊瑚粉沙丘崎岖地形下的实测数据对两种方法进行了对比分析。研究表明,逆时偏移成像方法能够极大地提高复杂环境下探地雷达深度成像精度。 | John H. Bradford Janna Privette David Wilkins Richard Ford | 2018 | Engineering2018，4，5： | 5 |
| 4 | Strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)显示文摘The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker.In the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)imaging.We have synthesized potential small molecule radiotracers for both the intracellular([18F]InRAGER)and extracellular([18F]RAGER)domains of RAGE.Herein we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)methods.Both radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target binding.The source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains unexplained.We have also investigated use of lipopolysaccharide(LPS)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging agents.Immunoreactivity of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female groups.However,it proves challenging to quantify the changes in RAGE due to off-target binding of the radiotracers.Nevertheless,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNS penetration. | Lindsey R.Drake Allen F.Brooks Jenelle Stauff Phillip S.Sherman Janna Arteaga Robert A.Koeppe Aimee Reed Timothy J.Montavon Marc B.Skaddan Peter J.H.Scott | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 2 |
| 5 | Esophageal atresia and tracheoesophageal fistula:a review of current literature显示文摘 | Tamminga Janna S | 2006 | Pediatric Physical Therapy2006，18，1： | 1 |
| 6 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘 | Wang-Xia Wang Robert J. Danaher Craig S. Miller Joseph R. Berger Vega G. Nubia Bernard S. Wilfred Janna H. Neltner Christopher M. Norris Peter T. Nelson | 2013 | Genomics, Proteomics & Bioinformatics2013，，： | 1 |
| 7 | Homogeneous enzyme immunoassay for pyrethroid pesticides and their derivatives using bacillary alpha-amylase as label 显示文摘 | Boris B D Janna N T | 1997 | Analytica Chimica Acta1997，347，： | 1 |
| 8 | Synthesis, Properties and Dimerization Study of Isocyanic Acid 显示文摘 | Gerd F Janna G Thomas M K | 2002 | Z Naturforsch2002，57，1： | 1 |
| 9 | Alendronate in bone cement :fatigue life liegradeg by liquid,not by powder 显示文摘 | Lewis G Janna S | 2006 | Clin Orthop Relat Kes2006，445，： | 1 |
| 10 | Is synaptic loss a unique hallmark of Alzheimer’s disease?显示文摘 | Stephen W. Scheff Janna H. Neltner Peter T. Nelson | 2013 | Biochemical Pharmacology2013，，： | 1 |
| 11 | Pathophysiology of Macular Edema显示文摘 | Scholl Stefan Kirchhof Janna Augustin Albert J | 2010 | Ophthalmologica2010，，： | 1 |
| 12 | Does short-term heating of forest humus change its properties as a substrate for microbes显示文摘 | JANNA AUML I RISTO H | 2000 | Soil Biology and Biochemistry2000，32，2： | 1 |
| 13 | The Cys-loop pentameric ligand-gated ion channel receptors: 50 years on显示文摘 | JANNA L K ISABELLE M P | 2012 | Can J Physiol Pharmacol2012，90，6： | 1 |
| 14 | Numericalsimulationsofsingleandmultiple scatteringbyfractaliceclusters显示文摘 | Janna M.Dlugach MichaelI.Mishchenko DanielW.Mackowski | | 0，，11： | 1 |
| 15 | Old problems on a new playing field: Helminth zoonoses transmitted among dogs, wildlife, and people in a changing northern climate显示文摘 | Emily J. Jenkins Janna M. Schurer Karen M. Gesy | 2011 | Veterinary Parasitology2011，，1： | 1 |
| 16 | Homogeneous enzyme immunoassay for pyrethroid pesticides and their derivatives using bacillary alpha-amylase as label 显示文摘 | ANATOLIY V Z BORIS B D JANNA N T | 1997 | Analytica Chimica Acta1997，347，： | 1 |
| 17 | Esophagealatresia and tracheoesophagealfisyula:a review of currentliterature显示文摘 | Tamminga Janna S | 2006 | Pediatric Physical Therapy2006，18，1： | 1 |
| 18 | App与Web的未来显示文摘Web死了吗?不。专家们希望将Apps和Web汇聚成云;但许多人担心,实现用户的简便使用将需付出代价。 | Janna Quitney(著) Anderson Lee Rainie(著) 於维樱(编译) 宋菲(编译) | 2012 | 图书情报工作动态2012，，4： | 1 |
| 19 | From dishwasher to tap? xenobiotic substances benzotriazole and tolyltriazole in the en- vironment显示文摘 | Janna H Scrimshaw M D Williams R J | 2011 | Environ Sci Teehno12011，45，： | 1 |
| 20 | 环球看银幕显示文摘春天来了,奥斯卡到了,又是一个看电影的季节。让我们走进世界各地的影院,体验一下不同的感受。U.K.英国据说伦敦一个三五条街的soho区,就容纳了不下于30家各种各样的电影院。 | Janna | 2004 | 中国商界2004，，4： | 1 |
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