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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | 澳大利亚全科医学近几十年的变化显示文摘全科医学一直是澳大利亚医疗体系的基石,几乎所有的澳大利亚人每年至少看1次全科医生。本文试图概述1990—2015年澳大利亚全科医生队伍、全科医生接诊的患者以及患者疾病的复杂性所发生的主要变化,发现在过去的25年里,全科医生群体、接诊的患者情况和就诊内容均发生了变化,全科医生的临床工作重点更倾向于老年人保健、慢性病管理、临床和治疗程序、转诊和检查。 | Helena Britt Graeme C Miller Lisa Valenti Joan Henderson Clare Bayram Julie Gordon 本刊编辑部 | 2016 | 中国全科医学2016，19，33： | 3 |
| 4 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 5 | Childhood obesity显示文摘 | Joan C Han Debbie A Lawlor Sue YS Kimm | 2010 | The Lancet2010，，9727： | 2 |
| 6 | Detailed debris flow hazard assessment in Andorm: A multidisciplinary approach显示文摘 | H Mareel C Ramon A Joan | 2006 | Geomorphology2006，78，34： | 1 |
| 7 | Morphological Classes as Natural Categories 显示文摘 | Bybee Joan &Moder C | 1983 | Language1983，，59： | 1 |
| 8 | Microbical contamination of stored hydrocarbon fuels and its control显示文摘 | CHRISTINE C G FATIMA M B JOAN K | 2003 | Journal of Microbiology2003，32，4： | 1 |
| 9 | A novel interferon regulatory factor (IRF),IRF-10,has a unique role in immune defense and is induced by the v-Rel oncoprotein显示文摘 | Ji(r)í Nehyba Radmila Hrdli(c)ková Joan Burnside | 2002 | Molecular and Cellular Biology2002，22，： | 1 |
| 10 | Preparation of the yeast Pichia pastoris for transmission electron microscopy 显示文摘 | Benjamin A Y Joan L C Geoff P L C | 2006 | Microscopy Today2006，14，5： | 1 |
| 11 | The relation- ship between structural empowerment and psy chological empowerment review 显示文摘 | Joan I W Greta C Donnal S | 2010 | Journal of for nurses: A systematic Nursing Management2010，18，4： | 1 |
| 12 | Inactivation of Lactobacillus bevies in orange juice by high- intensity pulsed electric fields 显示文摘 | Pedro Elez- Martinez Joan Escola- Hernandez Robert C Soliva-Fortuny | 2005 | Food Microbiology2005，22，： | 1 |
| 13 | Measuring the performance of electronic government services 显示文摘 | Joan C Steyaert | 2004 | Information & Management2004，，3： | 1 |
| 14 | On User-defined Features显示文摘 | Hoffmann C M Joan Arroyo R | 1998 | Computer-Aided Design1998，30，5： | 1 |
| 15 | Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum显示文摘 | Juhong Liu Sasha Akoulitchev Achim Weber Hui Ge Sergei Chuikov Daniel Libutti Xin W Wang Joan Weliky Conaway Curtis C Harris Ronald C Conaway Danny Reinberg David Levens | 2001 | Cell2001，，3： | 1 |
| 16 | Heterologous protein expression in the methylotrophic yeast Pichia pastoris显示文摘 | JOAN L C JAMES M C | 2000 | FEMS Microbiology Reviews2000，24，： | 1 |
| 17 | Evidence-based systematic review:Effects of oral motor interventions on feeding and swallowing in preterm infants显示文摘 | Joan A Healther C Cathy L | 2010 | American Journal of Speech-Language Pathology2010，19，： | 1 |
| 18 | Effects of phenolic compounds in bluebe-rries and muscadine grapes on HepG2 cell viability and apoptosis显示文摘 | Weiguang Yia Casimir C Akoh Joan Fischer | 2006 | Food Research International2006，39，： | 1 |
| 19 | Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments显示文摘 | Inês O. Gon?alves Emanuel Passos Silvia Rocha-Rodrigues Cátia V. Diogo Joan R. Torrella David Rizo Ginés Viscor Estela Santos-Alves Inês Marques-Aleixo Paulo J. Oliveira António Ascens?o José Magalh?es | 2014 | Mitochondrion2014，，： | 1 |
| 20 | Correction of the anemia of end-stage renal disease with ricombinant human erythropoietin: Results of a combined phase I and II clinical trial显示文摘 | Eschbach MD Joan C | 1987 | New Eng J of Med1987，8，： | 1 |
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