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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Pancreatic duct disruption and nonoperative management: the SEALANTS approach显示文摘Pancreatic-duct disruption (PDD) can be difficult to manage, with diverse etiologies and sequelae in a heterogeneous population. Common etiologies include pancreatitis, iatrogenic injury, and trauma. Sequelae of PDD include pseudocyst, pancreatic ascites, | Alain Abdo Niraj Jani Steven C Cunningham | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 2 |
| 3 | Post-growth treatment and contact formation on CVD diamond films for electronic application显示文摘 | JANY C FOULON F BERGONZO P MARSHALL R D | 1998 | Diamond and Related Materials1998，7，： | 1 |
| 4 | The prevalence and implications of ocular hypertension and glaucoma in thyroid-associated orbitopathy显示文摘 | Cockerham KP Pal C Jani B | | 0，，06： | 1 |
| 5 | Laparoscopic cholecystectomy in cirrhotic patients:the role of subtotal cholecystectomy and its variants显示文摘 | Palanivelu C Rajan PS Jani K | | 0，，： | 1 |
| 6 | Device-to-device communicationunder-laying cellular communications systems显示文摘 | JANIS P YU C DOPPLER K | 2009 | International JounalCommunications Network and System Sciences2009，2，3： | 1 |
| 7 | Synthesis of dipotassium dimethylsilanediolate monohydrate 显示文摘 | Stephen C Janis G M Michael J O | 2002 | Silicone Chemistry2002，，1： | 1 |
| 8 | Laparoscopic cholecystectomy in cirrhotic patients: The role of subtotal cholecystectomy and its variants 显示文摘 | Palanivelu C Rajan PS Jani K | 2006 | J Am Coll Surg2006，203，： | 1 |
| 9 | Urinary interleukin-18 is a marker of human acute tubular necrosis显示文摘 | Parikh C Jani A Melnikov VY | 2004 | Am J Kidney Dis2004，43，3： | 1 |
| 10 | Protective efficacy of recombinant modified vaccinia virus ankara delivering middle east respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-El- din H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 11 | Evidence of human papillomavirus in the placenta显示文摘 | Weyn C Thomas D Jani J | 2011 | J Infect Dis2011，203，3： | 1 |
| 12 | The first decade of Ecological Economics (Tenth anniversary survey articals) 显示文摘 | ROBERT C JANIS K | 1999 | Ecological Economics1999，，28： | 1 |
| 13 | Assessment of measles immunity among infants in Maputo City, Mozambique 显示文摘 | Jani JV Holm - Hansen C Mussa T | 2008 | BMC Public Health2008，8，1： | 1 |
| 14 | Laparoscopic pancreaticoduodenectomy: technique and outcomes 显示文摘 | Palanivelu C Jani K Senthilnathan P | 2007 | J Am Coll Surg2007，205，2： | 1 |
| 15 | Evidence of human papillomavirus in the placenta 显示文摘 | Weyn C Thomas D Jani J | 2011 | J Infect Dis2011，203，3： | 1 |
| 16 | Communi- cation and persuasion; psychological studies of opinion change显示文摘 | Hovland C I Janis I L Kelley H H | 1953 | 1953，，： | 1 |
| 17 | Evidence of human papillo-mavirrus in the placenta显示文摘 | Weyn C Thomas D Jani]y | 2011 | J Infect Dis2011，203，3： | 1 |
| 18 | Recurrent respiratory papillomatosis:an overview of current thinking and treatment显示文摘 | Goon P Sonnex C Jani P | 2008 | Eur Arch Otorhinolaryngol2008，265，2： | 1 |
| 19 | Laparoscopic management of benign nonparasitic hepatic cysts:A prospective nonrandomized stuay显示文摘 | Jani K Malladi V | 2006 | South Med J2006，99，10： | 1 |
| 20 | Laparoscopic distal pancreatectomy:results of a prospective non-randomized study from a tertiary center显示文摘 | Palanivelu C Shetty R Jani K | 2007 | Surg Endosc2007，21，3： | 1 |
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