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| 1 | Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid显示文摘AIM: To investigate Time- and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively. METHODS: DS tablets and 5-ASA pellets were coated by ethylcellulose (EC) and methacrylic acid copolymers (Eudragit L100 and $100), respectively. The in vitro release behavior of the DS coated tablets and 5-ASA coated pellets were examined, and then in vivo absorption kinetics of DS coated tablets in dogs were further studied. RESULTS: Release profile of time-dependent DS coated tablets was not influenced by pH of the dissolution medium, but the lag time of DS release was primarily controlled by the thickness of the coating layer. The thicker the coating layer, the longer the lag time of DS release is. On the contrary, in view of the pH-dependent 5-ASA coated pellets, 5-ASA release was significantly governed by pH. Moreover, the 5-ASA release features from the coated pellets depended upon both the combination ratio of the Eudragit~ L100 and S100 pH-sensitive copolymers in the coating formulation and the thickness of the coating layer. The absorption kinetic studies of the DS coated tablets in dogs demonstrated that in vivo lag time of absorption was in a good agreement with in vitro lag time of release. CONCLUSION: Two types of CDDS, prepared herein by means of the regular coating technique, are able to achieve site-specific drug delivery targeting at colon following oral administration, and provide a promising strategy to control drug release targeting the desired lower gastrointestinal region. | GangCheng FengAn Mei-JuanZou JinSun Xiu-HuaHao Yun-XiaHe | 2004 | World Journal of Gastroenterology2004，10，12： | 6 |
| 2 | Atmospheric corrosion of two field-exposed AZ31B magnesium alloys with different grain size显示文摘 | Jinsun Liao Makoto Hotta Shin-ichi Motoda Tadashi Shinohara | 2013 | Corrosion Science2013，，： | 1 |
| 3 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary(BBIA)approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 4 | Mining Botnets and Their Evolution Patterns显示文摘The botnet is the network of compromised computers that have fallen under the control of hackers after being infected by malicious programs such as trojan viruses. The compromised machines are mobilized to perform various attacks including mass spamming, distributed denial of service (DDoS) and additional trojans. This is becoming one of the most serious threats to the Internet infrastructure at present. We introduce a method to uncover compromised machines and characterize their behaviors using large email logs. We report various spam campaign variants with different characteristics and introduce a statistical method to combine them. We also report the long-term evolution patterns of the spam campaigns. | Jaehoon Choi Jaewoo Kang Jinseung Lee Chihwan Song Qingsong Jin Sunwon Lee Jinsun Uh | 2013 | Journal of Computer Science & Technology2013，28，4： | 1 |
| 5 | Charac teristics and corrosion resistance of plasma electrolytic oxi dation coatings on AZ31B Mg alloy formed in phosphateSilicate mixture electrolytes 显示文摘 | Yoichi Mori Akihiko KOshi Jinsun Liao | 2014 | Corrosion Science2014，88，： | 1 |
| 6 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 7 | Nitride precipitation in weld HAZ of a duplex stainless steel显示文摘 | Jinsun Liao | 2001 | ISIJ international2001，41，5： | 1 |
| 8 | The Role of Vimentin as a Methylation Biomarker for Early Diagnosis of Cervical Cancer 显示文摘 | Samil Jung Lisha Yi Jinsun Kim | 2011 | Mol Cells2011，31，5： | 1 |
| 9 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 10 | Microstructural modification and mechanical property improvement in friction stir zone of thixo-molded AE42 Mg alloy 显示文摘 | LINA YU KAZUHIRO NAKATA JINSUN LIAO | 2009 | Journal of Alloys and Compounds2009，480，2： | 1 |
| 11 | Propagation and attenuation characteristics of various ground vibrations 显示文摘 | Kim Dongsoo Lee Jinsun | 2000 | Soil Dynamics and Earthquake Engineering2000，，2： | 1 |
| 12 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 13 | Activation of autophagy during glutamate-induced HT22 cell death 显示文摘 | Hansoo K Jinsun C Joohyun R | 2009 | Biochem Biophys Res Commun2009，388，2： | 1 |
| 14 | Total endoscopic thyroid- ectomy with bilaleral breast areola and ipsilateral axillary(BBIA) ap- proach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 15 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，： | 1 |
| 16 | Total endoscopic thyroidectomy with bilateral bmast areola and ipsilateral axillary(BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 17 | Studies on the thermal cycling reliability of BGA system in package with an embedded die显示文摘 | SEON Y Y YONG M K JINSUN K | 2012 | IEEE Trans Compon Packg Manuf Technol2012，2，4： | 1 |
| 18 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach 显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 19 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary (BBIA) approach显示文摘 | Jeryong K Jinsun L Hyegyong K | 2008 | World J Surg2008，32，11： | 1 |
| 20 | Total endoscopic thyroidectomy with bilateral breast areola and ipsilateral axillary(BBIA) approach显示文摘 | JERYONG K JINSUN L HYEGYONG K | | 0，，11： | 1 |
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