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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 4 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 5 | Strengthening of reinforced concrete beams with externally bonded composite laminates显示文摘 | Jerome D M Tedesco J W | 1999 | ACI Structural Journal1999，96，2： | 1 |
| 6 | GPS Positioning in a Multipath Environment显示文摘 | Jerome S lnbar F Patrick D et aI | 2002 | IEEE Transactions on Signal Processing2002，50，1： | 1 |
| 7 | Moisture and strain rate effects on concrete strength 显示文摘 | Ross C A Jerome D M Tedesco J W | 1996 | ACI Materials Journal1996，93，3： | 1 |
| 8 | Moisture and strain rate effects on concrete strength显示文摘 | Ross C A Jerome D M Tedesco J W | 1996 | Materials Journal1996，93，3： | 1 |
| 9 | Comparison of free-breathing with navigator-controlled acquisition regimes in abdominal diffusion-weighted magnetic resonance images: effect on ADC and IVIM statistics显示文摘 | Jerome N P Orton M R D'Arcy J A | 2014 | J Magn Reson Imaging2014，39，1： | 1 |
| 10 | Microvascular obstruction assessed by 3 - tesla magnetic resonance imaging in acute myocardial infarction:correlation with plasma troponin I levels显示文摘 | Charles D Jerome I Nicolas M | 2010 | J Am Coll Cardiol2010，55，10： | 1 |
| 11 | Moisture and strain rate effects on concrete strength显示文摘 | Ross C A Jerome D M Tedesco J W | 1996 | ACI Material J1996，93，3： | 1 |
| 12 | Moisture and strain rate effects on concrete strength显示文摘 | Ross C A Jerome D M Tedesco J W | 1996 | ACI Material Journal1996，93，3： | 1 |
| 13 | A robust three phase power flow algorithm for radial distribution systems显示文摘 | Thukaram D Wijekoon Banda H M Jerome J | 1999 | Electric Power Systems Research1999，50，： | 1 |
| 14 | Influence of cooling temperature and duration on cold adaptation of Lactobacillus acidophilus RD 758显示文摘 | WANG Y JEROME D | 2005 | Cryobiology2005，50，3： | 1 |
| 15 | Moisture and strain rate effects on concrete strength显示文摘 | ROSS C A JEROME D M TEDESCO J W | 1996 | ACI Materials Journal1996，93，3： | 1 |
| 16 | Moisture and Strain Rate Effects on Concrete Strength显示文摘 | Ross C A Jerome D M | 1996 | ACI Mater J1996，93，3： | 1 |
| 17 | Moisture and strain rate effects on concrete strength显示文摘 | Ross C A Jerome D M Tedesco J W | 1996 | ACI Materials Journal1996，93，3： | 1 |
| 18 | Simulation of the dynamic response of concrete beams externally reinforced with carbon-fiber reinforced plastic 显示文摘 | Jerome D M Ross C A | 1997 | Computers & Structures1997，64，5： | 1 |
| 19 | Strengthening of reinforced concrete beam with externally bonded composite laminates 显示文摘 | ROSS C A JEROME D M TEDESCO J W | 1999 | ACI Structure Journal1999，96，2： | 1 |
| 20 | Ischemic preconditioning attenuates capillary no-reflow induced by ischemia and reperfusion显示文摘 | Jerome S Akimitsu T Gute D | 1995 | Am J Physiol1995，268，5： | 1 |
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