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| 1 | Metabolically based liver damage pathophysiology in patients with urea cycle disorders-A new hypothesis显示文摘The underlying pathophysiology of liver dysfunction in urea cycle disorders(UCDs) is still largely elusive. There is some evidence that the accumulation of urea cycle(UC) intermediates are toxic for hepatocyte mitochondria. It is possible that liver injury is directly caused by the toxicity of ammonia. The rarity of UCDs, the lack of checking of iron level in these patients, superficial knowledge of UC and an underestimation of the metabolic role of fumaric acid, are the main reasons that are responsible for the incomprehension of the mechanism of liver injury in patients suffering from UCDs. Owing to our routine clinical practice to screen for iron overload in severely ill neonates, with the focus on the newborns suffering from acute liver failure, we report a case of citrullinemia with neonatal liver failure and high blood parameters of iron overload. We hypothesize that the key is in the decreased-deficient fumaric acid production in the course of UC in UCDs that causes several sequentially intertwined metabolic disturbances with final result of liver iron overload. The presented hypothesis could be easily tested by examining the patients suffering from UCDs, for liver iron overload. This could be easily performed in countries with a high population and comprehensive national register for inborn errors of metabolism. Conclusion: Providing the hypothesis is correct, neonatal liver damage in patients having UCD can be prevented by the supplementation of pregnant women with fumaric or succinic acid, prepared in the form of iron supplementation pills. After birth, liverdamage in patients having UCDs can be prevented by supplementation of these patients with zinc fumarate or zinc succinylate, as well. | Ivan Ivanovski Milos Jesic Ana Ivanovski Livia Garavelli Petar Ivanovski | 2017 | World Journal of Gastroenterology2017，23，44： | 4 |
| 2 | Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis显示文摘AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy. | Tamara Alempijevic Miodrag Krstic Rada Jesic Ivan Jovanovic Aleksandra Sokic Milutinovic Nada Kovacevic Slobodan Krstic Dragan Popovic | 2009 | World Journal of Gastroenterology2009，15，5： | 4 |
| 3 | Right liver lobe/albumin ratio:Contribution to non-invasive assessment of portal hypertension显示文摘瞄准:学习价值生物化学并且在存在的预言和食道的静脉曲张的尺寸的 ultraso-nographic 参数。方法:学习包括经历了一个完全的生物化学的工作在上面的选择肝脏硬化症的病人,上面内视镜的 digestive 和 ultrasonographic 考试。白朊 / 权利肝脑叶直径和血小板计数 / 脾直径比率是计算的。在食道的静脉曲张的计算比率和存在和度之间的关联被评估。结果:94 个题目(62 男性, 32 女性) ,与 52.32 +/- 的吝啬的年龄 13.60 年,被学习。孩子呸班 A 占了 42.6% ,班 B 37.2% ,而班 C 20.2% 。,食道的静脉曲张(OE ) 没被上面的消化内视镜检查法在 24.5% 表明我在 22.3% 病人,被发现的 OE 等级在 33.0% 分级 II,在 16.0% 分级 III,并且分级在 4.3% 的 IV。正确的肝脑叶直径 / 白朊比率的吝啬的价值是 5.51 +/- 1.82 (从 2.76 ~ 11.44 的范围) 当吝啬的血小板计数 / 脾直径比率是 1017.75 +/- 时 729.36 (从 117.39 ~ 3362.50 的范围) 分别地。统计上重要的关联被枪兵在 OE 等级和计算比率之间的测试证明。P 价值是 0.481 并且 -0.686, 分别地。结论:正确的肝脑叶直径 / 白朊和血小板计数 / 脾直径比率是提供对食道的静脉曲张,并且他们与肝肝硬化在病人分级的存在的决心恰当的精确信息的非侵略的参数。 | Tamara Alempijevic Vladislava Bulat Srdjan Djuranovic Nada Kovacevic Rada Jesic Dragan Tomic Slobodan Krstic Miodrag Krstic | 2007 | World Journal of Gastroenterology2007，13，40： | 4 |
| 4 | Parapha- ryngeal space tumors: 61 case reviews 显示文摘 | Dimitrijevic M V Jesic S D Mikie A A | 2010 | Int J Oral Maxillofac Surg2010，39，10： | 1 |
| 5 | Influence of acetylsalicylic acid (asprin)on biofilm production by Candida species显示文摘 | Stepanovic S Vukovic D Jesic M | 2004 | J Chenother2004，16，： | 1 |
| 6 | Enzymatic study of tonsil tissue alkaline and acid phosphatase in children with recurrent tonsillitis and tonsil hypertrophy 显示文摘 | Jesic S Stojiljkovic L Stosic S | 2010 | International journal of pediatric otorhinolaryngology2010，74，1： | 1 |
| 7 | Epithelial- myoepithelial carcinoma--review of clinicopathological and immu- nohistochemical features显示文摘 | Dimitrijevic M V Tomanovic N R Jesic S D | 2015 | Arch Iran Med2015，18，4： | 1 |
| 8 | MR imaging of primary sclerosing cholangitis: additional value of diffusion- weighted imaging and ADC measurement 显示文摘 | Djokic Kovac J Jesic R Stanisavljevic D | 2013 | Acta Radiol2013，54，： | 1 |
| 9 | Temporalis fascia graft perforation and retraction after tympanoplasty for chronic tubotympanic otitis and attic retraction pockets:factors associated with recurrence显示文摘 | JESIC S D DIMITRIJEVIC M V NESIC V S | 2011 | Arch Otolaryngol Head Neck Surg2011，137，： | 1 |
| 10 | Influence of acetylsalicylic acid (aspirin) on biofilm production by Candida species 显示文摘 | Stepanovic S Vukovic D Jesic M | 2004 | J Chemother2004，16，2： | 1 |
| 11 | Temporalis fascia graft perforation and retraction after tympanoplasty for chronic tubotympanic otitis and attic retraction pockets:factors associated with recurrence显示文摘 | JESIC S D DIMITRIJEVIC M V NESIC V S | 2011 | Arch Otolaryngol Head Neck Surg2011，137，： | 1 |
| 12 | Parapharyngeal space tumors: 61 case reviews显示文摘 | Dimitrijeric MV Jesic SD Mikic AA | 2010 | Int J Oral Maxillofac Surg2010，39，10： | 1 |
| 13 | Parapharyngeal space tumors: 61 case reviews显示文摘 | Dimitrijevic M V Jesic S D Mikic A A | 2010 | Int J Oral Maxillofac Surg2010，39，10： | 1 |
| 14 | Sepsis as a cause of intrahepatic cholestasis显示文摘 | Rudic J Jesic R Culafic D | 2009 | Srp Arh Celok Lek2009，137，56： | 1 |
| 15 | Parapharyngeal space tumors: 61 case reviews 显示文摘 | Dimitrijevic M V Jesic S D Mikic A A | 2010 | Int J Oral Maxillefac Surg2010，39，10： | 1 |
| 16 | Parapharyngeal space tumors: 61 case reviews显示文摘 | Dimitrijevic MV Jesic SD Mikic AA | 2010 | Int J Oral Maxillofac Surg2010，39，10： | 1 |
| 17 | Parapharyn- geal space tumors: 61 case reviews 显示文摘 | Dimitrijevic MV Jesic SD Mikic AA | 2010 | Int J Oral Maxil- lofac Surg2010，39，10： | 1 |
| 18 | Electrolardiography and echocardiography in the diagnosis of chronic cor pulmonale显示文摘 | Putnik M Povazan D Vindis Jesic M | 1998 | Med Preg11998，51，1112： | 1 |
| 19 | Common Fixed Point Theorems in Intuitionistic Fuzzy Metric Spaces and Fuzzy Metric Spaces with Nonlinear Contractive Condition显示文摘 | JESIC S N BABACEV N A | | 0，，： | 1 |
| 20 | Paradoxical em- boli-clinical importance of transcranial Doppler for detection of patent foramen ovale 显示文摘 | Zivanovic Z Ruzicka-Kaloci S Jesic A | 2010 | Med Pregl2010，63，78： | 1 |
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